Hibiscus sabdariffa extract reduces serum cholesterol in men and women

Nutrition Research

Volumn 27, Issue 3, 2007, Pages 140-145

  Lin, Tzu Li ^a   Lin, Hui Hsuan ^a   Chen, Chang Che ^a   Lin, Ming Cheng ^b   Chou, Ming Chih ^b   Wang, Chau Jong ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cholesterol; Cholesterol lowering potential; Hibiscus sabdariffa Linne; Human; Hypercholesterolemia; Medical herb

Indexed keywords

CHOLESTEROL; HIBISCUS SABDARIFFA EXTRACT;

ADULT; AGED; ARTICLE; CARBONATED BEVERAGE; CHEMICAL COMPOSITION; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DRUG ACTIVITY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TAIWAN;

ANIMALIA; HIBISCUS SABDARIFFA; MALVACEAE;

EID: 33947097011     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2007.01.007     Document Type: Article

References (42)

1. Kannel W.B., Castelli W.P., Gordon T., and McNamara P.M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. Ann Intern Med 74 (1971) 1-12
2. Keys A. Coronary heart disease in seven countries. Circulation 41 (1970) 1-211
3. Glade M.J. Food, nutrition, and the prevention of cancer: a global perspective. American Institute of Cancer Research/World Cancer Research Fund. Nutrition 15 (1999) 523-526
4. Klerk M., Jansen M.C., van't Veer P., and Kok F. Fruits and vegetables in chronic disease prevention (1998), Wageningen Agricultural University, Wageningen
5. Steinmetz K.A., and Potter J.D. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96 (1996) 1027-1039
6. Morton L.W., Abu-Amsha C.R., Puddey I.B., and Croft K.D. Chemistry and biological effects of dietary phenolic compounds: relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27 (2000) 152-159
7. Visioli F., Borsani L., and Galli C. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc Res 47 (2000) 419-425
8. Lampe J.W. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70 (1999) 475S-490S
9. Tsuda T., Kato Y., and Osawa T. Mechanism for the peroxynitrite scavenging activity by anthocyanins. FEBS Lett 484 (2000) 207-210
10. Ramirez-Tortosa C., Andersen O.M., Gardner P.T., Morrice P.C., Wood S.G., Duthie S.J., et al. Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic Biol Med 31 (2000) 1033-1037
11. Laura B. Polyphenols: chemistry, dietary sources. Metabolism, and nutritional significance. Nutr Rev 56 (1998) 317-333
12. Tsuda T., Shiga K., Ohshima K., Kawakishi S., and Osawa T. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochem Pharmacol 52 (1996) 1033-1039
13. Haji F.M., and Haji T.A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J Ethnopharmacol 65 (1999) 231-236
14. Onyenekwe P.C., Ajani E.O., Ameh D.A., and Gamaniel K.S. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Funct 17 (1999) 199-206
15. Dafallah A.A., and al-Mustafa Z. Investigation of the anti-inflammatory activity of Acacia nilotica and Hibiscus sabdariffa. Am J Chin Med 24 (1996) 263-269
16. Chewonarin T., Kinouchi T., Kataoka K., Arimochi H., Kuwahara T., Vinitketkumnuen U., et al. Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine in F344 rats. Food Chem Toxicol 37 (1999) 591-601
17. Tseng T.H., Kao E.S., Chu C.Y., Chou F.P., Lin-Wu H.W., and Wang C.J. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol 35 (1997) 1159-1164
18. Wang C.J., Wang J.M., Lin W.L., Chu C.Y., Chou F.P., and Tseng T.H. Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol 38 (2000) 411-416
19. Lee M.J., Chou F.P., Tseng T.H., Hsieh M.H., Lin M.C., and Wang C.J. Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by either copper ion or nitricoxide donor. J Agric Food Chem 50 (2002) 2130-2136
