메뉴 건너뛰기




Volumn 9, Issue 14, 2009, Pages 1317-1334

Neuron protection as a therapeutic target in acute ischemic stroke

Author keywords

[No Author keywords available]

Indexed keywords

3K3A ACTIVATED PROTEIN C; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR ANTAGONIST; BACLOFEN; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BLOOD CLOTTING FACTOR; BW 619C87; CALCIUM CHANNEL BLOCKING AGENT; CITICOLINE; DISUFENTON SODIUM; DIZOCILPINE; DROTRECOGIN; KAINIC ACID RECEPTOR ANTAGONIST; KYNURENIC ACID; KYNURENINE; LANICEMINE; LY 393615; MEMANTINE; MUSCIMOL; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NICARDIPINE; NIMODIPINE; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; SB 201823A; SB 221420A; SIPATRIGINE; SODIUM CHANNEL BLOCKING AGENT; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 74249111108     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802609789869646     Document Type: Review
Times cited : (98)

References (78)
  • 1
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • National Institute of Neurological Disorders, Stroke rt-PA Stroke Study Group
    • National Institute of Neurological Disorders, Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333(24), 1581-7.
    • (1995) N Engl J Med , vol.333 , Issue.24 , pp. 1581-1587
  • 2
    • 9744226432 scopus 로고    scopus 로고
    • Protecting the brain, the search for a clinically effective neuroprotective drug for stroke
    • Green, A.R. Protecting the brain, the search for a clinically effective neuroprotective drug for stroke. Crit Rev Neurobiol. 2004; 16(1-2), 91-7.
    • (2004) Crit Rev Neurobiol , vol.16 , Issue.1-2 , pp. 91-97
    • Green, A.R.1
  • 3
    • 0025165826 scopus 로고
    • Background review and current concepts of reperfusion injury
    • Hallenbeck, J.M.; Dutka, A.J. Background review and current concepts of reperfusion injury. Arch Neurol. 1990; 47(11), 1245-54.
    • (1990) Arch Neurol , vol.47 , Issue.11 , pp. 1245-1254
    • Hallenbeck, J.M.1    Dutka, A.J.2
  • 4
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo, E.H.; Dalkara, T.; Moskowitz, M.A. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003; 4, 399-415.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 5
    • 0037319335 scopus 로고    scopus 로고
    • Emerging therapies for acute ischemic stroke, new therapies on trial
    • Fisher, M.; Brott, T.G. Emerging therapies for acute ischemic stroke, new therapies on trial. Stroke. 2003; 34, 359-61.
    • (2003) Stroke , vol.34 , pp. 359-361
    • Fisher, M.1    Brott, T.G.2
  • 6
    • 17344384728 scopus 로고    scopus 로고
    • Molecular pathways in cerebral ischemia, cues to novel therapeutic strategies
    • Onteniente, B.; Rasika, S.; Benchoua, A.; Guegan, C. Molecular pathways in cerebral ischemia, cues to novel therapeutic strategies. Mol Neurobiol 2003; 27, 33-72.
    • (2003) Mol Neurobiol , vol.27 , pp. 33-72
    • Onteniente, B.1    Rasika, S.2    Benchoua, A.3    Guegan, C.4
  • 8
    • 30744466144 scopus 로고    scopus 로고
    • Perinatal seizures preferentially protect CA1 neurons from seizure-induced damage in prepubescent rats
    • Liu, H.; Friedman, L.K.; and Kaur, J. Perinatal seizures preferentially protect CA1 neurons from seizure-induced damage in prepubescent rats. Seizure. 2006; 15, 1-16.
    • (2006) Seizure , vol.15 , pp. 1-16
    • Liu, H.1    Friedman, L.K.2    Kaur, J.3
  • 9
    • 0026590602 scopus 로고
    • Convulsive seizures in rats induced by Nmethyl- D-aspartate injection into the massa intermedia
    • Hirayasu, Y. and Wada, J.A. Convulsive seizures in rats induced by Nmethyl- D-aspartate injection into the massa intermedia. Brain Res. 1992; 577, 36-40
    • (1992) Brain Res , vol.577 , pp. 36-40
    • Hirayasu, Y.1    Wada, J.A.2
  • 10
    • 0026526908 scopus 로고
    • Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice
    • Mathis, C. and Ungerer, A. Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice. Exp. Brain Res. 1992; 88, 277-282.
