메뉴 건너뛰기




Volumn 34, Issue 10, 2002, Pages 1249-1257

Peroxisome proliferator-activated receptor α (PPARα) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; CELL RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR;

EID: 0036773047     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2828(02)92061-4     Document Type: Article
Times cited : (140)

References (55)
  • 1
  • 2
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long-chain fatty acid transport prctein
    • Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long-chain fatty acid transport prctein. Cell 1994; 79: 427-436.
    • (1994) Cell , vol.79 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 3
    • 0027240176 scopus 로고
    • Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    • Abumrad NA, el-Maghrabi MR, Amri EZ, Lopez E, Grimaldi PA. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 1993; 268: 17665-17668.
    • (1993) J Biol Chem , vol.268 , pp. 17665-17668
    • Abumrad, N.A.1    El-Maghrabi, M.R.2    Amri, E.Z.3    Lopez, E.4    Grimaldi, P.A.5
  • 4
    • 0026085762 scopus 로고
    • Beta oxidation of fatty acids
    • Schulz H. Beta oxidation of fatty acids. Biochim Biophys Acta 1991; 1081: 109-120.
    • (1991) Biochim Biophys Acta , vol.1081 , pp. 109-120
    • Schulz, H.1
  • 5
    • 0024503204 scopus 로고
    • Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase
    • McGarry JD, Woeltje KF, Kuwajima M, Foster DW. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes Metab Rev 1989; 5: 271-284.
    • (1989) Diabetes Metab Rev , vol.5 , pp. 271-284
    • McGarry, J.D.1    Woeltje, K.F.2    Kuwajima, M.3    Foster, D.W.4
  • 6
    • 0029862741 scopus 로고    scopus 로고
    • Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I)
    • Esser V, Brown NF, Cowan AT, Foster DW, McGarry JD. Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). J Biol Chem 1996; 271: 6972-6977.
    • (1996) J Biol Chem , vol.271 , pp. 6972-6977
    • Esser, V.1    Brown, N.F.2    Cowan, A.T.3    Foster, D.W.4    McGarry, J.D.5
  • 7
    • 0032508696 scopus 로고    scopus 로고
    • Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α
    • Brandt J, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α. J Biol Chem 1998; 273: 23786-23792.
    • (1998) J Biol Chem , vol.273 , pp. 23786-23792
    • Brandt, J.1    Djouadi, F.2    Kelly, D.P.3
  • 8
    • 0028943364 scopus 로고
    • Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart
    • Brown NF, Weis BC, Husti JE, Foster DW, McGarry JD. Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart. J Biol Chem 1995; 270: 8952-8957.
    • (1995) J Biol Chem , vol.270 , pp. 8952-8957
    • Brown, N.F.1    Weis, B.C.2    Husti, J.E.3    Foster, D.W.4    McGarry, J.D.5
  • 9
    • 0032502704 scopus 로고    scopus 로고
    • Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor α
    • Mascaró C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor α. J Biol Chem 1998; 273: 8560-8563.
    • (1998) J Biol Chem , vol.273 , pp. 8560-8563
    • Mascaró, C.1    Acosta, E.2    Ortiz, J.A.3    Marrero, P.F.4    Hegardt, F.G.5    Haro, D.6
  • 10
    • 0032484002 scopus 로고    scopus 로고
    • Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Iβ gene promoters by fatty acid enzyme substrate
    • : 32.901-32.
    • Yu GS, Lu YC, Gulick T. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Iβ gene promoters by fatty acid enzyme substrate. J Biol Chem 1998; 273: 32.901-32.909.
    • (1998) J Biol Chem , vol.273 , pp. 909
    • Yu, G.S.1    Lu, Y.C.2    Gulick, T.3
  • 11
    • 0024837626 scopus 로고
    • The tissue-specific expression and developmental regulation of the two nuclear genes encoding rat mitochondrial proteins: Medium-chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase
    • Kelly DP, Gordon JI, Alpers R, Strauss AW. The tissue-specific expression and developmental regulation of the two nuclear genes encoding rat mitochondrial proteins: Medium-chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. J Biol Chem 1989; 264: 18921-18925.
    • (1989) J Biol Chem , vol.264 , pp. 18921-18925
    • Kelly, D.P.1    Gordon, J.I.2    Alpers, R.3    Strauss, A.W.4
  • 12
    • 0027428750 scopus 로고
    • Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat
    • Nagao M, Parimoo B, Tanaka K. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J Biol Chem 1993; 268: 24114-24124.
