Apoptosis differentially regulates mesenteric and subcutaneous lymph node immune responses to Trypanosoma cruzi

European Journal of Immunology

Volumn 38, Issue 1, 2008, Pages 139-146

  de Meis, Juliana ^a,b   Ferreira, Lidia M S ^a   Guillermo, Landi V C ^a   Silva, Elisabeth M ^a   DosReis, George A ^a   Lopes, Marcela de Freitas ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Caspase 9; Chagas' disease; Cytokines; Lymph nodes; T cells

Indexed keywords

CASPASE; CASPASE 9 INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; IN VITRO STUDY; LYMPH NODE; LYMPHADENECTOMY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; SUBCUTANEOUS LYMPH NODE; T LYMPHOCYTE; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; APOPTOSIS; ATROPHY; CASPASES; CHAGAS DISEASE; CYTOKINES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MESENTERY; MICE; MICE, INBRED BALB C; SKIN; T-LYMPHOCYTES; TRYPANOSOMA CRUZI;

EID: 38349054015     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737582     Document Type: Article

References (44)

1. Brener, Z. and Gazzinelli, R. T., Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Allergy Immunol. 1997. 114: 103-110.
2. Minoprio, P. M., Coutinho, A., Joskowicz, M., D'Imperio Lima, M. R. and Eisen, H., Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II, Cytotoxic T lymphocytes. Scand. J. Immunol. 1986. 24: 669-679.
3. Minoprio, P., Parasite polyclonal activators: New targets for vaccination approaches? Int. J. Parasitol. 2001. 31: 588-591.
4. Minoprio, P. M., Eisen, H., Forni, L., D'Imperio Lima, M. R., Joskowicz, M. and Coutinho, A., Polyclonal lymphocyte responses to routine Trypanosoma cruzi infection. I. Quantitation of both T- and B-cell responses. Scand. J. Immunol. 1986. 24: 661-668.
5. + lymphocytes increase in vivo susceptibility to Trypanosoma cruzi infection. Cell. Immunol. 1996. 170: 41-53.
6. Abrahamsohn, I. A. and Coffman, R. L., Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection. Exp. Parasitol. 1996. 84: 231-244.
7. Tarleton, R. L., Grusby, M. J. and Zhang, L., Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol. 2000. 165: 1520-1525.
8. Hunter, C. A., Ellis-Neyes, L. A., Slifer, T., Kanaly, S., Grunig, G., Fort, M., Rennick, D. and Araujo, F. G., IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J. Immunol. 1997. 158: 3311-3316.
9. Rottenberg, M. E., Bakhiet, M., Olsson, T., Kristensson, K., Mak, T., Wigzell, H. and Orn, A., Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect. Immun. 1993. 61: 5129-5133.
10. Tarleton, R. L., Grusby, M. J., Postan, M. and Glimcher, L. H., Trypanosoma cruzi infection in MHC-deficient mice: Further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int. Immunol. 1996. 8: 13-22.
11. Martins, G. A., Cardoso, M. A., Aliberti, J. C. and Silva, J. S., Nitric oxide-induced apoptotic cell death in the acute phase of Trypanosoma cruzi infection in mice. Immunol. Lett. 1998. 63: 113-120.
12. Tarleton, R. L., Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. J. Immunol. 1988. 140: 2769-2773.
13. Lopes, M. F. and dos Reis, G. A., Trypanosoma cruzi-induced immunosuppression: Blockade of costimulatory T-cell responses in infected hosts due to defective T-cell receptor-CD3 functioning. Infect. Immun. 1994. 62: 1484-1488.
14. + T cell death by apoptosis in experimental Chagas' disease. J. Immunol. 1995. 154: 744-752.
15. Zuniga, E., Motran, C., Montes, C. L., Diaz, F. L., Bocco, J. L. and Gruppi, A., Trypanosoma cruzi-induced immunosuppression: B cells undergo spontaneous apoptosis and lipopolysaccharide (LPS) arrests their proliferation during acute infection. Clin. Exp. Immunol. 2000. 119: 507-515.
16. + B lymphocytes susceptible to Fas/Fas ligand-mediated fratricide. J. Immunol. 2002. 168: 3965-3973.
17. de Meis, J., Mendes-da-Cruz, D. A., Farias-de-Oliveira, D. A., Correa-de-Santana, E., Pinto-Mariz, F., Cotta-de-Almeida, V., Bonomo, A. and Savino, W., Atrophy of mesenteric lymph nodes in experimental Chagas' disease: Differential role of Fas/Fas-L and TNFRI/TNF pathways. Microbes Infect. 2006. 8: 221-231.
18. Leguizamon, M. S., Mocetti, E., Garcia Rivello, H., Argibay, P. and Campetella, O., Trans-sialidase from Tryponosoma cruzi induces apoptosis in cells from the immune system in vivo. J. Infect. Dis. 1999. 180: 1398-1402.
