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Volumn 16, Issue 3, 2005, Pages 328-338

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; LB 42908; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P40; UNCLASSIFIED DRUG;

EID: 16344371747     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2005.16.328     Document Type: Article
Times cited : (22)

References (53)
  • 1
    • 12944254575 scopus 로고    scopus 로고
    • DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • AMICI, A., SMORLESI, A., NOCE, G., SANTONI, G., CAPPELLETTI, P., CAPPARUCCIA, L., COPPARI, R., LUCCIARINI, R., PETRELLI, C., and PROVINCIALI, M. (2000). DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Gene Ther. 7, 703-706.
    • (2000) Gene Ther. , vol.7 , pp. 703-706
    • Amici, A.1    Smorlesi, A.2    Noce, G.3    Santoni, G.4    Cappelletti, P.5    Capparuccia, L.6    Coppari, R.7    Lucciarini, R.8    Petrelli, C.9    Provinciali, M.10
  • 2
    • 0032535052 scopus 로고    scopus 로고
    • Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor
    • ARMITAGE, J.O. (1998). Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. Blood 92, 4491-4508.
    • (1998) Blood , vol.92 , pp. 4491-4508
    • Armitage, J.O.1
  • 3
    • 0023930413 scopus 로고
    • Effect of low dose cyclophosphamide on the immune system of cancer patients: Depletion of CD4+, 2H4+ suppressor-inducer T-cells
    • BERD, D., and MASTRANGELO, M.J. (1988). Effect of low dose cyclophosphamide on the immune system of cancer patients: depletion of CD4+, 2H4+ suppressor-inducer T-cells. Cancer Res. 48, 1671-1675.
    • (1988) Cancer Res. , vol.48 , pp. 1671-1675
    • Berd, D.1    Mastrangelo, M.J.2
  • 4
    • 0031178963 scopus 로고    scopus 로고
    • Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer
    • CHEN, L., CHEN, D., BLOCK, E., O'DONNELL, M., KUFE, D.W., and CLINTON, S.K. (1997). Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J. Immunol. 159, 351-359.
    • (1997) J. Immunol. , vol.159 , pp. 351-359
    • Chen, L.1    Chen, D.2    Block, E.3    O'Donnell, M.4    Kufe, D.W.5    Clinton, S.K.6
  • 6
    • 0000081175 scopus 로고
    • Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases
    • CLARKE, S., VOGEL, J.P., DESCHENES, R.J., and STOCK, J. (1988). Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 85, 4643-4647.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 4643-4647
    • Clarke, S.1    Vogel, J.P.2    Deschenes, R.J.3    Stock, J.4
  • 7
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • COLOMBO, M.P., and TRINCHIERI, G. (2002). Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13, 155-168.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 8
    • 0036467445 scopus 로고    scopus 로고
    • Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
    • COOPER, A.M., KIPNIS, A., TURNER, J., MAGRAM, J., FERRANTE, J., and ORME, I.M. (2002). Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J. Immunol. 168, 1322-1327.
    • (2002) J. Immunol. , vol.168 , pp. 1322-1327
    • Cooper, A.M.1    Kipnis, A.2    Turner, J.3    Magram, J.4    Ferrante, J.5    Orme, I.M.6
  • 9
    • 0036667388 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Promises and realities
    • COX, A.D., and DER, C.J. (2002). Farnesyltransferase inhibitors: promises and realities. Curr. Opin. Pharmacol. 2, 388-393.
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 388-393
    • Cox, A.D.1    Der, C.J.2
  • 10
    • 0029834981 scopus 로고    scopus 로고
    • Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles
    • D'ANDREA, A., CHANG, C., PHILLIPS, J.H., and LANIER, L.L. (1996). Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184, 789-794.
    • (1996) J. Exp. Med. , vol.184 , pp. 789-794
    • D'Andrea, A.1    Chang, C.2    Phillips, J.H.3    Lanier, L.L.4
  • 11
    • 0034665093 scopus 로고    scopus 로고
    • The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement
    • DI CARLO, E., COMES, A., BASSO, S., DE AMBROSIS, A., MEAZZA, R., MUSIANI, P., MOELLING, K., ALBINI, A., and FERRINI, S. (2000). The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement. J. Immunol. 165, 3111-3118.
