메뉴 건너뛰기




Volumn 40, Issue 2, 2010, Pages 417-425

Apoptotic lymphocytes treated with IgG from Trypanosoma cruzi infection increase TNF-α secretion and reduce parasite replication in macrophages

Author keywords

Ab; Apoptosis; Fc receptors; Phagocytosis; Trypanosoma cruzi

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

EID: 75149118315     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939606     Document Type: Article
Times cited : (9)

References (47)
  • 1
    • 0019050269 scopus 로고
    • Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer
    • Kierszenbaum, F., Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer. J. Parasitol. 1980. 66: 673-675.
    • (1980) J. Parasitol , vol.66 , pp. 673-675
    • Kierszenbaum, F.1
  • 2
    • 0023759597 scopus 로고
    • Characterization of antibody isotype responsible for immune clearance in mice infected with Trypanosoma cruzi
    • Brodskyn, C. I., da Silva, A. M., Takehara, H. A. and Mota, I., Characterization of antibody isotype responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunol. Lett. 1988. 18: 255-258.
    • (1988) Immunol. Lett , vol.18 , pp. 255-258
    • Brodskyn, C.I.1    da Silva, A.M.2    Takehara, H.A.3    Mota, I.4
  • 3
    • 0025598341 scopus 로고
    • Monoclonal antibodies mediating viable immunofluorescence and protection against Trypanosoma cruzi infection
    • Heath, A. W., Martins, M. S. and Hudson, L., Monoclonal antibodies mediating viable immunofluorescence and protection against Trypanosoma cruzi infection. Trop. Med. Parasitol. 1990. 41: 425-428.
    • (1990) Trop. Med. Parasitol , vol.41 , pp. 425-428
    • Heath, A.W.1    Martins, M.S.2    Hudson, L.3
  • 4
    • 0031859154 scopus 로고    scopus 로고
    • The relative contribution of antibody production and CD8+T cell function to immune control of Trypanosoma cruzi
    • Kumar, S. and Tarleton, R. L., The relative contribution of antibody production and CD8+T cell function to immune control of Trypanosoma cruzi. Parasite Immunol. 1998. 20: 207-216.
    • (1998) Parasite Immunol , vol.20 , pp. 207-216
    • Kumar, S.1    Tarleton, R.L.2
  • 6
    • 0024854756 scopus 로고
    • Immunobiology of murine T cruzi infection: The predominance of parasite-nonspecific responses and the activation of TCRI T cells
    • Minoprio, P., Itohara, S., Heusser, C., Tonegawa, S. and Coutinho, A., Immunobiology of murine T cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells. Immunol. Rev. 1989. 112: 183-207.
    • (1989) Immunol. Rev , vol.112 , pp. 183-207
    • Minoprio, P.1    Itohara, S.2    Heusser, C.3    Tonegawa, S.4    Coutinho, A.5
  • 7
    • 55349121536 scopus 로고    scopus 로고
    • Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in mice
    • Lu, B., Alroy, J., Luquetti, A. O. and PereiraPerrin, M., Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in mice. Am. J. Pathol. 2008. 173: 1406-1414.
    • (2008) Am. J. Pathol , vol.173 , pp. 1406-1414
    • Lu, B.1    Alroy, J.2    Luquetti, A.O.3    PereiraPerrin, M.4
  • 8
    • 0028816515 scopus 로고
    • Activation-induced CD4+T cell death by apoptosis in experimental Chagas' disease
    • Lopes, M. F., da Veiga, V. F., Santos, A. R., Fonseca, M. E. and DosReis, G. A., Activation-induced CD4+T cell death by apoptosis in experimental Chagas' disease. J. Immunol. 1995. 154: 744-752.
    • (1995) J. Immunol , vol.154 , pp. 744-752
    • Lopes, M.F.1    da Veiga, V.F.2    Santos, A.R.3    Fonseca, M.E.4    DosReis, G.A.5
  • 9
    • 0032791044 scopus 로고    scopus 로고
    • Gamma interferon modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide-induced apoptosis during the acute phase of Trypanosoma cruzi infection: A possible role in immune response control
    • Martins, G. A., Vieira, L. Q., Cunha, F. Q. and Silva, J. S., Gamma interferon modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide-induced apoptosis during the acute phase of Trypanosoma cruzi infection: a possible role in immune response control. Infect. Immun. 1999. 67: 3864-3871.
    • (1999) Infect. Immun , vol.67 , pp. 3864-3871
    • Martins, G.A.1    Vieira, L.Q.2    Cunha, F.Q.3    Silva, J.S.4
  • 10
