Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro

Journal of Biological Chemistry

Volumn 280, Issue 24, 2005, Pages 23114-23121

  Bergström, Ann Louise ^a   Cordes, Henriette ^a   Zsurger, Nicole ^b   Heegaard, Peter M H ^a   Laursen, Henning ^c   Chabry, Joëlle ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; NEUROLOGY; PATHOLOGY; POLYPEPTIDES; TOXICITY;

AMIDATION; ELECTRORETINOGRAPHIC RECORDINGS; NEUROTOXICITY; STRUCTURAL RELAXATION;

PROTEINS;

ISOPROTEIN; PRION PROTEIN; PRION PROTEIN[106-126]; THIOFLAVINE; UNCLASSIFIED DRUG;

AMIDATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELECTRORETINOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN VARIANT; RAT; RETINA NERVE CELL;

AMYLOID; ANIMALS; APOPTOSIS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; ELECTRORETINOGRAPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; OXYGEN; PEPTIDES; PRIONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; RATS; RECOMBINANT PROTEINS; RETINA; RNA, MESSENGER; SALTS; SPECTROMETRY, FLUORESCENCE; THIAZOLES; TIME FACTORS;

EID: 20744456278     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500210200     Document Type: Article

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