Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection

European Journal of Immunology

Volumn 31, Issue 2, 2001, Pages 634-645

  Santos Lima, Eduardo César ^a   Vasconcellos, Rita ^a,c   Reina San Martín, Bernardo ^a   Fesel, Constantin ^b   Cordeiro da Silva, Anabela ^a,d   Berneman, Armand ^b   Cosson, Alain ^a   Coutinho, Antonio ^b   Minoprio, Paola ^a  

^a INSTITUT PASTEUR   (France)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

B cell repertoire; Natural antibody; Trypanosoma cruzi; Xid

Indexed keywords

HEART ANTIGEN; HEART MUSCLE EXTRACT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; B LYMPHOCYTE; CARDIOMYOPATHY; CELL MATURATION; CONTROLLED STUDY; DISEASE SEVERITY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNITY; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOREGULATION; INFECTION RESISTANCE; INFECTION SENSITIVITY; MOUSE; MOUSE STRAIN; MUTATION; NONHUMAN; PATHOGENESIS; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; ANTIBODIES, PROTOZOAN; B-LYMPHOCYTES; CHAGAS DISEASE; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, NATURAL; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC DEFICIENCY SYNDROMES; LINKAGE (GENETICS); MICE; MICE, INBRED BALB C; TRYPANOSOMA CRUZI; X CHROMOSOME;

EID: 0035109255     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200102)31:2<634::AID-IMMU634>3.0.CO;2-H     Document Type: Article

References (49)

1. Imunopatologia
2. Immunobiology of murine T. cruzi infection: The predominance of parasite-nonspecific responses and the activation of TCRI T cells
3. Measurement of parasite-specific immune responses in vitro: Evidence for suppression of the antibody response to Trypanosoma cruzi
4. Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T and B cell responses
5. A B cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
6. Chagas' disease and the autoimmune hypothesis
7. Parasite persistance correlate with disease severity and localization in chronic Chagas' disease
8. Mimicry in Trypanosoma cruzi: Fantasy and reality
9. Autoimmunity: Polyclonal activation or antigen induction?
10. From an antigen-centered, clonal perspective of autonomous activity in a self-referencial immune system
11. Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease
12. Xid-associated resistance to experimental Chagas'disease is IFN-γ-dependent
13. Vβ6-bearing cells are involved in resistance to Trypanosoma cruzi infection in XID mice
14. Defective B cell development and function in Btk-deficient mice
15. lymphocyte immune defect in CBA/N mice
16. X-linked immunodeficiency (xid) of CBA/N mice
17. The CBA/N mouse strain: An experimental model illustrating the influence of the X-chromosome on immunity
18. The Ly-1 B cell population in normal, immunodeficient and autoimmune mice
19. CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine (btk) as a regulator of CD38 indyuced signal transduction
20. The Ly-1 B cell lineage
21. Mutual cell interaction and the selection of immune repertoires
22. - T cells in the polyclonal lymphocyte responses to murine Trypanosoma cruzi infection
23. Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice
24. The Xid defect determines an improved clinical course of murine leishmaniasis in susceptible mice
25. Mice with the Xid B cell defect are less susceptible to developing Staphylococcus aureus-induced arthritis
26. Natural antibodies and the immune response
27. A current increasing of natural antibodies and enhancement of resistance of furonculosis in rainbow trout
28. Persistance of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas' disease
29. Global analysis of antibody repertoires. I. An immunoblot method for the quantitative screening of a large number of reactivities
30. Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological "homunculus" of antibodies in normal serum
31. Observations on the mode of action of normal immunoglobulin at high doses
32. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults
33. Dynamics of serum IgM autoreactive repertoires following immunization: Strain specificity, inheritance and association with autoimmune disease susceptibility
34. Instability of natural antibody repertoires in systemic lupus erythematosus patients, revealed by multiparametric analysis of serum antibody reactivities
35. Reactions among IgM antibodies derived from normal, neonatal mice
36. Studies on the T cell dependence of natural IgM and IgG antibody repertoires in adult mice
37. Most B cells in acute Trypanosoma cruzi infection lacks parasite specificity
38. Natural antibodies: From "horror autotoxicus" to "gnothi seauton"
39. Expression and control of the natural autoreactive IgG repertoire in normal human serum
40. Hidden high-avidity anti-DNA antibodies occur in normal human gammablobulin preparations
41. Ability of the Xid gene to prevent autoimmunitu in (NZB xNZB)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA
42. Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese mice
43. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
44. Natural auto-antibodies
45. Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing and phagocytosis by human monocytes
46. Induction of a systemic lupus-erythematosus-like disease in mice by a common human anti-DNA idiotype
47. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader