-
1
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Demonstrates the role of autophagy in Paneth cells, relating to Crohn's disease
-
Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-263. Demonstrates the role of autophagy in Paneth cells, relating to Crohn's disease.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
-
2
-
-
37549043217
-
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
-
Sanjuan MA, Dillon CP, Tait SW, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007; 450:1253-1257.
-
(2007)
Nature
, vol.450
, pp. 1253-1257
-
-
Sanjuan, M.A.1
Dillon, C.P.2
Tait, S.W.3
-
3
-
-
34548482499
-
SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
-
Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282:25464-25474.
-
(2007)
J Biol Chem
, vol.282
, pp. 25464-25474
-
-
Chan, E.Y.1
Kir, S.2
Tooze, S.A.3
-
4
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
5
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
This study demonstrates that mTORC1 suppresses autophagy by interacting directly with the ULK1-Atg13-FIP200 complex
-
Hosokawa N, Hara T, Kaizuka T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981-1991. This study demonstrates that mTORC1 suppresses autophagy by interacting directly with the ULK1-Atg13-FIP200 complex.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
-
6
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
-
7
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Identifies the mammalian orthologue of yeast ATG14 and defines the important role of the Atg14-Beclin 1-hVPS34 complex in the initiation of autophagy
-
Itakura E, Kishi C, Inoue K, et al. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19:5360-5372. Identifies the mammalian orthologue of yeast ATG14 and defines the important role of the Atg14-Beclin 1-hVPS34 complex in the initiation of autophagy.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
-
8
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009; 11:385-396.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
Saitoh, T.2
Tabata, K.3
-
9
-
-
57749100267
-
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
-
Shi CS, Kehrl JH. MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem 2008; 283:33175-33182.
-
(2008)
J Biol Chem
, vol.283
, pp. 33175-33182
-
-
Shi, C.S.1
Kehrl, J.H.2
-
10
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688-699.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 688-699
-
-
Liang, C.1
Feng, P.2
Ku, B.3
-
11
-
-
34347344990
-
Ambra1 regulates autophagy and development of the nervous system
-
Fimia GM, Stoykova A, Romagnoli A, et al. Ambra1 regulates autophagy and development of the nervous system. Nature 2007; 447:1121-1125.
-
(2007)
Nature
, vol.447
, pp. 1121-1125
-
-
Fimia, G.M.1
Stoykova, A.2
Romagnoli, A.3
-
12
-
-
46449120732
-
Beclin1-binding UVRAG targets the class CVps complex to coordinate autophagosome maturation and endocytic trafficking
-
Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class CVps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 2008; 10:776-787.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 776-787
-
-
Liang, C.1
Lee, J.S.2
Inn, K.S.3
-
13
-
-
64049113909
-
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
-
Using mouse genetics and biochemistry, the group identifies the mammalian orthologue of yeast Atg14. The authors go on to show its involvement with Beclin 1 and a novel protein Rubicon and suggest novel roles for these complexes in regulating autophagy at multiple stages
-
Zhong Y, Wang QJ, Li X, et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009; 11:468-476. Using mouse genetics and biochemistry, the group identifies the mammalian orthologue of yeast Atg14. The authors go on to show its involvement with Beclin 1 and a novel protein Rubicon and suggest novel roles for these complexes in regulating autophagy at multiple stages.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 468-476
-
-
Zhong, Y.1
Wang, Q.J.2
Li, X.3
-
14
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
-
15
-
-
28844502647
-
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy
-
Sugawara K, Suzuki NN, Fujioka Y, et al. Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem 2005; 280:40058-40065.
-
(2005)
J Biol Chem
, vol.280
, pp. 40058-40065
-
-
Sugawara, K.1
Suzuki, N.N.2
Fujioka, Y.3
-
16
-
-
65649136884
-
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
-
Satoo K, Noda NN, Kumeta H, et al. The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009; 28:1341-1350.
-
(2009)
EMBO J
, vol.28
, pp. 1341-1350
-
-
Satoo, K.1
Noda, N.N.2
Kumeta, H.3
-
17
-
-
0347695019
-
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
-
Hemelaar J, Lelyveld VS, Kessler BM, et al. A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem 2003; 278:51841-51850.
-
(2003)
J Biol Chem
, vol.278
, pp. 51841-51850
-
-
Hemelaar, J.1
Lelyveld, V.S.2
Kessler, B.M.3
-
18
-
-
3242888703
-
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
-
Kabeya Y, Mizushima N, Yamamoto A, et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004; 117:2805-2812.