    • (1993) J Biol Chem , vol.268 , pp. 24114-24124
    • Nagao, M.1    Parimoo, B.2    Tanaka, K.3
  • 13
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
    • Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999; 96: 7473-7478.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 16
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • Barger PM, Kelly DP, PPAR signaling in the control of cardiac energy metabolism. Trends in Cardiovascular Medicine 2000; 10: 238-245.
    • (2000) Trends in Cardiovascular Medicine , vol.10 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 17
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocrine Reviews 1999; 20: 649-688.
    • (1999) Endocrine Reviews , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 18
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 19
    • 0034801882 scopus 로고    scopus 로고
    • Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
    • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B. Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001; 142: 4195-4202.
    • (2001) Endocrinology , vol.142 , pp. 4195-4202
    • Escher, P.1    Braissant, O.2    Basu-Modak, S.3    Michalik, L.4    Wahli, W.5    Desvergne, B.6
  • 20
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman BM, Chen J, Evans RM, Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci USA 1997; 94: 4312-4317.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 22
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey G, Braissant O, L'Horset F, Kalkhoven K, Perroud M, Parker MG, Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 1997; 11: 779-791.
    • (1997) Mol Endocrinol , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, K.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 23
    • 0034454583 scopus 로고    scopus 로고
    • Wahli W. Nuclear hormone receptor coregulators in action: Diversity for shared tasks
    • Robyr D. Wolffe AP. Wahli W. Nuclear hormone receptor coregulators in action: Diversity for shared tasks. Mol Endocrinol 2000; 14: 329-347.
    • (2000) Mol Endocrinol , vol.14 , pp. 329-347
    • Robyr, D.1    Wolffe, A.P.2
  • 24
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 25
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 2000; 20: 1868-1876.
    • (2000) Mol Cell Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 29
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice
    • , Djouadi F, Weinheimer CJ, Saffitz JE, Pitchford C, Bastin J. Gonzalez FJ, Kelly DP. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice. J Clin Invest 1998; 102: 1083-1091.
    • (1998) J Clin Invest , vol.102 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3    Pitchford, C.4    Bastin, J.5    Gonzalez, F.J.6    Kelly, D.P.7
  • 31
    • 0037040203 scopus 로고    scopus 로고
    • A role for PPARα in the control of cardiac Malonyl-CoA levels: Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARα are associated with higher concentrations of Malonyl-CoA and reduced expression of Malonyl-CoA decarboxylase
    • Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JRB, Belke DD, Severson DL, Kelly DP, Lopaschuk GD. A role for PPARα in the control of cardiac Malonyl-CoA levels: Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARα are associated with higher concentrations of Malonyl-CoA and reduced expression of Malonyl-CoA decarboxylase. J Biol Chem 2002; 277: 4098-4103.
    • (2002) J Biol Chem , vol.277 , pp. 4098-4103
    • Campbell, F.M.1    Kozak, R.2    Wagner, A.3    Altarejos, J.Y.4    Dyck, J.R.B.5    Belke, D.D.6    Severson, D.L.7    Kelly, D.P.8    Lopaschuk, G.D.9
  • 33
  • 34
    • 0029800177 scopus 로고    scopus 로고
    • Fatty acid oxidation enzyme gene expression is downregulated in the failing heart
    • Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996; 94: 2837-2842.
    • (1996) Circulation , vol.94 , pp. 2837-2842
    • Sack, M.N.1    Rader, T.A.2    Park, S.3    Bastin, J.4    McCune, S.A.5    Kelly, D.P.6
  • 35
    • 0030923761 scopus 로고    scopus 로고
    • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
    • Sack MN, Disch DL, Rockman HA, Kelly DP. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci USA 1997; 94: 6438-6443.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6438-6443
    • Sack, M.N.1    Disch, D.L.2    Rockman, H.A.3    Kelly, D.P.4
  • 37
    • 0033933236 scopus 로고    scopus 로고
    • Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth
    • Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP. Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth. J Clin Invest 2000; 105: 1723-1730.
    • (2000) J Clin Invest , vol.105 , pp. 1723-1730
    • Barger, P.M.1    Brandt, J.M.2    Leone, T.C.3    Weinheimer, C.J.4    Kelly, D.P.5
  • 38
    • 0035920140 scopus 로고    scopus 로고
    • Hypoxia inhibits the PPARa/RXR gene regulatory pathway in cardiac myocytes
    • Huss JM, Levy FH, Kelly DP. Hypoxia inhibits the PPARa/RXR gene regulatory pathway in cardiac myocytes J Biol Chem 2001; 276: 27605-27612.