    • (2000) J. Immunol. , vol.165 , pp. 3111-3118
    • Di Carlo, E.1    Comes, A.2    Basso, S.3    De Ambrosis, A.4    Meazza, R.5    Musiani, P.6    Moelling, K.7    Albini, A.8    Ferrini, S.9
  • 12
    • 0020000608 scopus 로고
    • Selective effects of Adriamycin on murine host defense systems
    • EHRKE, M.J., COHEN, S.A., and MIHICH, E. (1982). Selective effects of Adriamycin on murine host defense systems. Immunol. Rev. 65, 55-78.
    • (1982) Immunol. Rev. , vol.65 , pp. 55-78
    • Ehrke, M.J.1    Cohen, S.A.2    Mihich, E.3
  • 13
    • 0036891867 scopus 로고    scopus 로고
    • Antagonistic effect of NK cells on alternatively activated monocytes: A contribution of NK cells to CTL generation
    • GELDHOF, A.B., VAN GINDERACHTER, J.A., LIU, Y., NOEL, W., RAES, G., and DE BAETSELIER, P. (2002). Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation. Blood 100, 4049-4058.
    • (2002) Blood , vol.100 , pp. 4049-4058
    • Geldhof, A.B.1    Van Ginderachter, J.A.2    Liu, Y.3    Noel, W.4    Raes, G.5    De Baetselier, P.6
  • 15
    • 0000155803 scopus 로고    scopus 로고
    • A novel function of IL-12p40 as a chemotactic molecule for macrophages
    • HA, S.J., LEE, C.H., LEE, S.B., KIM, C.M., JANG, K.L., SHIN, H.S., and SUNG, Y.C. (1999). A novel function of IL-12p40 as a chemotactic molecule for macrophages. J. Immunol. 163, 2902-2908.
    • (1999) J. Immunol. , vol.163 , pp. 2902-2908
    • Ha, S.J.1    Lee, C.H.2    Lee, S.B.3    Kim, C.M.4    Jang, K.L.5    Shin, H.S.6    Sung, Y.C.7
  • 17
    • 0018886371 scopus 로고
    • Importance of timing in cyclophosphamide therapy of MOPC-315 tumor-bearing mice
    • HENGST, J.C., MOKYR, M.B., and DRAY, S. (1980). Importance of timing in cyclophosphamide therapy of MOPC-315 tumor-bearing mice. Cancer Res. 40, 2135-2141.
    • (1980) Cancer Res. , vol.40 , pp. 2135-2141
    • Hengst, J.C.1    Mokyr, M.B.2    Dray, S.3
  • 19
    • 0025006629 scopus 로고
    • Suppressor cell activity in a randomized trial of patients receiving active specific immunotherapy with melanoma cell vaccine and low dosages of cyclophosphamide
    • HOON, D.S., FOSHAG, L.J., NIZZE, A.S., BOHMAN, R., and MORTON, D.L. (1990). Suppressor cell activity in a randomized trial of patients receiving active specific immunotherapy with melanoma cell vaccine and low dosages of cyclophosphamide. Cancer Res. 50, 5358-5364.
    • (1990) Cancer Res. , vol.50 , pp. 5358-5364
    • Hoon, D.S.1    Foshag, L.J.2    Nizze, A.S.3    Bohman, R.4    Morton, D.L.5
  • 20
    • 0032760925 scopus 로고    scopus 로고
    • IL-2 plasmid therapy of murine ovarian carcinoma inhibits the growth of tumor ascites and alters its cytokine profile
    • HORTON, H.M., DORIGO, O., HERNANDEZ, P., ANDERSON, D., BEREK, J.S., and PARKER, S.E. (1999). IL-2 plasmid therapy of murine ovarian carcinoma inhibits the growth of tumor ascites and alters its cytokine profile. J. Immunol. 163, 6378-6385.