    • (1992) Exp. Brain Res , vol.88 , pp. 277-282
    • Mathis, C.1    Ungerer, A.2
  • 11
    • 0026661039 scopus 로고
    • The paradoxical effect of NMDA receptor stimulation on electrical activity of the sensorimotor cortex in freely behaving rats, Analysis by combined EEG-intracerebral microdialysis
    • Ludvig, N.; Mishra, P.K.; Yan, Q.S.; Lasley, S.M.; Burger, R.L.; and Jobe, P.C. The paradoxical effect of NMDA receptor stimulation on electrical activity of the sensorimotor cortex in freely behaving rats, Analysis by combined EEG-intracerebral microdialysis. Synapse. 1992; 12, 87-98
    • (1992) Synapse , vol.12 , pp. 87-98
    • Ludvig, N.1    Mishra, P.K.2    Yan, Q.S.3    Lasley, S.M.4    Burger, R.L.5    Jobe, P.C.6
  • 12
    • 0027462610 scopus 로고
    • Central anticonvulsant effects of magnesium sulfate on N-methyl-D- aspartate- induced seizures
    • Cotton, D.B.; Hallak, M.; Janusz, C.; Irtenkauf, S.M.; Berman, R.F. Central anticonvulsant effects of magnesium sulfate on N-methyl-D- aspartate- induced seizures. Am. J. Obstet. Gynecol. 1993; 168, 974-978.
    • (1993) Am. J. Obstet. Gynecol , vol.168 , pp. 974-978
    • Cotton, D.B.1    Hallak, M.2    Janusz, C.3    Irtenkauf, S.M.4    Berman, R.F.5
  • 13
    • 0027381854 scopus 로고
    • Stimulation and inhibition of N-methyl-D-aspartate receptors in rats, Developing a seizure model
    • Hallak, M.; Irtenkauf, S.M.; Janusz, C.A.; and Cotton, D.B. Stimulation and inhibition of N-methyl-D-aspartate receptors in rats, Developing a seizure model. Am. J. Obstet. Gynecol. 1993 3, 695-700.
    • (1993) Am. J. Obstet. Gynecol , vol.3 , pp. 695-700
    • Hallak, M.1    Irtenkauf, S.M.2    Janusz, C.A.3    Cotton, D.B.4
  • 14
    • 0030842209 scopus 로고    scopus 로고
    • Effects of acute and repeated administration of N-methyl-D-aspartate (NMDA) into the ventral tegmental, Locomotor activating effects of NMDA and cocaine
    • Schenk, S. and Partridge, B. Effects of acute and repeated administration of N-methyl-D-aspartate (NMDA) into the ventral tegmental, Locomotor activating effects of NMDA and cocaine. Brain Res. 1997; 769, 225-232.
    • (1997) Brain Res , vol.769 , pp. 225-232
    • Schenk, S.1    Partridge, B.2
  • 15
    • 0033973982 scopus 로고    scopus 로고
    • Cellular electrophysiological changes in the hippocampus of freely behaving rats during local microdialysis with epileptogenic concentration of N-methyl-D-aspartate
    • Ludvig, N. and Tang, H.M. Cellular electrophysiological changes in the hippocampus of freely behaving rats during local microdialysis with epileptogenic concentration of N-methyl-D-aspartate. Brain Res. Bulletin 2000; 51, 233-240
    • (2000) Brain Res. Bulletin , vol.51 , pp. 233-240
    • Ludvig, N.1    Tang, H.M.2
  • 16
    • 0031719095 scopus 로고    scopus 로고
    • Postischemic enhancements of N-methyl-D-aspartic acid (NMDA) and non-NMDA receptor-mediated responses in hippocampal CA1 pyramidal neurons
    • Mitani, A.; Namba, S.; Ikemune, K.; Yanase, H.; Arai, T.; and Kataoka,K. Postischemic enhancements of N-methyl-D-aspartic acid (NMDA) and non-NMDA receptor-mediated responses in hippocampal CA1 pyramidal neurons. J. Cereb. Blood Flow Metab. 1998; 10, 1088-1098.
