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Volumn 155, Issue 4, 2008, Pages 596-605

Activation of peroxisome proliferator-activated receptor-α in mice induces expression of the hepatic low-density lipoprotein receptor

Author keywords

Akt; Fenofibrate; LDLR; PPAR ; SREBP2

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 2 CHLORO 5 NITROBENZANILIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; FENOFIBRATE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

EID: 53849106812     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.331     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 0141591549 scopus 로고    scopus 로고
    • Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
    • Adams CM, Goldstein JL, Brown MS (2003). Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proc Natl Acad Sci USA 100: 10647-10652.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10647-10652
    • Adams, C.M.1    Goldstein, J.L.2    Brown, M.S.3
  • 2
    • 9444234519 scopus 로고    scopus 로고
    • Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor α, retinoid X receptor, and liver X receptor in mouse liver
    • Anderson SP, Dunn C, Laughter A, Yoon L, Swanson C, Stulnig TM et al. (2004). Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor α, retinoid X receptor, and liver X receptor in mouse liver. Mol Pharmacol 66: 1440-1452.
    • (2004) Mol Pharmacol , vol.66 , pp. 1440-1452
    • Anderson, S.P.1    Dunn, C.2    Laughter, A.3    Yoon, L.4    Swanson, C.5    Stulnig, T.M.6
  • 3
    • 35248884433 scopus 로고    scopus 로고
    • Comparison of atorvastatin versus fenofibrate in reaching lipid targets and influencing biomarkers of endothelial damage in patients with familial combined hyperlipidemia
    • Arca M, Montali A, Pigna G, Antonini R, Antonini TM, Luigi P et al. (2007). Comparison of atorvastatin versus fenofibrate in reaching lipid targets and influencing biomarkers of endothelial damage in patients with familial combined hyperlipidemia. Metabolism 56: 1534-1541.
    • (2007) Metabolism , vol.56 , pp. 1534-1541
    • Arca, M.1    Montali, A.2    Pigna, G.3    Antonini, R.4    Antonini, T.M.5    Luigi, P.6
  • 4
    • 0036636769 scopus 로고    scopus 로고
    • Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia
    • Athyros VG, Papageorgiou AA, Athyrou VV, Demitriadis DS, Kontopoulos AG (2002). Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia. Diabetes Care 25: 1198-1202.
    • (2002) Diabetes Care , vol.25 , pp. 1198-1202
    • Athyros, V.G.1    Papageorgiou, A.A.2    Athyrou, V.V.3    Demitriadis, D.S.4    Kontopoulos, A.G.5
  • 6
    • 0242490816 scopus 로고    scopus 로고
    • Pharmacotherapy for dyslipidaemia - current therapies and future agents
    • Bays H, Stein EA (2003). Pharmacotherapy for dyslipidaemia - current therapies and future agents. Expert Opin Pharmacother 4: 1901-1938.
    • (2003) Expert Opin Pharmacother , vol.4 , pp. 1901-1938
    • Bays, H.1    Stein, E.A.2
  • 7
    • 8944252340 scopus 로고    scopus 로고
    • Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice
    • Berthou L, Duverger N, Emmanuel F, Langouet S, Auwerx J, Guillouzo A et al. (1996). Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. J Clin Invest 97: 2408-2416.
    • (1996) J Clin Invest , vol.97 , pp. 2408-2416
    • Berthou, L.1    Duverger, N.2    Emmanuel, F.3    Langouet, S.4    Auwerx, J.5    Guillouzo, A.6
  • 8
    • 0141643289 scopus 로고    scopus 로고
    • Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation
    • Borradaile NM, De Dreu LE, Huff MW (2003). Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes 52: 2554-2561.
    • (2003) Diabetes , vol.52 , pp. 2554-2561
    • Borradaile, N.M.1    De Dreu, L.E.2    Huff, M.W.3
  • 9
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown MS, Goldstein JL (1997). The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 11
    • 34250351903 scopus 로고    scopus 로고
    • Combination therapy of low-dose atorvastatin and fenofibrate in mixed hyperlipidemia
    • Chatley P, Badyal DK, Calton R, Khosla PP (2007). Combination therapy of low-dose atorvastatin and fenofibrate in mixed hyperlipidemia. Methods Find Exp Clin Pharmacol 29: 217-221.
