Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: Reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism

Toxicological Sciences

Volumn 108, Issue 2, 2009, Pages 482-491

  Lecureux, Lloyd ^a   Dieter, Matthew Z ^b,c   Nelson, David M ^a,d   Watson, Linda ^a   Wong, Harvey ^a,e   Gemzik, Brian ^a   Klaassen, Curtis D ^b   Lehman McKeeman, Lois D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c ABBOTT LABORATORIES   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e GENENTECH INC   (United States)

Author keywords

Biliary excretion; Hepatic transporters; Mrp2; Thyroxine; TR rat

Indexed keywords

CYTOCHROME P450; GLUCURONOSYLTRANSFERASE; LIOTHYRONINE; MULTIDRUG RESISTANCE PROTEIN 2; PEPTIDE TRANSPORTER 1; PHENOBARBITAL; PHTHALIC ACID DIMETHYL ESTER; THYROID HORMONE; THYROTROPIN; THYROXINE; THYROXINE I 125; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; GLUCURONIDATION; HOMEOSTASIS; HYPOTHYROIDISM; LIVER LEVEL; MALE; NONHUMAN; PLASMA CLEARANCE; RAT; THYROXINE BLOOD LEVEL; WISTAR RAT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BILIARY TRACT; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; HOMEOSTASIS; HYPOTHYROIDISM; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; RECEPTORS, THYROID HORMONE; RNA, MESSENGER; THYROID GLAND; THYROID HORMONES; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE; XENOBIOTICS;

RATTUS;

EID: 64349106089     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp026     Document Type: Article

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