    • (1998) J. Cereb. Blood Flow Metab , vol.10 , pp. 1088-1098
    • Mitani, A.1    Namba, S.2    Ikemune, K.3    Yanase, H.4    Arai, T.5    Kataoka, K.6
  • 18
    • 0034938584 scopus 로고    scopus 로고
    • Neuronal protein kinase signaling cascades and excitotoxic cell death
    • Jun;
    • Skaper, S.D.; Facci, L.; Strijbos, P.J. Neuronal protein kinase signaling cascades and excitotoxic cell death. Ann N Y Acad Sci. 2001; Jun; 939, 11-22.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 11-22
    • Skaper, S.D.1    Facci, L.2    Strijbos, P.J.3
  • 19
    • 0141615744 scopus 로고    scopus 로고
    • Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke
    • Oct;
    • Dambinova, S.A.; Khounteev, G.A.; Izykenova, G.A.; Zavolokov, I.G.; Ilyukhina, A.Y.; Skoromets, A.A. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem. 2003; Oct; 49(10), 1752-62.
    • (2003) Clin Chem , vol.49 , Issue.10 , pp. 1752-1762
    • Dambinova, S.A.1    Khounteev, G.A.2    Izykenova, G.A.3    Zavolokov, I.G.4    Ilyukhina, A.Y.5    Skoromets, A.A.6
  • 20
    • 34250625265 scopus 로고    scopus 로고
    • Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils
    • Jun 14;
    • Gigler, G.; Szénási, G.; Simó, A.; Lévay, G.; Hársing, L.G. Jr, Sas, K.; Vécsei, L.; Toldi, J. Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils. Eur J Pharmacol. 2007; Jun 14; 564(1-3), 116-22.
    • (2007) Eur J Pharmacol , vol.564 , Issue.1-3 , pp. 116-122
    • Gigler, G.1    Szénási, G.2    Simó, A.3    Lévay, G.4    Hársing Jr, L.G.5    Sas, K.6    Vécsei, L.7    Toldi, J.8
  • 21
    • 62549112730 scopus 로고    scopus 로고
    • Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation
    • Dec;
    • Ahmad, A.S.; Yun, Y.T.; Ahmad, M.; Maruyama, T.; Doré, S. Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation. Neurotox Res. 2008; Dec; 14(4), 343-51.
    • (2008) Neurotox Res , vol.14 , Issue.4 , pp. 343-351
    • Ahmad, A.S.1    Yun, Y.T.2    Ahmad, M.3    Maruyama, T.4    Doré, S.5
  • 23
    • 36348984521 scopus 로고    scopus 로고
    • Vandresen-Filho, S.; de Araújo, Herculano, B.; Franco, J.L.; Boeck, C.R.; Dafre, A.L.; Tasca, C.I. Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus. Brain Res. 2007; Dec 12; 1184, 38-45.
    • Vandresen-Filho, S.; de Araújo, Herculano, B.; Franco, J.L.; Boeck, C.R.; Dafre, A.L.; Tasca, C.I. Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus. Brain Res. 2007; Dec 12; 1184, 38-45.
  • 24
    • 34447527799 scopus 로고    scopus 로고
    • Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation
    • Xu, J.; Zhang, Q.G.; Li, C.; Zhang, G.Y. Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Hippocampus. 2007; 17(7), 525-37.
    • (2007) Hippocampus , vol.17 , Issue.7 , pp. 525-537
    • Xu, J.1    Zhang, Q.G.2    Li, C.3    Zhang, G.Y.4
  • 25
    • 0035134256 scopus 로고    scopus 로고
    • Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients, a dose-ranging study
    • Lees, K.R.; Dyker, A.G.; Sharma, A.; Ford, G.A.; Ardron, M.E.; Grosset, D.G. Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients, a dose-ranging study. Stroke 2001; 32, 466-472.
    • (2001) Stroke , vol.32 , pp. 466-472
    • Lees, K.R.1    Dyker, A.G.2    Sharma, A.3    Ford, G.A.4    Ardron, M.E.5    Grosset, D.G.6
  • 26
    • 0036249910 scopus 로고    scopus 로고
    • Treatment of acute ischaemic stroke with the lowaffinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study
    • Diener, H.C.; AlKhedr, A.; Busse, O.; Hacke, W.; Zingmark, P.H.; Jonsson, N. et al. . Treatment of acute ischaemic stroke with the lowaffinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study. J Neurol 2002; 249, 561-568.
    • (2002) J Neurol , vol.249 , pp. 561-568
    • Diener, H.C.1    AlKhedr, A.2    Busse, O.3    Hacke, W.4    Zingmark, P.H.5    Jonsson, N.6
  • 27
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir, K.W.; Lees, K.R. (1995). Clinical experience with excitatory amino acid antagonist drugs. Stroke 1995; 26, 503-513.