19. Zhang, J., Andrade, Z. A., Yu, Z. X., Andrade, S. G., Takeda, K., Sadirgursky, M. and Ferrans, V. J., Apoptosis in a canine model of acute Chagasic myocarditis. J. Mol. Cell. Cardiol. 1999. 31: 581-596.
20. Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B., Bozza, P. T., Castro-Faria-Neto, H. C., de Mello, F. G., DosReis, G. A. and Lopes, M. F., Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages, Nature 2000. 403: 199-203.
21. + T lymphocytes from infected hosts. J. Immunol. 1998. 160: 1313-1319.
22. Lopes, M. F., Freire-de-Lima, C. G. and DosReis, G. A., The macrophage haunted by cell ghosts: Apathogen grows. Immunol. Today 2000. 21: 489-494.
23. Garside, P., Millington, O. and Smith, K. M., The anatomy of mucosal immune responses. Ann. N. Y. Acad. Sci. 2004. 1029: 9-15.
24. + T cells isolated from mucosal and systemic lymphoid organs. Immunology 1993. 80: 574-580.
25. Bras, M., Queenan, B. and Susin, S. A., Programmed cell death via mitochondria: Different modes of dying. Biochemistry (Mosc) 2005. 70: 231-239.
26. Lenardo, M. J., Molecular regulation of T lymphocyte homeostasis in the healthy and diseased immune system. Immunol. Res. 2003. 27: 387-398.
27. Adam-Klages, S., Adam, D., Janssen, O. and Kabelitz, D., Death receptors and caspases: Role in lymphocyte proliferation, cell death, and auto-immunity. Immunol. Res. 2005. 33: 149-166.
28. Curtin, J. F. and Cotter, T. G., Live and let die: Regulatory mechanisms in Fas-mediated apoptosis. Cell. Signal. 2003. 15: 983-992.
29. Lenardo, M., Chan, K. M., Hornung, F., McFarland, H., Siegel, R., Wang, J. and Zheng, L., Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 1999. 17: 221-253.
30. Johnson, C. R. and Jarvis, W. D., Caspase-9 regulation: An update. Apoptosis 2004. 9: 423-427.
31. Silva, E. M., Guillermo, L. V., Ribeiro-Gomes, F. L., De Meis, J., Nunes, M. P., Senra, J. F., Soares, M. B. et al., Caspase inhibition reduces lymphocyte apoptosis and improves host immune responses to Trypanosoma cruzi infection. Eur. J. Immunol. 2007. 37: 738-746.
32. Lopes, M. F., Guillermo, L. V. and Silva, E. M., Decoding caspase signaling in host immunity to the protozoan Trypanosoma cruzi. Trends Immunol. 2007. 28: 366-372.
33. Silva, E. M., Guillermo, L. V., Ribeiro-Gomes, F. L., De Meis, J., Pereira, R. M., Wu, Z., Calegari-Silva, T. C. et al., Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection. J. Immunol. 2005. 174: 6314-6321.
34. Zheng, L., Trageser, C. L., Willerford, D. M. and Lenardo, M. J., T cell growth cyrokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death. J. Immunol. 1998. 160: 763-769.
35. Strasser, A. and Pellegrini, M., T-lymphocyte death during shutdown of an immune response. Trends Immunol. 2004. 25: 610-615.
36. Strasser, A., Puthalakath, H., Bouillet, P., Huang, D. C., O'Connor, L., O'Reilly, L. A., Cullen, L. et al., The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann. N. Y. Acad. Sci. 2000. 917: 541-548.
37. Hildeman, D. A., Zhu, Y., Mitchell, T. C., Bouillet, P., Strasser, A., Kappler, J. and Marrack, P., Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity 2002. 16: 759-767.
38. Barry, M. and Beackley, R., Cytotoxic T lymphocytes: All roads lead to death. Nat. Rev. Immunol. 2002. 2: 401-409.
39. Boatright, K. and Salvesen, G., Mechanisms of caspase activation. Curr. Opin. Cell Biol. 2003. 15: 725-731.
40. Guillermo, L. V., Silva, E. M., Ribeiro-Gomes, F. L., De Meis, J., Pereira, W. F., Yagita, H., Dosreis, G. A. and Lopes, M. F., The Fas death pathway controls coordinated expansions of type 1 CD8 and type 2 CD4 T cells in Trypanosoma cruzi infection. J. Leukoc. Biol. 2007. 81: 942-951.
41. Siegel, R. M., Caspases at the crossroads of immune-cell life and death. Nat. Rev. Immunol. 2006. 6: 308-317.
42. Wu, Z., Roberts, M., Porter, M., Walker, F., Wherry, E. J., Kelly, J., Gadina, M. et al., Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J. Immunol. 2004. 172: 6313-6323.
43. Su, H., Bidere, N., Zheng, L., Cubre, A., Sakai, K., Dale, J., Salmena, L. et al., Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 2005. 307: 1465-1468.
44. DosReis, G. A., Ribeiro-Gomes, F. L., Guillermo, L. V. and Lopes, M. F., Cross-talk between apoptosis and cytokines in the regulation of parasitic infection. Cytokine Growth Factor Rev. 2007. 18: 97-105.