-
(2004)
J Cell Sci
, vol.117
, pp. 2805-2812
-
-
Kabeya, Y.1
Mizushima, N.2
Yamamoto, A.3
-
19
-
-
65249185812
-
A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy
-
Huett A, Ng A, Cao Z, et al. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. J Immunol 2009; 182:4917-4930.
-
(2009)
J Immunol
, vol.182
, pp. 4917-4930
-
-
Huett, A.1
Ng, A.2
Cao, Z.3
-
20
-
-
67549132527
-
The late stages of autophagy: How does the end begin?
-
Noda T, Fujita N, Yoshimori T. The late stages of autophagy: how does the end begin? Cell Death Differ 2009; 16:984-990.
-
(2009)
Cell Death Differ
, vol.16
, pp. 984-990
-
-
Noda, T.1
Fujita, N.2
Yoshimori, T.3
-
21
-
-
58149290220
-
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
-
Fujita N, Hayashi-Nishino M, Fukumoto H, et al. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell 2008; 19:4651-4659.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4651-4659
-
-
Fujita, N.1
Hayashi-Nishino, M.2
Fukumoto, H.3
-
22
-
-
47149089713
-
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes
-
Kimura S, Noda T, Yoshimori T. Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct 2008; 33:109-122.
-
(2008)
Cell Struct Funct
, vol.33
, pp. 109-122
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
23
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
Gutierrez MG, Master SS, Singh SB, et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753-766.
-
(2004)
Cell
, vol.119
, pp. 753-766
-
-
Gutierrez, M.G.1
Master, S.S.2
Singh, S.B.3
-
24
-
-
47849094901
-
Autophagic control of listeria through intracellular innate immune recognition in drosophila
-
First in-vivo demonstration of autophagy acting as an innate defence mechanism against bacterial infection
-
Yano T, Mita S, Ohmori H, et al. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol 2008; 9:908-916. First in-vivo demonstration of autophagy acting as an innate defence mechanism against bacterial infection.
-
(2008)
Nat Immunol
, vol.9
, pp. 908-916
-
-
Yano, T.1
Mita, S.2
Ohmori, H.3
-
25
-
-
1042290507
-
Antimicrobial polypeptides of the human colonic epithelium
-
Howell SJ, Wilk D, Yadav SP, et al. Antimicrobial polypeptides of the human colonic epithelium. Peptides 2003; 24:1763-1770.
-
(2003)
Peptides
, vol.24
, pp. 1763-1770
-
-
Howell, S.J.1
Wilk, D.2
Yadav, S.P.3
-
26
-
-
41949101594
-
Toll-like receptors control autophagy
-
A TLR agonist screen is used to demonstrate that multiple TLR agonists can induce autophagy
-
Delgado MA, Elmaoued RA, Davis AS, et al. Toll-like receptors control autophagy. EMBO J 2008; 27:1110-1121. A TLR agonist screen is used to demonstrate that multiple TLR agonists can induce autophagy.
-
(2008)
EMBO J
, vol.27
, pp. 1110-1121
-
-
Delgado, M.A.1
Elmaoued, R.A.2
Davis, A.S.3
-
27
-
-
58049204465
-
Autophagy and pattern recognition receptors in innate immunity
-
Delgado M, Singh S, De Haro S, et al. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev 2009; 227:189-202.
-
(2009)
Immunol Rev
, vol.227
, pp. 189-202
-
-
Delgado, M.1
Singh, S.2
De Haro, S.3
-
28
-
-
20044379559
-
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signalling
-
Foy E, Li K, Sumpter RJ, et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signalling. Proc Natl Acad Sci U S A 2005; 102:2986-2991.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2986-2991
-
-
Foy, E.1
Li, K.2
Sumpter, R.J.3
-
29
-
-
26244438381
-
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium
-
Lee S, Comer FI, Sasaki A, et al. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 2005; 16:4572-4583.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4572-4583
-
-
Lee, S.1
Comer, F.I.2
Sasaki, A.3
-
30
-
-
62449110463
-
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signalling
-
Demonstrates that autophagy is involved in the homeostatic regulation of innate antiviral defence via the clearance of dysfunctional mitochondria. Also demonstrates that mitochondrial associated ROS play a role in RLR signalling
-
Tal MC, Sasai M, Lee HK, et al. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signalling. Proc Natl Acad Sci U S A 2009; 106:2770-2775. Demonstrates that autophagy is involved in the homeostatic regulation of innate antiviral defence via the clearance of dysfunctional mitochondria. Also demonstrates that mitochondrial associated ROS play a role in RLR signalling.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2770-2775
-
-
Tal, M.C.1
Sasai, M.2
Lee, H.K.3
-
31
-
-
34548434775
-
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
-
Suzuki T, Franchi L, Toma C, et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 2007; 3:e111.