    • (1995) Stroke , vol.1995 , Issue.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 28
    • 0035134256 scopus 로고    scopus 로고
    • Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients, a dose-ranging study. Lees, K.R.; Dyker, A.G.; Sharma, A.; Ford, G.A.; Ardron, M.E.; Grosset, D.G. Stroke. 2001; Feb; 32(2), 466-72.
    • Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients, a dose-ranging study. Lees, K.R.; Dyker, A.G.; Sharma, A.; Ford, G.A.; Ardron, M.E.; Grosset, D.G. Stroke. 2001; Feb; 32(2), 466-72.
  • 29
    • 0036249910 scopus 로고    scopus 로고
    • Study group. Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist ARR15896AR. A safety and tolerability study
    • May;
    • Diener, H.C.; AlKhedr, A.; Busse, O.; Hacke, W.; Zingmark, P.H.; Jonsson, N.; Basun, H. Study group. Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist ARR15896AR. A safety and tolerability study. J Neurol. 2002; May; 249(5), 561-8
    • (2002) J Neurol , vol.249 , Issue.5 , pp. 561-568
    • Diener, H.C.1    AlKhedr, A.2    Busse, O.3    Hacke, W.4    Zingmark, P.H.5    Jonsson, N.6    Basun, H.7
  • 30
    • 0042919342 scopus 로고    scopus 로고
    • Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion
    • Sep;
    • Marshall, J.W.; Cummings, R.M.; Bowes, L.J.; Ridley, R.M.; Green, A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion. Stroke. 2003; Sep; 34(9), 2228-33.
    • (2003) Stroke , vol.34 , Issue.9 , pp. 2228-2233
    • Marshall, J.W.1    Cummings, R.M.2    Bowes, L.J.3    Ridley, R.M.4    Green, A.R.5
  • 32
    • 1842535186 scopus 로고    scopus 로고
    • Molecular mechanisms underlying specificity of excitotoxic signaling in neurons
    • Mar;
    • Aarts, M.M.; Tymianski, M. Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med. 2004; Mar; 4(2), 137-47.
    • (2004) Curr Mol Med , vol.4 , Issue.2 , pp. 137-147
    • Aarts, M.M.1    Tymianski, M.2
  • 33
    • 0028217064 scopus 로고
    • Stimulus-transcription coupling in focal cerebral ischemia
    • Jan;
    • Kiessling, M.; Gass, P. Stimulus-transcription coupling in focal cerebral ischemia. Brain Pathol. 1994; Jan; 4(1), 77-83.
    • (1994) Brain Pathol , vol.4 , Issue.1 , pp. 77-83
    • Kiessling, M.1    Gass, P.2
  • 34
    • 0032804101 scopus 로고    scopus 로고
    • Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia
    • Friedman, L.K.; Belayev, L.; Alfonso, O.F.; Ginsberg, M.D. Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia. Neuroscience. 2000; 95(3), 841-57.
    • (2000) Neuroscience , vol.95 , Issue.3 , pp. 841-857
    • Friedman, L.K.1    Belayev, L.2    Alfonso, O.F.3    Ginsberg, M.D.4
  • 35
    • 47549109018 scopus 로고    scopus 로고
    • Glutamate preconditioning prevents neuronal death induced by combined oxygen-glucose deprivation in cultured cortical neurons
    • Jul 28;
    • Lin, C.H.; Chen, P.S.; Gean, P.W. Glutamate preconditioning prevents neuronal death induced by combined oxygen-glucose deprivation in cultured cortical neurons. Eur J Pharmacol. 2008; Jul 28; 589(1-3), 85-93.
    • (2008) Eur J Pharmacol , vol.589 , Issue.1-3 , pp. 85-93
    • Lin, C.H.1    Chen, P.S.2    Gean, P.W.3
  • 36
    • 37349030194 scopus 로고    scopus 로고
    • Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter
    • Jan 15;
    • Bakiri, Y.; Hamilton, N.B.; Káradóttir, R.; Attwell, D. Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia. 2008; Jan 15; 56(2), 233-40.
