Megaloblastosis: From morphos to molecules

Medical Principles and Practice

Volumn 14, Issue SUPPL. 1, 2005, Pages 2-14

  Das, K C ^a   Das, Monisha ^b   Mohanty, D ^b   Jadaon, M M ^a   Gupta, A ^a   Marouf, R ^a   Easow, S K ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

^b NATIONAL INSTITUTE OF IMMUNOHAEMATOLOGY   (India)

Author keywords

3H thymidine incorporation; Autoradiography; Chromosomal despiralization; Deoxyuridine suppression test; DNA synthesis; Electron microscopy; Histone biosynthesis; Megaloblastosis

Indexed keywords

ARGININE; CELL DNA; CYANOCOBALAMIN; DEOXYURIDINE; FOLIC ACID; HISTONE; LYSINE; PROTEINASE K; SYNTHETIC DNA; THYMIDINE; THYMIDINE PHOSPHATE; TRYPTOPHAN;

ANEMIA; BIOSYNTHESIS; BONE MARROW; BONE MARROW CELL; CELL STRUCTURE; CHROMATIN; CHROMOSOME; CONFERENCE PAPER; CYANOCOBALAMIN DEFICIENCY; DISEASE COURSE; DNA SYNTHESIS; ERYTHROLEUKEMIA; EXTRACTION; FOLIC ACID DEFICIENCY; HUMAN; MEGALOBLASTIC ANEMIA; MYELODYSPLASTIC SYNDROME; NONHUMAN; RHESUS MONKEY; TRANSMISSION ELECTRON MICROSCOPY;

ADOLESCENT; ADULT; ANEMIA, MEGALOBLASTIC; ANIMALS; CASE-CONTROL STUDIES; CHILD; CYTOGENETIC ANALYSIS; DNA; FEMALE; FOLIC ACID DEFICIENCY; GENETIC MARKERS; HISTONE CODE; HISTONES; HUMANS; MACACA MULATTA; MALE; MEGALOBLASTS; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, WISTAR; SUPPRESSION, GENETIC; VITAMIN B 12 DEFICIENCY;

EID: 23844551773     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086179     Document Type: Conference Paper

References (40)

1. Chanarin I: The Megaloblastic Anaemia, ed 3. Oxford, Blackwell Scientific Publications, 1990, pp 315-331.
2. Wills L: Treatment of pernicious anaemia of pregnancy and 'tropical anaemia' with special reference to yeast extract as a curative agent. Br Med J 1931;1:1059-1064.
3. Wills L: Treatment of pernicious anaemia, nutritional macrocytic anaemia and tropical sprue. Blood 1948;3:36-56.
4. Chatterjea JB: Nutritional megaloblastic anaemia in tropical zones. Proc 11th Congr Int Soc Hematol, Sidney, 1966, pp 120-132.
5. Das KC: Nutritional megaloblastic anaemia. Proc Symp Nutr Anemias, Plenary Sess 2, Meet Asian Pacific Div, Int Soc Hematol, Melbourne, 1971, pp 11-13.
6. Herbert V: The five possible causes of all nutrient deficiency. Aust NZ J Med 1972;1:69-72.
7. 12-folate interrelations. Clin Haematol 1976;5:997-725.
8. Herbert V: The Megaloblastic Anemias, ed 1. New York, Grune and Stratton, 1959, p 1.
9. Lee RG: Megaloblastic anemias: Disorders of impaired DNA synthesis; in Lee RG, Foester J, Lukens J, Parakevas JP, Rodgers GM (eds): Wintrobe's Clinical Hematology, ed 10. Baltimore, Williams & Wilkins, 1999, pp 941-978.
10. Das KC, Hoffbrand AV: Lymphocyte transformation in megaloblastic anaemias. Morphology and DNA synthesis. Br J Haematol 1970;19:459-468.
11. 12. Br J Haematol 1978;38:219-223.
12. 12-deficient humans. Br J Haematol 1968;14:575-592.
13. Mohanty D, Das KC: Effect of folate deficiency on the reproductive organs of female Rhesus monkeys: A cytomorphological and cytokinetic study. J Nutr 1982;112:1505-1576.
14. Johnson EM, Nelson MM, Monie IN: The composition of folate-deficient diet for rats. Anat Rec 1963;146:215.
15. Dacie JV, Lewis SM: Practical Haematology, ed 8. London, Churchill Livingstone, 1995, pp 49-143.
16. Das KC, Herbert V: In vitro DNA synthesis by megaloblastic bone marrow: Effect of folates and cobalamins on thymidine incorporation and de novo thymidylate synthesis. Am J Hematol 1989;31:11-20.
17. 3H-deoxyuridine into DNA: Enhancement of incorporation when inadequate vitamin 812 and folate is corrected. Br J Haematol 1980;44:51-63.
18. Das KC, Garewal G, Mohanty D: Derangement of DNA synthesis in erythroleukemia. Normal deoxyuridine suppression and impaired thymidine incorporation in bone marrow culture. Acta Haematol 1980;64:121-134.
19. Das KC, Mohanty D, Garewal G: Cytogenetics in nutritional megaloblastic anaemia: Prolonged persistence of chromosomal abnormalities in lymphocytes after remission. Acta Haematol 1986;76:146-154.
20. Sambrook J, Fritsch EF, Maniatis J: Molecular Cloning: A Laboratory Manual. New York, Cold Spring Harbor Laboratory Press, 1989, pp 1-25.
21. Murray K: The acid extraction of histones from calf thymus deoxyribonucleoprotein. J Mol Biol 1966;15:409-419.
22. Das KC, Kaufman RP, Gay H: Autoradiographic evidence of synthesis of an arginine-rich histone during spermatogenesis in Drosophila melanogaster. Nature 1964;204:1008-1009.
23. Tidwell T, Allfrey VF, Mirsky AE: The methylation of histone during regeneration of the liver. J Biol Chem 1968;243:707-715.
24. Gershey FL, Halett GW, Vidali G, Allfrey VG: Chemical studies on histone methylation. Evidence for the occurrence of 3-methyl-histidine in avian erythrocyte histone fraction. J Biol Chem 1969;244:4871-4877.
25. Longo DL, Herbert V: Radioassay for serum and red cell folate. J Lab Clin Med 1976;87:138-151.
26. 12 (cobalamin) in serum and erythrocytes by radioassay and of holo-transcobalamin II (holo-TC-II) and holo-haptocorrin (holo-TC1 and III) in serum by adsorbing holo-TC-II on microfine silica. J Nutr Biochem 1991;2:455-463.
27. Kiossoglou, KA, Mitus WJ, Dameshek W: Chromosomal aberrations in pernicious anemia. Study of three cases before and after therapy. Blood 1965;5:662-682.
28. 12 and folate deficiency. Blood 1966;27:800-815.
29. Das KC: Nutritional megaloblastosis. Symp Nutr Anaemias. Proc Second Congr Asian Pacific Div, Int Soc Haematol, New Delhi, 1976, pp 14-15.
30. Hoffbrand AV, Pegg AE: Base composition of normal and megaloblastic bone marrow DNA. Nat New Biol 1972;235:187-188.
31. Khobta A, Carlo-Stella C, Capranico G: Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. Cancer Res 2004;64:2656-2662.
32. Zhao J: Coordination of DNA synthesis and histone gene expression during normal cell cycle progression and after DNA damage. Cell Cycle 2004;3:695-697.
33. Norbury CJ, Zhivolovsky B: DNA damage-induced apoptosis. Oncogene 2004;23:2797-2808.
34. Wang C, Fu M, Pestell RG: Histone acetylation/deacetylation as a regulator of cell cycle gene expression. Methods Mol Biol 2004;241:207-216.
35. McLaughlin F, La Thangue NB: Histone deacetylase inhibitors open new doors in cancer therapy. Biochem Pharmacol 2004;68:1139-1144.
36. Ingram CF, Davidoff AN, Marais F, Sherman GG, Mendelow BV: Evaluation of DNA analysis for evidence of apoptosis in megaloblastic anaemia. Br J Haematol 1997;96:576-583.
37. Koury MJ, Price JO, Hicks GG: Apoptosis in megaloblastic anemia occurs during DNA synthesis p53-independent, nucleoside-reversible mechanism. Blood 2000;96:3249-3255.
38. Gu L, Wu J, Qiu L, Jennings CD, Li GM: Involvement of DNA mismatch repair infolate deficiency-induced apoptosis small star, filled. J Nutr Biochem 2002;13:355-363.
39. Li GM, Presnell SR, Gu I: Folate deficiency, mismatch repair-independent apoptosis and human disease. J Nutr Biochem 2003;14:568-575.
40. Das KC, Easow SK, Jadaon M, Das M, Mohanty D: The development of megaloblastosis is a species-restricted phenomenon. 9th Annu Health Sci Poster Conf, Kuwait, April 19-21, 2004, p 284.