Antimalarial activity of the bisquinoline trans-N1,N2-bis (7- chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 3, 1997, Pages 677-686

  Ridley, Robert G ^a   Matile, Hugues ^a   Jaquet, Catherine ^a   Dorn, Arnulf ^a   Hofheinz, Werner ^a   Leupin, Werner ^a   Masciadri, Raffaello ^a   Theil, Frank Peter ^a   Richter, Wolfgang F ^a   Girometta, Maria Angela ^a   Guenzi, Alberto ^a   Urwyler, Heinrich ^a   Gocke, Elmar ^a   Potthast, Jörg Michael ^a   Csato, Miklos ^a   Thomas, Alan ^b   Peters, Wallace ^c  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b TNO   (Netherlands)

^c CABI   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; MEFLOQUINE; N,N BIS(7 CHLOROQUINOLIN 4 YL)CYCLOHEXANE 1,2 DIAMINE; N1,N2 BIS(7 CHLORO 4 QUINOLINYL) 1,2 CYCLOHEXANEDIAMINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; WR 268668;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; ENANTIOMER; MALARIA; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031018611     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.3.677     Document Type: Article

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