    • (2008) Glia , vol.56 , Issue.2 , pp. 233-240
    • Bakiri, Y.1    Hamilton, N.B.2    Káradóttir, R.3    Attwell, D.4
  • 37
    • 0033548643 scopus 로고    scopus 로고
    • Stereoselective neuroprotection by novel 2,3-benzodiazepine non-competitive AMPA antagonist against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures
    • Mar 12;
    • May, P.C.; Robison, P.M.; Fuson, K.S. Stereoselective neuroprotection by novel 2,3-benzodiazepine non-competitive AMPA antagonist against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures. Neurosci Lett. 1999; Mar 12; 262(3), 219-21.
    • (1999) Neurosci Lett , vol.262 , Issue.3 , pp. 219-221
    • May, P.C.1    Robison, P.M.2    Fuson, K.S.3
  • 39
    • 0033028848 scopus 로고    scopus 로고
    • BIIR 561 CL, a novel combined antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and voltage-dependent sodium channels with anticonvulsive and neuroprotective properties
    • Jun;
    • Weiser, T.; Brenner, M.; Palluk, R.; Bechtel, W.D.; Ceci, A.; Brambilla, A.; Ensinger, H.A.; Sagrada, A.; Wienrich, M. BIIR 561 CL, a novel combined antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and voltage-dependent sodium channels with anticonvulsive and neuroprotective properties. J Pharmacol Exp Ther. 1999; Jun; 289(3), 1343-9.
    • (1999) J Pharmacol Exp Ther , vol.289 , Issue.3 , pp. 1343-1349
    • Weiser, T.1    Brenner, M.2    Palluk, R.3    Bechtel, W.D.4    Ceci, A.5    Brambilla, A.6    Ensinger, H.A.7    Sagrada, A.8    Wienrich, M.9
  • 40
    • 0036963806 scopus 로고    scopus 로고
    • Takahashi, M.; Kohara, A.; Shishikura, J.; Kawasaki-Yatsugi, S.; Ni, J.W.; Yatsugi, S.; Sakamoto, S.; Okada, M.; Shimizu-Sasamata, M.; Yamaguchi, T. YM872, a selective, potent and highly water-soluble alpha-amino-3- hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. CNS Drug Rev. 2002; Winter; 8(4), 337-52.
    • Takahashi, M.; Kohara, A.; Shishikura, J.; Kawasaki-Yatsugi, S.; Ni, J.W.; Yatsugi, S.; Sakamoto, S.; Okada, M.; Shimizu-Sasamata, M.; Yamaguchi, T. YM872, a selective, potent and highly water-soluble alpha-amino-3- hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. CNS Drug Rev. 2002; Winter; 8(4), 337-52.
  • 41
    • 0037414703 scopus 로고    scopus 로고
    • Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model
    • Jan 3;
    • Suzuki, M.; Sasamata, M.; Miyata, K. Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model. Brain Res. 2003; Jan 3; 959(1), 169-72.
    • (2003) Brain Res , vol.959 , Issue.1 , pp. 169-172
    • Suzuki, M.1    Sasamata, M.2    Miyata, K.3
  • 42
    • 21544447526 scopus 로고    scopus 로고
    • Regulation of blood coagulation by the protein C anticoagulant pathwaypathway, novel insights into structure-function relationships and molecular recognition
    • Dahlbäck, B.; Villoutreix, B.O. Regulation of blood coagulation by the protein C anticoagulant pathwaypathway, novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol. 2005; 25, 1311-1320.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1311-1320
    • Dahlbäck, B.1    Villoutreix, B.O.2
  • 43
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce, D.E.; Gelbert, L.; Ciaccia, A.; Dehoff, B.; Grinnell, B.W. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001; 276, 11199-11203.
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    Dehoff, B.4    Grinnell, B.W.5
  • 44
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • Cheng, T.; Liu, D.; Griffin, J.H.; et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003; 9, 338-342.
    • (2003) Nat Med , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3
  • 45
    • 0038115229 scopus 로고    scopus 로고
    • Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1
    • Domotor, E.; Benzakour, O.; Griffin, J.H.; et al. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003; 101, 4797- 4801.
    • (2003) Blood , vol.101 , pp. 4797-4801
    • Domotor, E.1    Benzakour, O.2    Griffin, J.H.3
  • 46
    • 0038682435 scopus 로고    scopus 로고
    • Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor
    • Mosnier, L.O.; Griffin, J.H. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003; 373, 65-70. 19.