    • (2007) Methods Find Exp Clin Pharmacol , vol.29 , pp. 217-221
    • Chatley, P.1    Badyal, D.K.2    Calton, R.3    Khosla, P.P.4
  • 12
  • 13
    • 10444268083 scopus 로고    scopus 로고
    • Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: A 12-month, randomized, double-blind, controlled trial
    • Derosa G, Cicero AE, Bertone G, Piccinni MN, Ciccarelli L, Roggeri DE (2004). Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial. Clin Ther 26: 1599-1607.
    • (2004) Clin Ther , vol.26 , pp. 1599-1607
    • Derosa, G.1    Cicero, A.E.2    Bertone, G.3    Piccinni, M.N.4    Ciccarelli, L.5    Roggeri, D.E.6
  • 14
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK et al. (2005). Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366: 1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3    Erdmann, E.4    Massi-Benedetti, M.5    Moules, I.K.6
  • 15
    • 33744732467 scopus 로고    scopus 로고
    • Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis
    • Du X, Kristiana I, Wong J, Brown AJ (2006). Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis. Mol Biol Cell 17: 2735-2745.
    • (2006) Mol Biol Cell , vol.17 , pp. 2735-2745
    • Du, X.1    Kristiana, I.2    Wong, J.3    Brown, A.J.4
  • 16
    • 2242436246 scopus 로고    scopus 로고
    • Reduction of atherosclerosis by the peroxisome proliferator-activated receptor a agonist fenofibrate in mice
    • Duez H, Chao YS, Heranandez M, Torpier G, Poulain P, Mundt S et al. (2002). Reduction of atherosclerosis by the peroxisome proliferator-activated receptor a agonist fenofibrate in mice. J Biol Chem 277: 48051-48057.
    • (2002) J Biol Chem , vol.277 , pp. 48051-48057
    • Duez, H.1    Chao, Y.S.2    Heranandez, M.3    Torpier, G.4    Poulain, P.5    Mundt, S.6
  • 17
    • 0035191701 scopus 로고    scopus 로고
    • Effects of atorvastatin versus fenofibrate on lipoprotein profiles, low-density lipoprotein subfraction distribution, and hemorheologic parameters in type 2 diabetes mellitus with mixed hyperlipoproteinemia
    • Frost RJ, Otto C, Geiss HC, Schwandt P, Parhofer KG (2001). Effects of atorvastatin versus fenofibrate on lipoprotein profiles, low-density lipoprotein subfraction distribution, and hemorheologic parameters in type 2 diabetes mellitus with mixed hyperlipoproteinemia. Am J Cardiol 87: 44-48.
    • (2001) Am J Cardiol , vol.87 , pp. 44-48
    • Frost, R.J.1    Otto, C.2    Geiss, H.C.3    Schwandt, P.4    Parhofer, K.G.5
  • 18
    • 33750440787 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors at the crossroads of obesity, diabetes, and cardiovascular disease
    • Gilde AJ, Fruchart JC, Staels B (2006). Peroxisome proliferator-activated receptors at the crossroads of obesity, diabetes, and cardiovascular disease. J Am Coll Cardiol 48: A24-A32.
    • (2006) J Am Coll Cardiol , vol.48
    • Gilde, A.J.1    Fruchart, J.C.2    Staels, B.3
  • 19
  • 20
    • 13844272245 scopus 로고    scopus 로고
    • Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial)
    • Grundy SM, Vega GL, Yuan Z, Battisti WP, Brady WE, Palmisano J (2005). Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial). Am J Cardiol 95: 462-468.
    • (2005) Am J Cardiol , vol.95 , pp. 462-468
    • Grundy, S.M.1    Vega, G.L.2    Yuan, Z.3    Battisti, W.P.4    Brady, W.E.5    Palmisano, J.6
  • 21
    • 10044279170 scopus 로고    scopus 로고
    • Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104)
    • Han J, Parsons M, Zhou X, Nicholson AC, Gotto Jr AM, Hajjar DP (2004). Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104). Circulation 110: 3472-3479.