    • (1999) J. Immunol. , vol.163 , pp. 6378-6385
    • Horton, H.M.1    Dorigo, O.2    Hernandez, P.3    Anderson, D.4    Berek, J.S.5    Parker, S.E.6
  • 23
    • 0027494385 scopus 로고
    • Action of natural killer cells and macrophages in cancer
    • KLEIN, E., and MANTOVANI, A. (1993). Action of natural killer cells and macrophages in cancer. Curr. Opin. Immunol. 5, 714-718.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 714-718
    • Klein, E.1    Mantovani, A.2
  • 25
    • 0031664801 scopus 로고    scopus 로고
    • Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene
    • LEE, S.W., CHO, J.H., and SUNG, Y.C. (1998). Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene. J. Virol. 72, 8430-8436.
    • (1998) J. Virol. , vol.72 , pp. 8430-8436
    • Lee, S.W.1    Cho, J.H.2    Sung, Y.C.3
  • 26
    • 0344197021 scopus 로고    scopus 로고
    • IL-6 induces long-term protective immunity against a lethal challenge of influenza virus
    • LEE, S.W., YOUN, J.W., SEONG, B.L., and SUNG, Y.C. (1999). IL-6 induces long-term protective immunity against a lethal challenge of influenza virus. Vaccine 17, 490-496.
    • (1999) Vaccine , vol.17 , pp. 490-496
    • Lee, S.W.1    Youn, J.W.2    Seong, B.L.3    Sung, Y.C.4
  • 28
    • 0037449518 scopus 로고    scopus 로고
    • Comparison of the antitumor efficacies of Her-2/neu DNA vaccines inducing contrasting IgG immunity but comparable CTL activity in mice
    • LEE, J.Y., KIM, D.H., CHUNG, Y., SHIN, S.U., and KANG, C.Y. (2003). Comparison of the antitumor efficacies of Her-2/neu DNA vaccines inducing contrasting IgG immunity but comparable CTL activity in mice. Vaccine 21, 521-531.
    • (2003) Vaccine , vol.21 , pp. 521-531
    • Lee, J.Y.1    Kim, D.H.2    Chung, Y.3    Shin, S.U.4    Kang, C.Y.5
  • 29
    • 0035500298 scopus 로고    scopus 로고
    • IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis
    • LEHMANN, J., BELLMANN, S., WERNER, C., SCHRODER, R., SCHUTZE, N., and ALBER, G. (2001). IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J. Immunol. 167, 5304-5315.
    • (2001) J. Immunol. , vol.167 , pp. 5304-5315
    • Lehmann, J.1    Bellmann, S.2    Werner, C.3    Schroder, R.4    Schutze, N.5    Alber, G.6
  • 30
    • 0032521211 scopus 로고    scopus 로고
    • Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
    • MANGUES, R., CORRAL, T., KOHL, N.E., SYMMANS, W.F., LU, S., MALUMBRES, M., GIBBS, J.B., OLIFF, A., and PELLICER, A. (1998). Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res. 58, 1253-1259.
    • (1998) Cancer Res. , vol.58 , pp. 1253-1259
    • Mangues, R.1    Corral, T.2    Kohl, N.E.3    Symmans, W.F.4    Lu, S.5    Malumbres, M.6    Gibbs, J.B.7    Oliff, A.8    Pellicer, A.9
  • 31
    • 0030938148 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta production by interleukin-12
    • MARTH, T., STROBER, W., SEDER, R.A., and KELSALL, B.L. (1997). Regulation of transforming growth factor-beta production by interleukin-12. Eur. J. Immunol. 27, 1213-1220.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1213-1220
    • Marth, T.1    Strober, W.2    Seder, R.A.3    Kelsall, B.L.4
  • 32
    • 0027200981 scopus 로고
    • The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
    • MATTNER, F., FISCHER, S., GUCKES, S., JIN, S., KAULEN, H., SCHMITT, E., RUDE, E., and GERMANN, T. (1993). The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23, 2202-2208.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2202-2208
    • Mattner, F.1    Fischer, S.2    Guckes, S.3    Jin, S.4    Kaulen, H.5    Schmitt, E.6    Rude, E.7    Germann, T.8
  • 33
    • 0031764881 scopus 로고    scopus 로고
    • Interleukin-12 and its free p40 subunit regulate immune recognition of endometrial cells: Potential role in endometriosis
    • MAZZEO, D., VIGANO, P., DI BLASIO, A.M., SINIGAGLIA, F., VIGNALI, M., and PANINA-BORDIGNON, P. (1998). Interleukin-12 and its free p40 subunit regulate immune recognition of endometrial cells: Potential role in endometriosis. J. Clin. Endocrinol. Metab. 83, 911-916.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 911-916
    • Mazzeo, D.1    Vigano, P.2    Di Blasio, A.M.3    Sinigaglia, F.4    Vignali, M.5    Panina-Bordignon, P.6
  • 34
    • 0242360790 scopus 로고    scopus 로고
    • Combinations of anticancer drugs and immunotherapy
    • MITCHELL, M.S. (2003). Combinations of anticancer drugs and immunotherapy. Cancer Immunol. Immunother. 52, 686-692.