    • (2003) Biochem J , vol.373 , Issue.65-70 , pp. 19
    • Mosnier, L.O.1    Griffin, J.H.2
  • 47
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald, M.; Petrovan, R.J.; Donner, A.; Mueller, B.M.; Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002; 296, 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 48
    • 0035799374 scopus 로고    scopus 로고
    • Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke
    • Apr 3;
    • Shibata, M.; Kumar, S.R.; Amar, A.; Fernandez, J.A.; Hofman, F.; Griffin, J.H.; Zlokovic, B.V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001; Apr 3; 103(13), 1799-805.
    • (2001) Circulation , vol.103 , Issue.13 , pp. 1799-1805
    • Shibata, M.1    Kumar, S.R.2    Amar, A.3    Fernandez, J.A.4    Hofman, F.5    Griffin, J.H.6    Zlokovic, B.V.7
  • 50
    • 65549085166 scopus 로고    scopus 로고
    • Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity
    • May;
    • Wang, Y.; Thiyagarajan, M.; Chow, N.; Singh, I.; Guo, H.; Davis, T.P.; Zlokovic, B.V. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009; May; 40(5), 1864-9.
    • (2009) Stroke , vol.40 , Issue.5 , pp. 1864-1869
    • Wang, Y.1    Thiyagarajan, M.2    Chow, N.3    Singh, I.4    Guo, H.5    Davis, T.P.6    Zlokovic, B.V.7
  • 51
    • 39449083733 scopus 로고    scopus 로고
    • Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging
    • Slemmer, J.E.; Shacka, J.J.; Sweeney, M.I.; Weber, J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem. 2008; 15(4), 404-14.
    • (2008) Curr Med Chem , vol.15 , Issue.4 , pp. 404-414
    • Slemmer, J.E.1    Shacka, J.J.2    Sweeney, M.I.3    Weber, J.T.4
  • 52
  • 53
    • 62849084592 scopus 로고    scopus 로고
    • Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial)
    • Shinohara, Y.; Saito, I.; Kobayashi, S.; Uchiyama, S. Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial). Cerebrovasc Dis. 2009; 27(5), 485-92.
    • (2009) Cerebrovasc Dis , vol.27 , Issue.5 , pp. 485-492
    • Shinohara, Y.1    Saito, I.2    Kobayashi, S.3    Uchiyama, S.4
  • 54
    • 67649367539 scopus 로고    scopus 로고
    • Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model
    • Aug 18;
    • Ueno, Y.; Zhang, N.; Miyamoto, N.; Tanaka, R.; Hattori, N.; Urabe, T. Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model. Neuroscience. 2009 Aug 18; 162(2), 317-327.
    • (2009) Neuroscience , vol.162 , Issue.2 , pp. 317-327
    • Ueno, Y.1    Zhang, N.2    Miyamoto, N.3    Tanaka, R.4    Hattori, N.5    Urabe, T.6
  • 55
    • 67649736219 scopus 로고    scopus 로고
    • Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction
    • Ohta, Y.; Takamatsu, K.; Fukushima, T.; Ikegami, S.; Takeda, I.; Ota, T.; Goto, K.; Abe, K. Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction. Intern Med. 2009; 48(8), 593-6.
    • (2009) Intern Med , vol.48 , Issue.8 , pp. 593-596
    • Ohta, Y.1    Takamatsu, K.2    Fukushima, T.3    Ikegami, S.4    Takeda, I.5    Ota, T.6    Goto, K.7    Abe, K.8
  • 56
    • 0032709479 scopus 로고    scopus 로고
    • A randomized efficacy trial of citicoline in patients with acute ischemic stroke
    • Dec;
    • Clark, W.M.; Williams, B.J.; Selzer, K.A.; Zweifler, R.M.; Sabounjian, L.A.; Gammans, R.E. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke. 1999; Dec; 30(12), 2592-7.
    • (1999) Stroke , vol.30 , Issue.12 , pp. 2592-2597
    • Clark, W.M.1    Williams, B.J.2    Selzer, K.A.3    Zweifler, R.M.4    Sabounjian, L.A.5    Gammans, R.E.6
  • 57
    • 0035856456 scopus 로고    scopus 로고
    • Citicoline Stroke Study Group. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients
    • Nov 13;
    • Clark, W.M.; Wechsler, L.R.; Sabounjian, L.A.; Schwiderski, U.E. Citicoline Stroke Study Group. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology. 2001; Nov 13; 57(9), 1595-602.
