Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1555-1558

  Zhou, Lin ^a   Alker, André ^b   Ruf, Armin ^b   Wang, Xiaofang ^a   Chiu, Francis C K ^c   Morizzi, Julia ^c   Charman, Susan A ^c   Charman, William N ^c   Scheurer, Christian ^d   Wittlin, Sergio ^d   Dong, Yuxiang ^a   Hunziker, Daniel ^b   Vennerstrom, Jonathan L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c MONASH UNIVERSITY   (Australia)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

1,2,4 Trioxolane; Antimalarial; CYP450; Ozonide; Synthetic peroxide

Indexed keywords

ANTIMALARIAL AGENT; CARBON; CYTOCHROME P450; DRUG METABOLITE; METHANOL; OZ 277; OZ 381; OZ 397; OZONIDE(1,2,4 TRIOXOLANE); UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; LIVER MICROSOME;

EID: 39849090620     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.087     Document Type: Article

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