Marked enhancement of antigen-specific T-cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant

European Journal of Immunology

Volumn 40, Issue 2, 2010, Pages 351-358

  Nam, Hyo Jung ^a   Song, Mi Young ^a   Choi, Dong Hoon ^a   Yang, Se Hwan ^a   Jin, Hyun Tak ^a   Sung, Young Chul ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

IL 7; Lytic and nonlytic Fc fusion; T cell responses; Vaccination

Indexed keywords

FC RECEPTOR; HYBRID PROTEIN; HYDROLASE; INTERLEUKIN 7; OVALBUMIN; RECOMBINANT PROTEIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; DNA IMMUNIZATION; FEMALE; GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; VACCINATION; WART VIRUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-7; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; ONCOGENE PROTEINS, VIRAL; OVALBUMIN; T-LYMPHOCYTES; VACCINATION; VACCINES, DNA;

EID: 75149194434     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939271     Document Type: Article

References (35)

1. Boyman, O., Purton, J. F., Surh, C. D. and Sprent, J., Cytokines and T-cell homeostasis. Curr. Opin. Immunol. 2007. 19: 320-326.
2. Lee, S. K. and Surh, C. D., Role of interleukin-7 in bone and T-cell homeostasis. Immunol. Rev. 2005. 208: 169-180.
3. Alves, N. L., Arosa, F. A. and van Lier, R. A., Common gamma chain cytokines: dissidence in the details. Immunol. Lett. 2007. 108: 113-120.
4. Ma, A., Koka, R. and Burkett, P., Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 2006. 24: 657-679.
5. Melchionda, F., Fry, T. J., Milliron, M. J., McKirdy, M. A., Tagaya, Y. and Mackall, C. L., Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool. J. Clin. Invest. 2005. 115: 1177-1187.
6. Nanjappa, S. G.,Walent, J. H., Morre, M. and Suresh, M., Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice. J. Clin. Invest. 2008. 118: 1027-1039.
7. Boyman, O., Ramsey, C., Kim,D.M., Sprent, J. and Surh, C.D., IL-7/Anti-IL-7 mAb Complexes Restore T Cell Development and Induce Homeostatic T Cell Expansion without Lymphopenia. J. Immunol. 2008. 180: 7265-7275.
8. Sin, J. I., Kim, J., Pachuk, C. and Weiner, D. B., Interleukin 7 can enhance antigen-specific cytotoxic-T-lymphocyte and/or Th2-type immune responses in vivo. Clin. Diagn. Lab. Immunol. 2000. 7: 751-758.
9. Calarota, S. A., Dai, A., Trocio, J. N., Weiner, D. B., Lori, F. and Lisziewicz, J., IL-15 as memory T-cell adjuvant for topical HIV-1 DermaVir vaccine. Vaccine 2008. 26: 5188-5195.
10. Zagury, D., Burny, A. and Gallo, R. C., Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines. Proc. Natl. Acad. Sci. USA 2001. 98: 8024-8029.
11. Morell, A., Terry, W. D. and Waldmann, T. A., Metabolic properties of IgG subclasses in man. J. Clin. Invest. 1970. 49: 673-680.
12. Ramalingam, T. S., Detmer, S. A., Martin, W. L. and Bjorkman, P. J., IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution. EMBO J. 2002. 21: 590-601.
13. Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J. andWard, E. S., Increasing the serum persistence of an IgG fragment by random mutagenesis. Nat. Biotechnol. 1997. 15: 637-640.
14. Zheng, X. X., Steele, A. W., Nickerson, P. W., Steurer, W., Steiger, J. and Strom, T. B., Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J. Immunol. 1995. 154: 5590-5600.
15. Zheng, X. X., Steele, A. W., Hancock, W. W., Kawamoto, K., Li, X. C., Nickerson, P.W., Li, Y. et al., IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. J. Immunol. 1999. 163: 4041-4048.