    • (2003) Cancer Immunol. Immunother. , vol.52 , pp. 686-692
    • Mitchell, M.S.1
  • 35
    • 0036453256 scopus 로고    scopus 로고
    • Adjuvant immunotherapy for solid tumors: From promise to clinical application
    • MOCELLIN, S., ROSSI, C.R., LISE, M., and MARINCOLA, F.M. (2002). Adjuvant immunotherapy for solid tumors: From promise to clinical application. Cancer Immunol. Immunother. 51, 583-595.
    • (2002) Cancer Immunol. Immunother. , vol.51 , pp. 583-595
    • Mocellin, S.1    Rossi, C.R.2    Lise, M.3    Marincola, F.M.4
  • 36
    • 0028908324 scopus 로고
    • Paracrine cytokine adjuvants in cancer immunotherapy
    • PARDOLL, D.M. (1995). Paracrine cytokine adjuvants in cancer immunotherapy. Annu. Rev. Immunol. 13, 399-415.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 399-415
    • Pardoll, D.M.1
  • 38
    • 0029947820 scopus 로고    scopus 로고
    • Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors
    • RAKHMILEVICH, A.L., TURNER, J., FORD, M.J., MCCABE, D., SUN, W.H., SONDEL, P.M., GROTA, K., and YANG, N.S. (1996). Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc. Natl. Acad. Sci. U.S.A. 93, 6291-6296.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6291-6296
    • Rakhmilevich, A.L.1    Turner, J.2    Ford, M.J.3    Mccabe, D.4    Sun, W.H.5    Sondel, P.M.6    Grota, K.7    Yang, N.S.8
  • 39
    • 0025194466 scopus 로고
    • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides
    • REISS, Y., GOLDSTEIN, J.L., SEABRA, M.C., CASEY, P.J., and BROWN, M.S. (1990). Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell 62, 81-88.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 42
    • 0033540621 scopus 로고    scopus 로고
    • Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA
    • SCHULTZ, J., PAVLOVIC, J., STRACK, B., NAWRATH, M., and MOELLING, K. (1999). Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA. Hum. Gene Ther. 10, 407-417.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 407-417
    • Schultz, J.1    Pavlovic, J.2    Strack, B.3    Nawrath, M.4    Moelling, K.5
  • 43
    • 0030955210 scopus 로고    scopus 로고
    • Antitumor activities of IL-12 and mechanisms of action
    • SHURIN, M.R., ESCHE, C., PERON, J.M., and LOTZE, M.T. (1997). Antitumor activities of IL-12 and mechanisms of action. Chem. Immunol. 68, 153-174.
    • (1997) Chem. Immunol. , vol.68 , pp. 153-174
    • Shurin, M.R.1    Esche, C.2    Peron, J.M.3    Lotze, M.T.4
  • 44
    • 0032101974 scopus 로고    scopus 로고
    • T cell-and NK cell-independent inhibition of hepatic metastases by systemic administration of an IL-12-expressing recombinant adenovirus
    • SIDERS, W.M., WRIGHT, P.W., HIXON, J.A., ALVORD, W.G., BACK, T.C., WILTROUT, R.H., and FENTON, R.G. (1998). T cell-and NK cell-independent inhibition of hepatic metastases by systemic administration of an IL-12-expressing recombinant adenovirus. J. Immunol. 160, 5465-5474.