    • (2004) Circulation , vol.110 , pp. 3472-3479
    • Han, J.1    Parsons, M.2    Zhou, X.3    Nicholson, A.C.4    Gotto Jr, A.M.5    Hajjar, D.P.6
  • 22
    • 24144476576 scopus 로고    scopus 로고
    • PPARα, but not PPARγ, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia
    • Hennuyer N, Tailleux A, Toppier G, Mezdour H, Fruchart JC, Staels B et al. (2005). PPARα, but not PPARγ, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia. Arterioscler Thromb Vasc Biol 25: 1897-1902.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1897-1902
    • Hennuyer, N.1    Tailleux, A.2    Toppier, G.3    Mezdour, H.4    Fruchart, J.C.5    Staels, B.6
  • 23
    • 33746122627 scopus 로고    scopus 로고
    • Atorvastatin or fenofibrate on post-prandial lipaemia in type 2 diabetic patients with hyperlipidaemia
    • Iovine C, Lilli S, Gentile A, Patti L, Di ML, Cipriano P et al. (2006). Atorvastatin or fenofibrate on post-prandial lipaemia in type 2 diabetic patients with hyperlipidaemia. Eur J Clin Invest 36: 560-565.
    • (2006) Eur J Clin Invest , vol.36 , pp. 560-565
    • Iovine, C.1    Lilli, S.2    Gentile, A.3    Patti, L.4    Di, M.L.5    Cipriano, P.6
  • 24
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech A, Simes RJ, Barter P, Best J, Scott R, Taskinen MR et al. (2005). Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366: 1849-1861.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3    Best, J.4    Scott, R.5    Taskinen, M.R.6
  • 25
    • 44349177547 scopus 로고    scopus 로고
    • Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/Kexin type 9
    • Kourimate S, Le May C, Langhi C, Jarnoux AL, Ouguerram K, Zaïr Y et al. (2008). Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/Kexin type 9. J Biol Chem 283: 9666-9673.
    • (2008) J Biol Chem , vol.283 , pp. 9666-9673
    • Kourimate, S.1    Le May, C.2    Langhi, C.3    Jarnoux, A.L.4    Ouguerram, K.5    Zaïr, Y.6
  • 26
    • 3042519202 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor α activation on pathways contributing to cholesterol homeostasis in rat hepatocytes
    • Le Jossic-Corcos C, Duclos S, Ramirez LC, Zaghini I, Chevillard G, Marti P et al. (2004). Effects of peroxisome proliferator-activated receptor α activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. Biochim Biophys Acta 1683: 49-58.
    • (2004) Biochim Biophys Acta , vol.1683 , pp. 49-58
    • Le Jossic-Corcos, C.1    Duclos, S.2    Ramirez, L.C.3    Zaghini, I.4    Chevillard, G.5    Marti, P.6
  • 27
    • 18444412555 scopus 로고    scopus 로고
    • Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662
    • Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG et al. (2002). Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41: 6640-6650.
    • (2002) Biochemistry , vol.41 , pp. 6640-6650
    • Leesnitzer, L.M.1    Parks, D.J.2    Bledsoe, R.K.3    Cobb, J.E.4    Collins, J.L.5    Consler, T.G.6
  • 28
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • Li AC, Brown KK, Silvestre MJ, Willson TM, Palinski W, Glass CK (2000). Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 106: 523-531.
    • (2000) J Clin Invest , vol.106 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 29
    • 0034782457 scopus 로고    scopus 로고
    • Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial - FAT)
    • Malik J, Melenovsky V, Wichterle D, Haas T, Simek J, Ceska R et al. (2001). Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial - FAT). Cardiovasc Res 52: 290-298.
    • (2001) Cardiovasc Res , vol.52 , pp. 290-298
    • Malik, J.1    Melenovsky, V.2    Wichterle, D.3    Haas, T.4    Simek, J.5    Ceska, R.6
  • 30
    • 17444438664 scopus 로고    scopus 로고
    • Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia
    • Melenovsky V, Malik J, Wichterle D, Simek J, Pisarikova A, Skrha J et al. (2002). Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia. Am Heart J 144: E6.
    • (2002) Am Heart J , vol.144
    • Melenovsky, V.1    Malik, J.2    Wichterle, D.3    Simek, J.4    Pisarikova, A.5    Skrha, J.6
  • 31
    • 0033623539 scopus 로고    scopus 로고
    • Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
    • Motojima K (2000). Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver. Int J Biochem Cell Biol 32: 1085-1092.