20. Tseng T.H., Kao T.W., Chu C.Y., Chou F.P., Lin W.L., and Wang C.J. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol 60 (2000) 307-315
21. Tseng T.H., Hsu J.D., Lo M.H., Chu C.Y., Chou F.P., Huang C.L., et al. Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett 126 (1998) 199-207
22. Chang Y.C., Huang H.P., Hsu J.D., Yang S.F., and Wang C.J. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol 205 (2005) 201-212
23. Lin H.H., Huang H.P., Huang C.C., Chen J.H., and Wang C.J. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog 43 (2005) 86-99
24. Crawford R.S., Kirk E.A., Rosenfeld M.E., LeBoeuf R.C., and Chait A. Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 18 (1998) 1506-1513
25. Rimm E.B., and Stamfer M.J. Antioxidants for vascular disease. Med Clin North Am 84 (2000) 239-249
26. Tangirala R.K., Casanada F., Miller E., Witztum J.L., Steinberg D., and Palinski W. Effect of the antioxidant N,N′-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice. Arterioscler Thromb Vasc Biol 15 (1995) 1625-1630
27. Chen C.C., Chou F.P., Ho Y.C., Lin W.L., Wang C.P., Hao E.S., et al. Inhibitory effects of Hibiscus sabdarriffa L., extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats. J Sci Food Agric 84 (2004) 1989-1996
28. Chen C.C., Hsu J.D., Wang S.F., Chiang H.C., Yang M.Y., Kao E.S., et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem 51 (2003) 5472-5477
29. Lakenbrink C., Lapczynski S., Maiwald B., and Engelhardt U.H. Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages. J Agric Food Chem 48 (2000) 2848-2852
30. Fuleki T., and Francis F.J. Quantitative method for anthocyanins. II. Determination of total anthocyanins and degradative index for cranberry juice. J Food Sci 33 (1969) 78-83
31. Jia Z., Tang M., and Wu J. The determination of flavonoid contents in mulberry and their scavenging effects on superoxides radicals. Food Chem 64 (1998) 555-559
32. Chen S.T., Ferng S.H., Yang C.S., Peng S.J., Lee H.R., and Chen J.R. Variable effects of soy protein on plasma lipids in hyperlipidemic and normolipidemic hemodialysis patients. Am J Kidney Dis 46 (2005) 1099-1106
33. Christenson J., Etherington J., Grafstein E., Innes G., Pennington S., Wanger K., et al. Early discharge of patients with presumed opioid overdose: development of a clinical prediction rule. Acad Emerg Med 7 (2000) 1110-1118
34. Liu J.Y., Chen C.C., Wang W.H., Hsu J.D., Yang M.Y., and Wang C.J. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol 44 (2006) 336-343
35. Amin A., and Hamza A.A. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci 77 (2005) 266-278
36. Pichardo R., Boulet L., and Davignon J. Pharmacokinetics of clofibrate in familial hypercholesterolemia. Atherosclerosis 26 (1977) 573-582
37. Degenring F.H., Schatton W., and Hotz W. Atherosclerosis treatment with etofibrate retard. New perspectives. Fortschr Med 101 (1983) 1391-1396
38. Kruger B. Etofibrate therapy and effect of added low-dose cholestyramine in patients with combined hyperlipidaemia. Int J Clin Pharmacol Res 14 (1994) 177-183
39. Frick M.H., Elo O., Haapa K., Heinonen O.P., Heinsalmi P., Helo P., et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 317 (1987) 1237-1245
40. Scott R. Lipid modifying agents: mechanisms of action and reduction of cardiovascular disease. Clin Exp Pharmacol Physiol 24 (1997) A26-A28
41. Carvajal-Zarrabal O., Waliszewski S.M., Barradas-Dermitz D.M., Orta-Flores Z., Hayward-Jones P.M., Nolasco-Hipolito C., et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Foods Hum Nutr 60 (2005) 153-159
42. Hirunpanich V., Utaipat A., Morales N.P., Bunyapraphatsara N., Sato H., Herunsale A., et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol 103 (2006) 252-260