    • (1998) J. Immunol. , vol.160 , pp. 5465-5474
    • Siders, W.M.1    Wright, P.W.2    Hixon, J.A.3    Alvord, W.G.4    Back, T.C.5    Wiltrout, R.H.6    Fenton, R.G.7
  • 45
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • SMYTH, M.J., GODFREY, D.I., and TRAPANI, J.A. (2001). A fresh look at tumor immunosurveillance and immunotherapy. Nat. Immunol. 2, 293-299.
    • (2001) Nat. Immunol. , vol.2 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 46
    • 0031603125 scopus 로고    scopus 로고
    • Superiority of interleukin-12-transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice
    • SUMIMOTO, H., TANI, K., NAKAZAKI, Y., TANABE, T., HIBINO, H., WU, M.S., IZAWA, K., HAMADA, H., and ASANO, S. (1998). Superiority of interleukin-12- transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice. Cancer Gene Ther. 5, 29-37.
    • (1998) Cancer Gene Ther. , vol.5 , pp. 29-37
    • Sumimoto, H.1    Tani, K.2    Nakazaki, Y.3    Tanabe, T.4    Hibino, H.5    Wu, M.S.6    Izawa, K.7    Hamada, H.8    Asano, S.9
  • 47
    • 0027953555 scopus 로고
    • Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
    • TAHARA, H., ZEH, H.J., 3RD, STORKUS, W.J., PAPPO, I., WATKINS, S.C., GUBLER, U., WOLF, S.F., ROBBINS, P.D., and LOTZE, M.T. (1994). Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res. 54, 182-189.
    • (1994) Cancer Res. , vol.54 , pp. 182-189
    • Tahara, H.1    Zeh III, H.J.2    Storkus, W.J.3    Pappo, I.4    Watkins, S.C.5    Gubler, U.6    Wolf, S.F.7    Robbins, P.D.8    Lotze, M.T.9
  • 48
    • 0032528446 scopus 로고    scopus 로고
    • The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
    • TANNENBAUM, C.S., TUBBS, R., ARMSTRONG, D., FINKE, J.H., BUKOWSKI, R.M., and HAMILTON, T.A. (1998). The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. J. Immunol. 161, 927-932.
    • (1998) J. Immunol. , vol.161 , pp. 927-932
    • Tannenbaum, C.S.1    Tubbs, R.2    Armstrong, D.3    Finke, J.H.4    Bukowski, R.M.5    Hamilton, T.A.6
  • 49
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • TRINCHIERI, G. (1998). Interleukin-12: A cytokine at the interface of inflammation and immunity. Adv. Immunol. 70, 83-243.
    • (1998) Adv. Immunol. , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 50
    • 0036789525 scopus 로고    scopus 로고
    • Adenovirus-mediated combined P16 gene and GM-CSF gene therapy for the treatment of established tumor and induction of antitumor immunity
    • WANG, L., QI, X., SUN, Y., LIANG, L., and JU, D. (2002). Adenovirus-mediated combined P16 gene and GM-CSF gene therapy for the treatment of established tumor and induction of antitumor immunity. Cancer Gene Ther. 9, 819-824.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 819-824
    • Wang, L.1    Qi, X.2    Sun, Y.3    Liang, L.4    Ju, D.5
  • 53
    • 0029148905 scopus 로고
    • Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
    • ZITVOGEL, L., TAHARA, H., ROBBINS, P.D., STORKUS, W.J., CLARKE, M.R., NALESNIK, M.A., and LOTZE, M.T. (1995). Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J. Immunol. 155, 1393-1403.
    • (1995) J. Immunol. , vol.155 , pp. 1393-1403
    • Zitvogel, L.1    Tahara, H.2    Robbins, P.D.3    Storkus, W.J.4    Clarke, M.R.5    Nalesnik, M.A.6    Lotze, M.T.7


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