    • 0037090160 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection selectively renders parasite-specific IgG+B lymphocytes susceptible to Fas/Fas ligand-mediated fratricide
    • Zuniga, E., Motran, C. C., Montes, C. L., Yagita, H. and Gruppi, A., Trypanosoma cruzi infection selectively renders parasite-specific IgG+B lymphocytes susceptible to Fas/Fas ligand-mediated fratricide. J. Immunol. 2002. 168: 3965-3973.
    • (2002) J. Immunol , vol.168 , pp. 3965-3973
    • Zuniga, E.1    Motran, C.C.2    Montes, C.L.3    Yagita, H.4    Gruppi, A.5
  • 12
    • 38349054015 scopus 로고    scopus 로고
    • Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi
    • De Meis, J., Ferreira, L. M., Guillermo, L. V., Silva, E. M., DosReis, G. A. and Lopes, M. F., Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi. Eur. J. Immunol. 2008. 38: 139-146.
    • (2008) Eur. J. Immunol , vol.38 , pp. 139-146
    • De Meis, J.1    Ferreira, L.M.2    Guillermo, L.V.3    Silva, E.M.4    DosReis, G.A.5    Lopes, M.F.6
  • 14
    • 0041461862 scopus 로고    scopus 로고
    • Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi
    • Ariyanayagam, M. R., Oza, S. L., Mehlert, A. and Fairlamb, A. H., Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi. J. Biol. Chem. 2003. 278: 27612-27619.
    • (2003) J. Biol. Chem , vol.278 , pp. 27612-27619
    • Ariyanayagam, M.R.1    Oza, S.L.2    Mehlert, A.3    Fairlamb, A.H.4
  • 15
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y. and Henson, P. M., Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 1998. 101: 890-898.
    • (1998) J. Clin. Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 16
    • 16844377358 scopus 로고    scopus 로고
    • The role of IgM antibodies in the recognition and clearance of apoptotic cells
    • Peng, Y., Kowalewski, R., Kim, S. and Elkon, K. B., The role of IgM antibodies in the recognition and clearance of apoptotic cells. Mol. Immunol. 2005. 42: 781-787.
    • (2005) Mol. Immunol , vol.42 , pp. 781-787
    • Peng, Y.1    Kowalewski, R.2    Kim, S.3    Elkon, K.B.4
  • 17
    • 0034528139 scopus 로고    scopus 로고
    • Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha)
    • Moosig, F., Csernok, E., Kumanovics, G. and Gross, W. L., Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). Clin. Exp. Immunol. 2000. 122: 499-503.
    • (2000) Clin. Exp. Immunol , vol.122 , pp. 499-503
    • Moosig, F.1    Csernok, E.2    Kumanovics, G.3    Gross, W.L.4
  • 18
    • 0031825552 scopus 로고    scopus 로고
    • Systemic exposure to irradiated apoptotic cells induces autoantibody production
    • Mevorach, D., Zhou, J. L., Song, X. and Elkon, K. B., Systemic exposure to irradiated apoptotic cells induces autoantibody production. J. Exp. Med. 1998. 188: 387-392.
    • (1998) J. Exp. Med , vol.188 , pp. 387-392
    • Mevorach, D.1    Zhou, J.L.2    Song, X.3    Elkon, K.B.4
  • 20
    • 0033224252 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey
    • Marguet, D., Luciani, M. F., Moynault, A., Williamson, P. and Chimini, G., Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey. Nat. Cell Biol. 1999. 1: 454-456.
    • (1999) Nat. Cell Biol , vol.1 , pp. 454-456
    • Marguet, D.1    Luciani, M.F.2    Moynault, A.3    Williamson, P.4    Chimini, G.5
  • 21
    • 0042941922 scopus 로고    scopus 로고
    • Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells
    • Canetti, C., Hu, B., Curtis, J. L. and Peters-Golden, M., Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells. Blood 2003. 102: 1877-1883.
    • (2003) Blood , vol.102 , pp. 1877-1883
    • Canetti, C.1    Hu, B.2    Curtis, J.L.3    Peters-Golden, M.4
  • 22
    • 0025157238 scopus 로고
    • Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions Functional activation of Fc gamma RII by treatment with proteases or neuraminidase
    • Debets, J. M., Van de Winkel, J. G., Ceuppens, J. L., Dieteren, I. E. and Buurman, W. A., Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions Functional activation of Fc gamma RII by treatment with proteases or neuraminidase. J. Immunol. 1990. 144: 1304-1310.
    • (1990) J. Immunol , vol.144 , pp. 1304-1310
    • Debets, J.M.1    Van de Winkel, J.G.2    Ceuppens, J.L.3    Dieteren, I.E.4    Buurman, W.A.5
  • 23
