The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 2, 2010, Pages 850-859

  Yang, Mon Yuan ^a   Peng, Chiung Huei ^b   Chan, Kuei Chuan ^c   Yang, Y I Sun ^c   Huang, Chien Ning ^c   Wang, Chau Jong ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Amp activated protein kinase; Hibiscus sabdariffa polyphenols; LDL; LDL receptor; Sterol regulatory element binding protein

Indexed keywords

ANTILIPEMIC AGENT; FATTY ACID SYNTHASE; FLAVONOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL STRAIN HEPG2; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HIBISCUS; HUMAN; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; METABOLISM; SYRIAN HAMSTER;

ANIMALS; ANTILIPEMIC AGENTS; CRICETINAE; DOWN-REGULATION; FATTY ACID SYNTHETASE COMPLEX; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HIBISCUS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPID METABOLISM; LIPIDS; LIPOGENESIS; LIVER; MALE; MESOCRICETUS; PHENOLS; PLANT EXTRACTS;

HIBISCUS; HIBISCUS SABDARIFFA;

EID: 74849134733     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf903209w     Document Type: Article

References (39)

1. (1) Friis, L. I.; Aldenborg, F.; Jerlstad, P.; Rundstrom, K.; Bjornsson, E. High prevalence of metabolic complications in patients with non-alcoholic fatty liver disease. Scand. J. Gastroenterol. 2004, 39, 864-869. (Pubitemid 39215458)
2. Preiss, D.; Sattar, N. Prevalence of non-alcoholic fatty liver disease: population based study. Clin. Sci. 2008, 115, 141-150.
3. Wang, P. W.; Hsieh, C. J.; Psang, L. C.; Liou, C. W.; Weng, S. W.; Chen, J. F.; Chen, I. Y.; Li, R. H.; Eng, H. L. Fatty liver and chronic inflammation in Chinese adults. Diabetes Res. Clin. Pract. 2008, 81, 202-208.
4. (4) Kim, H. J.; Miyazaki, M., Man, W. C.; Ntambi, J. M. Sterol regulatory element-binding proteins (SREBPs) as regulatory of lipid metabolism: polyunsaturated fatty acids oppose cholesterolmediated induction of SREBP-1 maturation. Ann. N. Y. Acad. Sci. 2002, 967, 34-42. (Pubitemid 34721891)
5. Bennett, M. K.; Seo, Y. K.; Datta, S.; Shin, D. J.; Osborne, T. F. Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J. Biol. Chem. 2008, 283, 15628-15637.
6. (6) Ali, B. H.; Naser, Al Wabel, N.; Blunden, G. Phytochemical, Pharmacological and Toxicological Aspects of Hibiscus sabdariffa L.: A Review. Phytother. Res. 2005, 19, 369-375. (Pubitemid 41285001)
7. Fuhrman, B.; Nitzan, O.; Karry, R.; Volkova, N.; Dumler, I.; Aviram, M, Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner. Atherosclerosis 2007, 195, 108-116.
8. Soundararajan, R.; Wishart, A. D.; Rupasinghe, H. P.; ArcellanaPanlilio, M.; Nelson, C. M.; Mayne, M.; Robertson, G. S. Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J. Biol. Chem. 2008, 283, 2231-2245.
9. Park, K. G.; Min, A. K.; Koh, E. H.; Kim, H. S.; Kim, M. O.; Park, H. S.; Kim, Y. D.; Yoon, T. S.; Jang, B. K.; Hwang, J. S.; Kim, J. B.; Choi, H. S.; Park, J. Y.; Lee, I. K.; Lee, K. U. Alphalipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Henatology 2008, 48, 1477-1486.
10. (10) Zhou, G.; Myers, R.; Li, Y.; Chen, Y.; Shen, X.; Fenyk-Melody, J.; Wu, M.; Ventre, J.; Doebber, T.; Fujii, N.; Musi, N.; Hirshman, M. F.; Goodyear, L. J.; Moller, D. E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001, 108, 1167-1174. (Pubitemid 32995375)
11. Puljak, L.; Parameswara, V.; Dolovcak, S.; Waldrop, S. L.; Emmett, D.; Esser, V.; Fitz, J. G.; Kilic, G. Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. EXP. Cell Res. 2008, 314, 2100-2109.
12. Yang, J.; Maika, S.; Craddock, L.; King, J. A.; Liu, Z. M. Chronic activation of AMP-activated protein kinase-alphal in liver leads to decreased adiposity in mice. Biochem. Biophys. Res. Commun. 2008, 370, 248-253.
13. Chen, C. C.; Hsu, J. D.; Wang, S. F.; Chiang, H. C.; Yang, M. Y.; Kao, E. S.; Ho, Y. C.; Wang, C. J. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J. Agric. Food Chem. 2003, 51, 5472-5477.
14. Chen, C. C.; Chou, F. P.; Ho, Y. C.; Lin, W. L.; Wang, C. P.; Hao, E. S.; Huang, A. C.; Wang, C. J. Inhibitory effects of Hibiscus Sabdarriffa L. extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats. J. Sci. Food Agric. 2004, 84, 1989-1996.
15. Lin, T. L.; Lin, H. H.; Chen, C. C.; Lin, M. C.; Chou, M. C.; Wang, C. J. Hibiscus sabdariffa extract reduces serum cholesterol in men and womrn. Nutr. Res. (N. Y.) 2007, 27, 140-145.