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 1085-1092
    • Motojima, K.1
  • 32
    • 33745685394 scopus 로고    scopus 로고
    • The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: The DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    • Muhlestein JB, May HT, Jensen JR, Horne BD, Lanman RB, Lavasani F et al. (2006). The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study. J Am Coll Cardiol 48: 396-401.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 396-401
    • Muhlestein, J.B.1    May, H.T.2    Jensen, J.R.3    Horne, B.D.4    Lanman, R.B.5    Lavasani, F.6
  • 33
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice. Evidence for compensatory regulation by PPARd
    • Muoio DM, Maclean PS, Lang DB, Li S, Houmard JA, Way JM et al. (2002). Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice. Evidence for compensatory regulation by PPARd. J Biol Chem 277: 26089-26097.
    • (2002) J Biol Chem , vol.277 , pp. 26089-26097
    • Muoio, D.M.1    Maclean, P.S.2    Lang, D.B.3    Li, S.4    Houmard, J.A.5    Way, J.M.6
  • 34
    • 0033613126 scopus 로고    scopus 로고
    • Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
    • Nohturfft A, Bose-Boyd RA, Scheek S, Goldstein JL, Brown MS (1999). Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci USA 96: 11235-11240.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11235-11240
    • Nohturfft, A.1    Bose-Boyd, R.A.2    Scheek, S.3    Goldstein, J.L.4    Brown, M.S.5
  • 35
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T, Griffith B, Chung YL, Delpuech O, Griffith JR, Downward J et al. (2005). PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1    Griffith, B.2    Chung, Y.L.3    Delpuech, O.4    Griffith, J.R.5    Downward, J.6
  • 36
    • 3242668095 scopus 로고    scopus 로고
    • Direct binding of cholesterol to the purified membrane region of SCAP: Mechanism for a sterol-sensing domain
    • Radhakrishnan A, Sun LP, Kwon HJ, Brown MS, Goldstein JL (2004). Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell 15: 259-268.
    • (2004) Mol Cell , vol.15 , pp. 259-268
    • Radhakrishnan, A.1    Sun, L.P.2    Kwon, H.J.3    Brown, M.S.4    Goldstein, J.L.5
  • 37
    • 17844364863 scopus 로고    scopus 로고
    • The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia
    • Saklamaz A, Comlekci A, Temiz A, Caliskan S, Ceylan C, Alacacioglu A et al. (2005). The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: a comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia. Metabolism 54: 677-681.
    • (2005) Metabolism , vol.54 , pp. 677-681
    • Saklamaz, A.1    Comlekci, A.2    Temiz, A.3    Caliskan, S.4    Ceylan, C.5    Alacacioglu, A.6
  • 38
    • 0036194213 scopus 로고    scopus 로고
    • Both cerivastatin and fenofibrate improve arterial vasoreactivity in patients with combined hyperlipidaemia
    • Sebestjen M, Zegura B, Keber I (2002). Both cerivastatin and fenofibrate improve arterial vasoreactivity in patients with combined hyperlipidaemia. J Intern Med 251: 77-85.
    • (2002) J Intern Med , vol.251 , pp. 77-85
    • Sebestjen, M.1    Zegura, B.2    Keber, I.3
  • 39
    • 0034804783 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
    • Shimano H (2001). Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40: 439-452.
    • (2001) Prog Lipid Res , vol.40 , pp. 439-452
    • Shimano, H.1
  • 40
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S (2005). The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9: 59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 41
    • 0026577411 scopus 로고
    • Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat
    • Staels B, Van TA, Andreu T, Auwerx J (1992). Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat. Arterioscler Thromb 12: 286-294.
    • (1992) Arterioscler Thromb , vol.12 , pp. 286-294
    • Staels, B.1    Van, T.A.2    Andreu, T.3    Auwerx, J.4
  • 42
    • 0242322483 scopus 로고    scopus 로고
    • Adipogenic differentiating agents regulate expression of fatty acid binding protein and CD36 in the J744 macrophage cell line
    • Sun L, Nicholson AC, Hajjar DP, Gotto Jr AM, Han J (2003). Adipogenic differentiating agents regulate expression of fatty acid binding protein and CD36 in the J744 macrophage cell line. J Lipid Res 44: 1877-1886.
