Interleukin-17-producing γδ+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-β

Immunology

Volumn 129, Issue 2, 2010, Pages 197-206

  Han, Gencheng ^a   Wang, Renxi ^a   Chen, Guojiang ^a   Wang, Jianan ^a   Xu, Ruonan ^a   Wang, Liyan ^a   Feng, Jiannan ^a   Li, Xia ^b   Guo, Renfeng ^c   Fu, Li ^d   Shen, Beifen ^a   Li, Yan ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b HENAN UNIVERSITY   (China)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

T cells; Autoimmune diabetes; Interleukin 17; Non obese diabetic (NOD); Transforming growth factor

Indexed keywords

INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTECTION; SPLEEN CELL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, INBRED NOD; MICE, SCID; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPLEEN; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 73949129793     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03166.x     Document Type: Article

References (32)

1. Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005 23 : 447 485.
2. Savinov AY, Wong FS, Chervonsky AV. IFN-g affects the homing of diabetogenic T cells. J Immunol 2001 167 : 6637 6643.
3. Han G, Li Y, Wang J et al. Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD (500-585). J Immunol 2005 174 : 4516 4524.
4. Cooke A, Phillips JM, Parish NM. Tolerogenic strategies to halt or prevent type 1 diabetes. Nat Immunol 2001 2 : 810.
5. Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005 6 : 1133 1141.
6. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003 171 : 6173 6177.
7. Cua DJ, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003 421 : 744 748.
8. Hashimoto T, Akiyama K, Kobayashi N, Mori A. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int Arch Allergy Immunol 2005 137 : 51 4.
9. Bending D, De La Pea H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B, Cooke A. Highly purified Th17 cells from BDC2·5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 2009, doi :.
10. Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 2009 39 : 216 224.
11. Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by γδT cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006 177 : 4662 4669.
12. Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vγ1γδT cells control early infiltration of Neutrophils after Escherichia coli infection via IL-17 production. J Immunol 2007 178 : 4466 4472.
13. Bhagat G, Naiyer AJ, Shah JG, Harper J, Jabri B, Wang TC, Green PH, Manavalan JS. Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 2008 118 : 281 293.
14. Harrison LC, DempseyCollier M, Kramer DR, Takahashi K. Aerosol insulin induces regulatory CD8 gd T cells that prevent murine insulin-dependent diabetes. J Exp Med 1996 184 : 2167 2174.
15. Seo N, Tokura Y, Takigawa M, Egawa K. Depletion of IL-10- and TGF-b-producing regulatory gd T cells by administering a daunomycin -conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells. J Immunol 1999 163 : 242 249.
16. Locke NR, Stankovic S, Funda DP, Harrison LC. TCR gd intraepithelial lymphocytes are required for self-tolerance. J Immunol 2006 176 : 6553 6559.
17. Nagaeva O, Jonsson L, Mincheva-Nilsson L. Dominant IL-10 and TGF-b mRNA expression in gdT cells of human early pregnancy decidua suggests immunoregulatory potential. Am J Reprod Immunol 2002 48 : 9 17.
18. Peng G, Wang H, Peng W, Kiniwa Y, Seo KH, Wang R. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique Toll-like receptor signaling pathway. Immunity 2007 27 : 334 348.
19. Tschöp J, Martignoni A, Goetzman HS, et al. gdT cells mitigate the organ injury and mortality of sepsis. J Leukoc Biol. 2008 83 : 1 8.
20. Carding SR, Egan PJ. γδT cells: functional plasticity and heterogeneity. Nat Rev Immunol 2002 2 : 336 345.
21. Kohyama S, Ohno S, Isoda A et al. IL-23 enhances host defense against Vaccinia virus infection via a mechanism partly involving IL-17. J Immunol 2007 179 : 3917 3925.
22. Yu S, Sharp GC, Braley-Mullen H. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma deficient NOD.H-2h4 Mice. J Immunol, 2008 181 : 2238 2245.
23. Nakae S, Iwakura Y, Suto H, Galli SJ. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 2007 81 : 1258 1268.
24. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005 6 : 1123 1132.
25. Langrish CL, Chen Y, Blumenschein WM et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005 201 : 233 240.
26. Korn T, Reddy J, Gao W et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007 13 : 4.
27. Roark CL, Simonian PL, Fontenot AP, Born WB, O'Brien RL. Gamma delta T cells: an important source of IL-17. Curr Opin Immunol 2008 20 : 1 5.
28. Cheng L, Cui Y, Shao H et al. Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells. J Neuroimmunol 2008 203 : 3 11.
29. Thedrez A, Sabourin C, Gertner J, Devilder MC, Allain-Maillet S, Fournié JJ, Scotet E, Bonneville M. Self/non-self discrimination by gammadelta T cells: simple solutions for a complex. Immunol Rev 2007 215 : 123 135.
30. Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol 2007 179 : 5576 5583.
31. Romani L, Fallarino F, De Luca A et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008 451 : 211 215.
32. McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ. TGF-b and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nat Immun 2007 8 : 12.