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    • Huynh, M. L., Fadok, V. A. and Henson, P. M., Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 2002. 109: 41-50.
    • (2002) J. Clin. Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 24
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen, L. A., Anhalt, G. and Rosen, A., Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 1994. 179: 1317-1330.
    • (1994) J. Exp. Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 25
    • 0035113791 scopus 로고    scopus 로고
    • Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens
    • Gensler, T. J., Hottelet, M., Zhang, C., Schlossman, S., Anderson, P. and Utz, P. J., Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens. J. Autoimmun. 2001. 16: 59-69.
    • (2001) J. Autoimmun , vol.16 , pp. 59-69
    • Gensler, T.J.1    Hottelet, M.2    Zhang, C.3    Schlossman, S.4    Anderson, P.5    Utz, P.J.6
  • 26
    • 2442707797 scopus 로고    scopus 로고
    • Nucleosomes are exposed at the cell surface in apoptosis
    • Radic, M., Marion, T. and Monestier, M., Nucleosomes are exposed at the cell surface in apoptosis. J. Immunol. 2004. 172: 6692-6700.
    • (2004) J. Immunol , vol.172 , pp. 6692-6700
    • Radic, M.1    Marion, T.2    Monestier, M.3
  • 29
    • 0031663762 scopus 로고    scopus 로고
    • Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera
    • Bach-Elias, M., Bahia, D., Teixeira, D. C. and Cicarelli, R. M., Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera. Parasitol. Res. 1998. 84: 796-799.
    • (1998) Parasitol. Res , vol.84 , pp. 796-799
    • Bach-Elias, M.1    Bahia, D.2    Teixeira, D.C.3    Cicarelli, R.M.4
  • 30
    • 0032416392 scopus 로고    scopus 로고
    • Complement-dependent clearance of apoptotic cells by human macrophages
    • Mevorach, D., Mascarenhas, J. O., Gershov, D. and Elkon, K. B., Complement-dependent clearance of apoptotic cells by human macrophages. J. Exp. Med. 1998. 188: 2313-2320.
    • (1998) J. Exp. Med , vol.188 , pp. 2313-2320
    • Mevorach, D.1    Mascarenhas, J.O.2    Gershov, D.3    Elkon, K.B.4
  • 31
    • 70449710443 scopus 로고    scopus 로고
    • IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
    • Chen, Y., Park, Y. B., Patel, E. and Silverman, G. J., IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J. Immunol. 2009. 182: 6031-6043.
    • (2009) J. Immunol , vol.182 , pp. 6031-6043
    • Chen, Y.1    Park, Y.B.2    Patel, E.3    Silverman, G.J.4
  • 33
    • 0037122009 scopus 로고    scopus 로고
    • Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7
    • Verbovetski, I., Bychkov, H., Trahtemberg, U., Shapira, I., Hareuveni, M., Ben-Tal, O., Kutikov, I. et al., Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. J. Exp. Med. 2002. 196: 1553-1561.
    • (2002) J. Exp. Med , vol.196 , pp. 1553-1561
    • Verbovetski, I.1    Bychkov, H.2    Trahtemberg, U.3    Shapira, I.4    Hareuveni, M.5    Ben-Tal, O.6    Kutikov, I.7
  • 34
    • 0037438495 scopus 로고    scopus 로고
    • Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: Dependence on complement receptors and effect on cytokine production
    • Morelli, A. E., Larregina, A. T., Shufesky, W. J., Zahorchak, A. F., Logar, A. J., Papworth, G. D., Wang, Z. et al., Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 2003. 101: 611-620.
    • (2003) Blood , vol.101 , pp. 611-620
    • Morelli, A.E.1    Larregina, A.T.2    Shufesky, W.J.3    Zahorchak, A.F.4    Logar, A.J.5    Papworth, G.D.6    Wang, Z.7
  • 35
    • 23444461619 scopus 로고    scopus 로고
    • Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: A novel pathogenic pathway for autoimmunity ?
    • Frisoni, L., McPhie, L., Colonna, L., Sriram, U., Monestier, M., Gallucci, S. and Caricchio, R., Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity ? J. Immunol. 2005. 175: 2692-2701.
    • (2005) J. Immunol , vol.175 , pp. 2692-2701
    • Frisoni, L.1    McPhie, L.2    Colonna, L.3    Sriram, U.4    Monestier, M.5    Gallucci, S.6    Caricchio, R.7
  • 36
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boulé, M. W., Broughton, C., Mackay, F., Akira, S., Marshak-Rothstein, A. and Rifkin, I. R., Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 2004. 199: 1631-1640.