-
(2007)
PLoS Pathog
, vol.3
-
-
Suzuki, T.1
Franchi, L.2
Toma, C.3
-
32
-
-
41849104578
-
Mycobacterium tuberculosis prevents inflammasome activation
-
Master SS, Rampini SK, Davis AS, et al. Mycobacterium tuberculosis prevents inflammasome activation. Cell Host Microbe 2008; 3:224-232.
-
(2008)
Cell Host Microbe
, vol.3
, pp. 224-232
-
-
Master, S.S.1
Rampini, S.K.2
Davis, A.S.3
-
33
-
-
33846014297
-
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and doublestranded RNA
-
Kanneganti TD, Body-Malapel M, Amer A, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and doublestranded RNA. J Biol Chem 2006; 281:36560-36568.
-
(2006)
J Biol Chem
, vol.281
, pp. 36560-36568
-
-
Kanneganti, T.D.1
Body-Malapel, M.2
Amer, A.3
-
34
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve DA, Petrilli V, Zaiss AK, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008; 452:103-107.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
Petrilli, V.2
Zaiss, A.K.3
-
35
-
-
58149159542
-
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
-
Villani AC, Lemire M, Fortin G, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009; 41:71-76.
-
(2009)
Nat Genet
, vol.41
, pp. 71-76
-
-
Villani, A.C.1
Lemire, M.2
Fortin, G.3
-
36
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhancesendotoxin-inducedIL- 1betaproduction
-
Using transgenic ATG16L1 knockout mice demonstrate the role autophagy plays in IBD
-
Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhancesendotoxin-inducedIL-1betaproduction.Nature2008;456:264-268. Using transgenic ATG16L1 knockout mice demonstrate the role autophagy plays in IBD.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
-
37
-
-
52149099867
-
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
-
A critical study which demonstrates that autophagy and MHC-restricted endogenous antigen presentation by thymic epithelial cells is important in tolerance
-
Nedjic J, Aichinger M, Emmerich J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008; 455:396-400. A critical study which demonstrates that autophagy and MHC-restricted endogenous antigen presentation by thymic epithelial cells is important in tolerance.
-
(2008)
Nature
, vol.455
, pp. 396-400
-
-
Nedjic, J.1
Aichinger, M.2
Emmerich, J.3
-
38
-
-
0034671603
-
Autophagosome-associated variant isoforms of cytosolic enzymes
-
Fengsrud M, Raiborg C, Berg TO, et al. Autophagosome-associated variant isoforms of cytosolic enzymes. Biochem J 2000; 352:773-781.
-
(2000)
Biochem J
, vol.352
, pp. 773-781
-
-
Fengsrud, M.1
Raiborg, C.2
Berg, T.O.3
-
39
-
-
33846224369
-
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
-
Demonstrates the role of autophagy in delivering cytosolic agents to endosomally located MHC II
-
Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007; 26:79-92. Demonstrates the role of autophagy in delivering cytosolic agents to endosomally located MHC II.
-
(2007)
Immunity
, vol.26
, pp. 79-92
-
-
Schmid, D.1
Pypaert, M.2
Munz, C.3
-
40
-
-
62049084947
-
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
-
Jagannath C, Lindsey DR, Dhandayuthapani S, et al. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med 2009; 15:267-276.
-
(2009)
Nat Med
, vol.15
, pp. 267-276
-
-
Jagannath, C.1
Lindsey, D.R.2
Dhandayuthapani, S.3
-
41
-
-
33846461678
-
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
-
Pua HH, Dzhagalov I, Chuck M, et al. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204:25-31.
-
(2007)
J Exp Med
, vol.204
, pp. 25-31
-
-
Pua, H.H.1
Dzhagalov, I.2
Chuck, M.3
-
42
-
-
67650216238
-
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
-
Stephenson LM, Miller BC, Ng A, et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009; 5:625-635.