    • (2003) J Lipid Res , vol.44 , pp. 1877-1886
    • Sun, L.1    Nicholson, A.C.2    Hajjar, D.P.3    Gotto Jr, A.M.4    Han, J.5
  • 43
    • 0037446467 scopus 로고    scopus 로고
    • Effects of adding fenofibrate (200 mg/day) to simvastatin (10mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    • Vega GL, Ma PT, Cater NB, Filipchuk N, Meguro S, Garcia-Garcia AB et al. (2003). Effects of adding fenofibrate (200 mg/day) to simvastatin (10mg/day) in patients with combined hyperlipidemia and metabolic syndrome. Am J Cardiol 91: 956-960.
    • (2003) Am J Cardiol , vol.91 , pp. 956-960
    • Vega, G.L.1    Ma, P.T.2    Cater, N.B.3    Filipchuk, N.4    Meguro, S.5    Garcia-Garcia, A.B.6
  • 44
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
    • Vu-Dac N, Schoonjans K, Kosykh V, Dallongeville J, Fruchart JC, Staels B et al. (1995). Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest 96: 741-750.
    • (1995) J Clin Invest , vol.96 , pp. 741-750
    • Vu-Dac, N.1    Schoonjans, K.2    Kosykh, V.3    Dallongeville, J.4    Fruchart, J.C.5    Staels, B.6
  • 45
    • 0242661386 scopus 로고    scopus 로고
    • Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: Relations with baseline lipid profiles
    • Wang TD, Chen WJ, Lin JW, Cheng CC, Chen MF, Lee YT (2003). Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: relations with baseline lipid profiles. Atherosclerosis 170: 315-323.
    • (2003) Atherosclerosis , vol.170 , pp. 315-323
    • Wang, T.D.1    Chen, W.J.2    Lin, J.W.3    Cheng, C.C.4    Chen, M.F.5    Lee, Y.T.6
  • 46
    • 33645086352 scopus 로고    scopus 로고
    • FIELDS of dreams, fields of tears: A perspective on the fibrate trials
    • Wierzbicki AS (2006). FIELDS of dreams, fields of tears: a perspective on the fibrate trials. Int J Clin Pract 60: 442-449.
    • (2006) Int J Clin Pract , vol.60 , pp. 442-449
    • Wierzbicki, A.S.1
  • 47
    • 2542431095 scopus 로고    scopus 로고
    • Qualitative effect of fenofibrate and quantitative effect of atorvastatin on LDL profile in combined hyperlipidemia with dense LDL
    • Winkler K, Weltzien P, Friedrich I, Schmitz H, Nickell HH, Hauck P et al. (2004). Qualitative effect of fenofibrate and quantitative effect of atorvastatin on LDL profile in combined hyperlipidemia with dense LDL. Exp Clin Endocrinol Diabetes 112: 241-247.
    • (2004) Exp Clin Endocrinol Diabetes , vol.112 , pp. 241-247
    • Winkler, K.1    Weltzien, P.2    Friedrich, I.3    Schmitz, H.4    Nickell, H.H.5    Hauck, P.6
  • 48
    • 0027979778 scopus 로고
    • Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha
    • Wu JC, Merlino G, Fausto N (1994). Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci USA 91: 674-678.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 674-678
    • Wu, J.C.1    Merlino, G.2    Fausto, N.3
  • 49
    • 0037162719 scopus 로고    scopus 로고
    • Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    • Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R et al. (2002). Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110: 489-500.
    • (2002) Cell , vol.110 , pp. 489-500
    • Yang, T.1    Espenshade, P.J.2    Wright, M.E.3    Yabe, D.4    Gong, Y.5    Aebersold, R.6
  • 50
    • 4444248817 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activation of sterol regulatory element binding protein: A potential role in angiogenesis
    • Zhou RH, Yao M, Lee TS, Zhu Y, Martins-Green M, Shyy JY (2004). Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circ Res 95: 471-478.
    • (2004) Circ Res , vol.95 , pp. 471-478
    • Zhou, R.H.1    Yao, M.2    Lee, T.S.3    Zhu, Y.4    Martins-Green, M.5    Shyy, J.Y.6


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