16. Siberil, S., Dutertre, C. A., Fridman, W. H. and Teillaud, J. L., FcgammaR: The key to optimize therapeutic antibodies? Crit. Rev.Oncol. Hematol. 2007. 62: 26-33.
17. Ravetch, J. V. and Bolland, S., IgG Fc receptors. Annu. Rev. Immunol. 2001. 19: 275-290.
18. Nimmerjahn, F. and Ravetch, J. V., Fcgamma receptors as regulators of immune responses. Nat. Rev. Immunol. 2008. 8: 34-47.
19. McLain, L. and Dimmock, N. J., A monoclonal antibody produced during infection which recognizes an epitope of influenza hemagglutinin only in the context of H-2k MHC class I antigen. J. Immunol. 1993. 150: 3421-3426.
20. Idusogie, E. E., Wong, P. Y., Presta, L. G., Gazzano-Santoro, H., Totpal, K., Ultsch, M. and Mulkerrin, M. G., Engineered antibodies with increased activity to recruit complement. J. Immunol. 2001. 166: 2571-2575.
21. Appasamy, P. M., Biological and clinical implications of interleukin-7 and lymphopoiesis. Cytokines Cell Mol. Ther. 1999. 5: 25-39.
22. Vivier, E., Tomasello, E., Baratin, M., Walzer, T. and Ugolini, S., Functions of natural killer cells. Nat. Immunol. 2008. 9: 503-510.
23. Biswas, S. K., Sica, A. and Lewis, C. E., Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J. Immunol. 2008. 180: 2011-2017.
24. Boyman, O., Kovar, M., Rubinstein, M. P., Surh, C. D. and Sprent, J., Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006. 311: 1924-1927.
25. Kamimura, D., Sawa, Y., Sato, M., Agung, E., Hirano, T. and Murakami, M., IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 2006. 177: 306-314.
26. Phelan, J. D., Orekov, T. and Finkelman, F. D., Cutting edge: mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodies. J. Immunol. 2008. 180: 44-48.
27. Pabbisetty, K. B., Yue, X., Li, C., Himanen, J. P., Zhou, R., Nikolov, D. B. and Hu, L., Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay. Protein Sci. 2007. 16: 355-361.
28. Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi,M., Yoshida, H. and Nishikawa, S., Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA 1993. 90: 9125-9129.
29. Kutzler, M. A., Robinson, T. M., Chattergoon, M. A., Choo, D. K., Choo, A. Y., Choe, P. Y., Ramanathan, M. P. et al., Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J. Immunol. 2005. 175: 112-123.
30. Stoklasek, T. A., Schluns, K. S. and Lefrancois, L., Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J. Immunol. 2006. 177: 6072-6080.
31. Dubois, S., Mariner, J., Waldmann, T. A. and Tagaya, Y., IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 2002. 17: 537-547.
32. Kim, D. J., Youn, J. I., Seo, S. H., Jin, H. T. and Sung, Y. C., Differential regulation of antigen-specific CD8+ T cell responses by IL-12p40 in a dose-dependent manner. J. Immunol. 2008. 180: 7167-7174.
33. Ha, S. J., Jeon, B. Y., Kim, S. C., Kim, D. J., Song, M. K., Sung, Y. C. and Cho, S. N., Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosis. Gene Ther. 2003. 10: 1592-1599.
34. Jin, H. T., Youn, J. I., Kim, H. J., Lee, J. B., Ha, S. J., Koh, J. S. and Sung, Y. C., Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor. Hum. Gene Ther. 2005. 16: 328-338.
35. Jin, H. T., Youn, J. I., Choi, S. Y., Seo, S. H., Park, S. H., Song, M. Y., Yang, S. H. and Sung, Y. C., Adenovirus-mediated gene transfer of interleukin-23 shows prophylactic but not therapeutic antitumor effects. Cancer Gene Ther. 2008. 15: 693-702.