-
(2009)
Autophagy
, vol.5
, pp. 625-635
-
-
Stephenson, L.M.1
Miller, B.C.2
Ng, A.3
-
43
-
-
41449106674
-
The autophagy gene ATG5 plays an essential role in B lymphocyte development
-
Using a murine Atg5 deletion specific to B cells, demonstrates the role of autophagy in B cell development and homeostasis
-
Miller BC, Zhao Z, Stephenson LM, et al. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008; 4:309-314. Using a murine Atg5 deletion specific to B cells, demonstrates the role of autophagy in B cell development and homeostasis.
-
(2008)
Autophagy
, vol.4
, pp. 309-314
-
-
Miller, B.C.1
Zhao, Z.2
Stephenson, L.M.3
-
44
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007; 39:596-604.
-
(2007)
Nat Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
Xavier, R.J.2
Taylor, K.D.3
-
45
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-962.
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
-
46
-
-
50449091647
-
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
-
Demonstrates that the IRGM noncoding polymorphism associated with Crohn's disease is associated with a large deletion haplotype
-
McCarroll SA, Huett A, Kuballa P, et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008; 40:1107-1112. Demonstrates that the IRGM noncoding polymorphism associated with Crohn's disease is associated with a large deletion haplotype.
-
(2008)
Nat Genet
, vol.40
, pp. 1107-1112
-
-
McCarroll, S.A.1
Huett, A.2
Kuballa, P.3
-
47
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh SB, Davis AS, Taylor GA, et al. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313:1438-1441.
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
-
48
-
-
54849421128
-
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
-
Demonstrates that the ATG16L1 T300A CD risk-associated variant is destabilized upon infection with, and cannot support autophagic clearance of, S. typhimurium, using an in-vitro cell culture model
-
Kuballa P, Huett A, Rioux JD, et al. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 2008; 3:e3391. Demonstrates that the ATG16L1 T300A CD risk-associated variant is destabilized upon infection with, and cannot support autophagic clearance of, S. typhimurium, using an in-vitro cell culture model.
-
(2008)
PLoS ONE
, vol.3
-
-
Kuballa, P.1
Huett, A.2
Rioux, J.D.3
-
49
-
-
38449116497
-
Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)
-
Henry SC, Daniell X, Indaram M, et al. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J Immunol 2007; 179:6963-6972.
-
(2007)
J Immunol
, vol.179
, pp. 6963-6972
-
-
Henry, S.C.1
Daniell, X.2
Indaram, M.3
-
50
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007; 39:830-832.
-
(2007)
Nat Genet
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
-
52
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Demonstrates the important role of autophagy in the regulation of p62 and tumour suppression
-
Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137:1062-1075. Demonstrates the important role of autophagy in the regulation of p62 and tumour suppression.
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
-
53
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J, Shao SH, Xu ZX, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218-224.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
-
54
-
-
48249125798
-
Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation
-
Ueno T, Sato W, Horie Y, et al. Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation. Autophagy 2008; 4:692-700.
-
(2008)
Autophagy
, vol.4
, pp. 692-700
-
-
Ueno, T.1
Sato, W.2
Horie, Y.3
-
55
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D, Wilkinson S, O'Prey J, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126:121-134.
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'prey, J.3
-
56
-
-
66449115318
-
Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells
-
Salazar M, Carracedo A, Salanueva IJ, et al. Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009; 119:1359-1372.
-
(2009)
J Clin Invest
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
-
57
-
-
67549084381
-
Superoxide is the major reactive oxygen species regulating autophagy
-
Demonstrates that superoxide is the main ROS regulator of autophagy and highlights the important point that not all ROS contribute equally to autophagy
-
Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ 2009; 16:1040-1052. Demonstrates that superoxide is the main ROS regulator of autophagy and highlights the important point that not all ROS contribute equally to autophagy.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1040-1052
-
-
Chen, Y.1
Azad, M.B.2
Gibson, S.B.3
-
58
-
-
61449117883
-
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death
-
Zhao YO, Khaminets A, Hunn JP, et al. Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog 2009; 5:e1000288.
-
(2009)
PLoS Pathog
, vol.5
-
-
Zhao, Y.O.1
Khaminets, A.2
Hunn, J.P.3
-
59
-
-
55949125413
-
Membrane proteomics of phagosomes suggests a connection to autophagy
-
Shui W, Sheu L, Liu J, et al. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A 2008; 105:16952-16957.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16952-16957
-
-
Shui, W.1
Sheu, L.2
Liu, J.3
|