    • (2001) J Biol Chem , vol.276 , pp. 27605-27612
    • Huss, J.M.1    Levy, F.H.2    Kelly, D.P.3
  • 39
    • 0035860177 scopus 로고    scopus 로고
    • Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart
    • Razeghi P, Young ME, Abbasi S, Taegtmeyer H. Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun 2001; 287: 5-10.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 5-10
    • Razeghi, P.1    Young, M.E.2    Abbasi, S.3    Taegtmeyer, H.4
  • 40
    • 0005012411 scopus 로고    scopus 로고
    • A critical role for PPARα in the preservation of cardiac function in the hypertrophied heart
    • Abstract
    • Lehman JJ, Weinheiver C, Courtois M, Kovacs A, Kelly DP. A critical role for PPARα in the preservation of cardiac function in the hypertrophied heart. Circulation 2001; 140(Suppl. 2): 543(Abstract).
    • (2001) Circulation , vol.140 , Issue.SUPPL. 2 , pp. 543
    • Lehman, J.J.1    Weinheiver, C.2    Courtois, M.3    Kovacs, A.4    Kelly, D.P.5
  • 41
    • 0025169628 scopus 로고
    • Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts
    • McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol 1990; 259: H1079-H1085.
    • (1990) Am J Physiol , vol.259
    • McVeigh, J.J.1    Lopaschuk, G.D.2
  • 45
    • 0035976932 scopus 로고    scopus 로고
    • Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart
    • Young ME, Laws FA, Goodwin GW, Taegtmeyer H. Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 2001; 276: 44390-44395.
    • (2001) J Biol Chem , vol.276 , pp. 44390-44395
    • Young, M.E.1    Laws, F.A.2    Goodwin, G.W.3    Taegtmeyer, H.4
  • 46
    • 0028589356 scopus 로고
    • Triacylglycerol turnover in isolated working hearts of acutely diabetic rats
    • Saddik M, Lopaschuk GD. Triacylglycerol turnover in isolated working hearts of acutely diabetic rats. Can J Physiol Pharmocol 1994; 72: 1110-1119.
    • (1994) Can J Physiol Pharmocol , vol.72 , pp. 1110-1119
    • Saddik, M.1    Lopaschuk, G.D.2
  • 47
    • 0033662461 scopus 로고    scopus 로고
    • Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
    • Belke DD, Larsen TS, Gibbs EM, Severson DL. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol 2000; 279: E1104-E1113.
    • (2000) Am J Physiol , vol.279
    • Belke, D.D.1    Larsen, T.S.2    Gibbs, E.M.3    Severson, D.L.4
  • 48
    • 0016251063 scopus 로고
    • Role of diabetes in congestive heart failure: The Framingham Study
    • Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: The Framingham Study. Am J Cardiol 1974; 34: 29-34.
    • (1974) Am J Cardiol , vol.34 , pp. 29-34
    • Kannel, W.B.1    Hjortland, M.2    Castelli, W.P.3
  • 49
    • 0020675541 scopus 로고
    • Congestive heart failure in the diabetic
    • Regan TJ. Congestive heart failure in the diabetic. Ann Rev Med 1983; 34: 161-168.
    • (1983) Ann Rev Med , vol.34 , pp. 161-168
    • Regan, T.J.1
  • 51
    • 0029029643 scopus 로고
    • Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis
    • Corr PB, Yamada KA. Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis. Herz 1995; 20: 156-168.
    • (1995) Herz , vol.20 , pp. 156-168
    • Corr, P.B.1    Yamada, K.A.2
  • 52
    • 0017693366 scopus 로고
    • Accumulation of myocardial triacylglycerols in ketotic diabetes
    • Murthy VK, Shipp JC. Accumulation of myocardial triacylglycerols in ketotic diabetes. Diabetes 1977; 26: 222-229.
    • (1977) Diabetes , vol.26 , pp. 222-229
    • Murthy, V.K.1    Shipp, J.C.2
  • 53
    • 0020146576 scopus 로고
    • Endogenous triacylglycerol metabolism in diabetic heart
    • Paulson DJ, Crass MF. Endogenous triacylglycerol metabolism in diabetic heart. Am J Physiol 1982; 242: 1084-1094.
    • (1982) Am J Physiol , vol.242 , pp. 1084-1094
    • Paulson, D.J.1    Crass, M.F.2
  • 55
    • 0035912954 scopus 로고    scopus 로고
    • Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis
    • Tian R, Abel ED. Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis. Circulation 2001; 103: 2961-2966.
    • (2001) Circulation , vol.103 , pp. 2961-2966
    • Tian, R.1    Abel, E.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.