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1595-1602
    • Clark, W.M.1    Wechsler, L.R.2    Sabounjian, L.A.3    Schwiderski, U.E.4
  • 59
    • 0032897259 scopus 로고    scopus 로고
    • Parallel dose-response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia
    • Jan 8;
    • Kawaguchi, K.; Henshall, D.C.; Simon, R.P. Parallel dose-response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia. Eur J Pharmacol. 1999; Jan 8; 364(2-3), 99-105.
    • (1999) Eur J Pharmacol , vol.364 , Issue.2-3 , pp. 99-105
    • Kawaguchi, K.1    Henshall, D.C.2    Simon, R.P.3
  • 63
    • 36949019358 scopus 로고    scopus 로고
    • Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke
    • Shah, Q.A.; Georgiadis, A.; Suri, M.F.; Rodriguez, G.; Qureshi, A.I. Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke Neurocrit Care. 2007; 7(1), 53-7.
    • (2007) Neurocrit Care , vol.7 , Issue.1 , pp. 53-57
    • Shah, Q.A.1    Georgiadis, A.2    Suri, M.F.3    Rodriguez, G.4    Qureshi, A.I.5
  • 64
    • 4444351598 scopus 로고    scopus 로고
    • Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats
    • Oct 1;
    • Wei, L.; Ying, D.J.; Cui, L.; Langsdorf, J.; Yu, S.P. Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats. Brain Res. 2004; Oct 1; 1022(1-2), 54-61.
    • (2004) Brain Res , vol.1022 , Issue.1-2 , pp. 54-61
    • Wei, L.1    Ying, D.J.2    Cui, L.3    Langsdorf, J.4    Yu, S.P.5
  • 65
    • 0642375799 scopus 로고    scopus 로고
    • The mechanisms of cell death in focal cerebral ischemia highlight neuroprotective perspectives by anti-caspase therapy
    • Oct 15;
    • Onténiente, B.; Couriaud, C.; Braudeau, J.; Benchoua, A.; Guégan, C. The mechanisms of cell death in focal cerebral ischemia highlight neuroprotective perspectives by anti-caspase therapy. Biochem Pharmacol. 2003; Oct 15; 66(8), 1643-9.
    • (2003) Biochem Pharmacol , vol.66 , Issue.8 , pp. 1643-1649
    • Onténiente, B.1    Couriaud, C.2    Braudeau, J.3    Benchoua, A.4    Guégan, C.5
  • 66
    • 43249127097 scopus 로고    scopus 로고
    • Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat
    • May 28;
    • Zhang, H.; Gao, X.; Yan, Z.; Ren, C.; Shimohata, T.; Steinberg, G.K.; Zhao, H. Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat. Neuroreport. 2008; May 28; 19(8), 821-4.
    • (2008) Neuroreport , vol.19 , Issue.8 , pp. 821-824
    • Zhang, H.1    Gao, X.2    Yan, Z.3    Ren, C.4    Shimohata, T.5    Steinberg, G.K.6    Zhao, H.7
  • 67
    • 2142815707 scopus 로고    scopus 로고
    • Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    • May 29;
    • Wen, Y.; Onyewuchi, O.; Yang, S.; Liu, R.; Simpkins, J.W. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res. 2004; May 29; 1009(1-2), 1-8.
    • (2004) Brain Res , vol.1009 , Issue.1-2 , pp. 1-8
    • Wen, Y.1    Onyewuchi, O.2    Yang, S.3    Liu, R.4    Simpkins, J.W.5
  • 68
    • 56749177114 scopus 로고    scopus 로고
    • Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke
    • Dec;
    • Xiong, M.; Zhang, T.; Zhang, L.M.; Lu, S.D.; Huang, Y.L.; Sun, F.Y. Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke. Neurobiol Dis. 2008; Dec; 32(3), 433-41.
    • (2008) Neurobiol Dis , vol.32 , Issue.3 , pp. 433-441
    • Xiong, M.1    Zhang, T.2    Zhang, L.M.3    Lu, S.D.4    Huang, Y.L.5    Sun, F.Y.6
  • 70
    • 34547124824 scopus 로고    scopus 로고
    • Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH
    • Braun, J.S.; Prass, K.; Dirnagl, U.; Meisel, A.; Meisel, C. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Exp Neurol. 2007; (2), 183-91.