    • (2004) J. Exp. Med , vol.199 , pp. 1631-1640
    • Boulé, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 37
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means, T. K., Latz, E., Hayashi, F., Murali, M. R., Golenbock, D. T. and Luster, A. D., Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 2005. 115: 407-417.
    • (2005) J. Clin. Invest , vol.115 , pp. 407-417
    • Means, T.K.1    Latz, E.2    Hayashi, F.3    Murali, M.R.4    Golenbock, D.T.5    Luster, A.D.6
  • 39
    • 34147115539 scopus 로고    scopus 로고
    • Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection
    • Silva, E. M., Guillermo, L. V., Ribeiro-Gomes, F. L., De Meis, J., Nunes, M. P., Senra, J. F., Soares, M. B. et al., Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection. Eur. J. Immunol. 2007. 37: 738-746.
    • (2007) Eur. J. Immunol , vol.37 , pp. 738-746
    • Silva, E.M.1    Guillermo, L.V.2    Ribeiro-Gomes, F.L.3    De Meis, J.4    Nunes, M.P.5    Senra, J.F.6    Soares, M.B.7
  • 41
    • 0028913239 scopus 로고    scopus 로고
    • Lopes, M. F., Cunha, J. M. T., Bezerra, F. L., Gonzalez, M. S., Gomes, J. E. L., Lapa e Silva, J. R., Garcia, E. S. and DosReis, G. A., Trypanosoma cruzi: Both chemically induced and triatomine derived metacyclic trypomastigotes cause the same immunological disturbances in the infected mammalian host. Exp. Parasitol. 1995. 80: 194-204.
    • Lopes, M. F., Cunha, J. M. T., Bezerra, F. L., Gonzalez, M. S., Gomes, J. E. L., Lapa e Silva, J. R., Garcia, E. S. and DosReis, G. A., Trypanosoma cruzi: Both chemically induced and triatomine derived metacyclic trypomastigotes cause the same immunological disturbances in the infected mammalian host. Exp. Parasitol. 1995. 80: 194-204.
  • 42
    • 0025848913 scopus 로고
    • Hyperthermia induces apoptosis in thymocytes
    • Sellins, K. S. and Cohen, J. J., Hyperthermia induces apoptosis in thymocytes. Radiat. Res. 1991. 126: 88-95.
    • (1991) Radiat. Res , vol.126 , pp. 88-95
    • Sellins, K.S.1    Cohen, J.J.2
  • 43
    • 0031939406 scopus 로고    scopus 로고
    • Activationinduced T cell death exacerbates Trypanosoma cruzi replication in macrophages cocultured with CD4+T lymphocytes from infected hosts
    • Nunes, M. P., Andrade, R. M., Lopes, M. F. and DosReis, G. A., Activationinduced T cell death exacerbates Trypanosoma cruzi replication in macrophages cocultured with CD4+T lymphocytes from infected hosts. J. Immunol. 1998. 160: 1313-1319.
    • (1998) J. Immunol , vol.160 , pp. 1313-1319
    • Nunes, M.P.1    Andrade, R.M.2    Lopes, M.F.3    DosReis, G.A.4
  • 45
    • 0034687696 scopus 로고    scopus 로고
    • Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses
    • Shi, Y., Zheng, W. and Rock, K. L., Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc. Natl. Acad. Sci. USA 2000. 97: 14590-14595.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14590-14595
    • Shi, Y.1    Zheng, W.2    Rock, K.L.3
  • 46
    • 0028133043 scopus 로고
    • Global analysis of antibody repertoires I An immunoblot method for the quantitative screening of a large number of reactivities
    • Haury, M., Grandien, A., Sundblad, A., Coutinho, A. and Nobrega, A., Global analysis of antibody repertoires I An immunoblot method for the quantitative screening of a large number of reactivities. Scand. J. Immunol. 1994. 39: 79-87.
    • (1994) Scand. J. Immunol , vol.39 , pp. 79-87
    • Haury, M.1    Grandien, A.2    Sundblad, A.3    Coutinho, A.4    Nobrega, A.5
  • 47
    • 0027524434 scopus 로고
    • Global analysis of antibody repertoires II Evidence for specificity, self-selection and the immunological "homunculus" of antibodies in normal serum
    • Nobrega, A., Haury, M., Grandien, A., Malanchere, E., Sundblad, A. and Coutinho, A., Global analysis of antibody repertoires II Evidence for specificity, self-selection and the immunological "homunculus" of antibodies in normal serum. Eur. J. Immunol. 1993. 23: 2851-2859.
    • (1993) Eur. J. Immunol , vol.23 , pp. 2851-2859
    • Nobrega, A.1    Haury, M.2    Grandien, A.3    Malanchere, E.4    Sundblad, A.5    Coutinho, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.