Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction

Toxicology and Applied Pharmacology

Volumn 180, Issue 1, 2002, Pages 56-63

  Johnson, David R ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

3 methylcholanthrene; Benxo(a)pyrene; Biliary excretion; Dibromosulfophthalein; EHBR; Mrp2; Phenobarbital; Pregnenolone 16 carbonitrile

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 3 METHYLCHOLANTHRENE; BENZO[A]PYRENE; CARRIER PROTEIN; DIBROMOSULFOPHTHALEIN; MICROSOME ENZYME; MULTIDRUG RESISTANCE PROTEIN 2; PHENOBARBITAL;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; ENZYME INDUCTION; HYPERBILIRUBINEMIA; MALE; NONHUMAN; PLASMA; PROTEIN INDUCTION; RAT;

EID: 0036535488     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9375     Document Type: Article

References (27)

1. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
2. Role of glutathione and hepatic glutathione S-transferase in the biliary excretion of methyl mercury, cadmium and zinc: A study with enzyme inducers and glutathione depletors
3. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
4. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
5. Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia
6. Preserved organic anion transport in mutant TR - Rats with a hepatobiliary secretion defect
7. Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls (SH) in rats by drug-metabolizing enzyme inducers is mediated by Multidrug resistance protein 2 (Mrp2)
8. Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats
9. Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction
10. Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance
11. Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia
12. Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
13. Effect of P-450 inducers on biliary excretion of glutathione and its hydrolysis products: Correlation between hepatic gamma-glutamyltranspeptidase activity and the proportion of glutathione hydrolysis products in bile
14. Expression and localization of multidrug resistant protein mrp2 in rat small intestine
15. Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophthalein in the isolated perfused rat liver
16. Characterization of inducible nature of MRP3 in rat liver
17. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte
18. The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics
19. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
20. Differential effects on microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2
21. ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins
22. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats
23. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
24. 4, and ethanol on the biliary efflux of glutathione in rats
25. Inhibition of steroid 5 alpha-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450
26. Uptake of organic anions by isolated rat hepatocytes: A classification in terms of ATP-dependency
27. Effect of spironolactone, pregnenolone-16α-carbonitrile and cortisol on the metabolism and biliary excretion of sulfobromophthalein and phenol-3,6-dibromophthalein disulfonate in rats