    • (2007) Exp Neurol , vol.2 , pp. 183-191
    • Braun, J.S.1    Prass, K.2    Dirnagl, U.3    Meisel, A.4    Meisel, C.5
  • 71
    • 1242274413 scopus 로고    scopus 로고
    • Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke, relationships with nerve growth factor
    • Feb 18;
    • Saito, A.; Narasimhan, P.; Hayashi, T.; Okuno, S.; Ferrand-Drake, M.; Chan, P.H. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke, relationships with nerve growth factor. J Neurosci. 2004; Feb 18; 24(7), 1584-93.
    • (2004) J Neurosci , vol.24 , Issue.7 , pp. 1584-1593
    • Saito, A.1    Narasimhan, P.2    Hayashi, T.3    Okuno, S.4    Ferrand-Drake, M.5    Chan, P.H.6
  • 72
    • 0034131832 scopus 로고    scopus 로고
    • Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo
    • Feb;
    • Wiessner, C.; Sauer, D.; Alaimo, D.; Allegrini, P.R. Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo. Cell Mol Biol (Noisy-le-grand). 2000; Feb; 46(1), 53-62.
    • (2000) Cell Mol Biol (Noisy-le-grand) , vol.46 , Issue.1 , pp. 53-62
    • Wiessner, C.1    Sauer, D.2    Alaimo, D.3    Allegrini, P.R.4
  • 73
    • 57049115942 scopus 로고    scopus 로고
    • Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebral ischemia
    • Oct;
    • Zhou, C.; Li, C.; Yu, H.M.; Zhang, F.; Han, D.; Zhang, G.Y. Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebral ischemia. J Neurosci Res. 2008; Oct; 86(13), 2973-83.
    • (2008) J Neurosci Res , vol.86 , Issue.13 , pp. 2973-2983
    • Zhou, C.1    Li, C.2    Yu, H.M.3    Zhang, F.4    Han, D.5    Zhang, G.Y.6
  • 74
    • 0035044262 scopus 로고    scopus 로고
    • Sah Rgamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia
    • Apr;
    • Schwartz-Bloom, R.D. Sah Rgamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. J Neurochem. 2001; Apr; 77(2), 353-71.
    • (2001) J Neurochem , vol.77 , Issue.2 , pp. 353-371
    • Schwartz-Bloom, R.D.1
  • 75
    • 36849040517 scopus 로고    scopus 로고
    • Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion
    • Dec 19;
    • Zhang, F.; Li, C.; Wang, R.; Han, D.; Zhang, Q.G.; Zhou, C.; Yu, H.M.; Zhang, G.Y. Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience. 2007; Dec 19; 150(4), 938-49.
    • (2007) Neuroscience , vol.150 , Issue.4 , pp. 938-949
    • Zhang, F.1    Li, C.2    Wang, R.3    Han, D.4    Zhang, Q.G.5    Zhou, C.6    Yu, H.M.7    Zhang, G.Y.8
  • 76
    • 42749097879 scopus 로고    scopus 로고
    • Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade
    • Jun;
    • Xu, J.; Li, C.; Yin, X.H.; Zhang, G.Y. Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. Neuropharmacology. 2008; Jun; 54(7), 1029-40.
    • (2008) Neuropharmacology , vol.54 , Issue.7 , pp. 1029-1040
    • Xu, J.1    Li, C.2    Yin, X.H.3    Zhang, G.Y.4
  • 77
    • 36148971162 scopus 로고    scopus 로고
    • Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
    • Oct;
    • Egashira, N.; Hayakawa, K.; Osajima, M.; Mishima, K.; Iwasaki, K.; Oishi, R.; Fujiwara, M. Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci. 2007; Oct; 105(2), 211-4.
    • (2007) J Pharmacol Sci , vol.105 , Issue.2 , pp. 211-214
    • Egashira, N.1    Hayakawa, K.2    Osajima, M.3    Mishima, K.4    Iwasaki, K.5    Oishi, R.6    Fujiwara, M.7
  • 78
    • 29744470779 scopus 로고    scopus 로고
    • Activation of neuroprotective pathways by metabotropic group I glutamate receptors, a potential target for drug discovery?
    • Aug;
    • Baskys, A.; Fang, L.; Bayazitov, I. Activation of neuroprotective pathways by metabotropic group I glutamate receptors, a potential target for drug discovery? Ann N Y Acad Sci. 2005; Aug; 1053, 55-73.
    • (2005) Ann N Y Acad Sci , vol.1053 , pp. 55-73
    • Baskys, A.1    Fang, L.2    Bayazitov, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.