16. Osborne, T. F. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. [Review]. J. Biol. Chem. 2000, 275, 32379-32382.
17. Chang, Y. C.; Huang, H, P.; Hsu, J. D.; Yang, S. F.; Wang, C. J. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxickol. Appl. Pharmacol 2005, 205, 201-212.
18. Lo, C. W.; Huang, H. P.; Lin, H. M.; Chien, C. T.; Wang, C. J. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol. Nutr. Food.Res. 2007, 51, 1452-1460.
19. Lin, H. H.; Huang, H. P.; Huang, C. C.; Chen, J. H.; Wang, C. J. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol. Carcinog. 2007, 43, 86-99.
20. Huang, C. N.; Chan, K. C.; Lin, W. T.; Su, S. L.; Wang, C. J.; Peng, C. H. Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose - a mechanism involves connective tissue growth factor signals. J. Agric. Food Chem. 2009, 57, 3073-3079.
21. Folch, J.; Lees, M.; Sloane, Stanley G. H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226, 497-509.
22. Mende, A. J.; Oram, J. F.; Bierman, E. L. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J. Biol. Chem. 1991, 266, 10104-10111.
23. Henin, N.; Vincent, M. F.; Gruber, H. E.; Van den Berghe, G. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J. 1995, 9, 541-546.
24. (24) Hardie, D. G.; Pan, D. A. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase, Biochem. Soc. Trans. 2002, 30, 1064-1070. (Pubitemid 36002407)
25. .Dobrzyn, P.; Dobrzyn, A.; Miyazaki, M.; Cohen, P.; Asilmaz, E.; Hardie, D. G.; Friedman, J. M.; Ntambi, J. M. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6409-6414.
26. Gaidhu, M. P.; Fediuc, S.; Ceddia, R. B. 5-Aminoimidazole4-carboxamide-l- beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulinstimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. J. Biol. Chem. 2006, 281, 25956-25964.
27. Foretz, M.; Ancellin, N.; Andreelli, F.; Saintillan, Y.; Grondin, P.; Kahn, A.; Thorens, B.; Vaulont, S.; Viollet, B. Short-term, overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 2005, 54, 1331-1339.
28. Diraison, F.; Parton, L.; Ferre, P.; Foufelle, F.; Briscoe, C. P.; Leclerc, I.; Rutter, G. A. Over-expression of sterol-regulatoryelement-binding protein-lc (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem. J. 2004, 378, 769-778.
29. Gouni-Berthold, I.; Krone, W. Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis. Curr. Drug Targets 2005, 5, 513-523.
30. Fruchart, J. C.; Duriez, P. Mode of action of fibrates in the regulation, of triglyceride and HDL-cholesterol metabolism. Drugs Today 2006, 42, 39-64.
31. Brian, N. F.; Daniel, P. K. Peroxisome Proliferator-activated Receptor a (PPARa) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart. J. Mol. Cell. Cardiol. 2002, 34, 1249-1257.
32. (32) Suzuki, A.; Okamoto, S.; Lee, S.; Saito, K.; Shiuchi, T.; Minokoshi, Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol. Cell. Biol. 2007, 27, 4317-4327. (Pubitemid 46906556)
33. Yoon, M. J.; Lee, G. Y.; Chung, J. J.; Ahn, Y. H.; Hong, S. H.; Kim, J. B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006, 55, 2562-2570.
34. Huang, Z.; Zhou, X.; Nicholson, A. C.; Gotto, A. M., Jr.; Hajjar, D. P.; Han, J. Activation of peroxisome proliferator-activated receptoralpha in mice induces expression of the hepatic low-density lipoprotein receptor. Br. J. Pharmacol. 2008, 155, 596-605.
35. (35) Konig, B.; Koch, A.; Spielmann, J.; Hilgenfeld, C.; Stangl, G. I.; Eder, K. Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem. Pharmacol. 2007, 73, 574-585. (Pubitemid 46038856)
36. 4-induced liver fibrosis in rats. Food Chem. Toxicol. 2006, 44, 336-343.
37. Tamura, A.; Fukushima, M.; Shimada, K, I.; Han, K. H.; Sekikawa, M.; Watanabe, S.; Nakano, N.; Matsumoto, M.; Chiji, H. Cholesterol metabolism in rat is affected by protocatechuic acid. J. Nutr. Sci. Vitaminol. 2004, 50, 13-1.8.
38. Karthikesan, K.; Pari, L. Caffeic acid alleviates the increased lipid levels of serum and tissues in alcohol-induced rats. Fundam. Clin. Pharmacol. 2008, 22, 523-527.
39. Lee, S. M.; Kim, C. W.; Kim, J. K.; Shin, H. J.; Baik, J. H. GCGrich tea catechins are effective in lowering cholesterol and triglyceride concentrations in hyperlipidemic rats. Lipids 2008, 43, 419-429.