Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells

Journal of Neuroimmunology

Volumn 203, Issue 1, 2008, Pages 3-11

  Cheng, Lan ^a   Cui, Yan ^a,c   Shao, Hui ^a   Han, Gencheng ^a   Zhu, Ling ^c   Huang, Yafei ^b   O'Brien, Rebecca L ^b   Born, Willi K ^b   Kaplan, Henry J ^a   Sun, Deming ^a,c  

^a University of Louisville School of Medicine   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

T cell; Antigen presentation; Interleukin 17; MHC class II

Indexed keywords

CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; EYE PROTEIN; HLA ANTIGEN CLASS 2; INTERLEUKIN 17; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; INTERSTITIAL RETINOL-BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; RETINOL BINDING PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; FEMALE; GAMMA DELTA T LYMPHOCYTE; IMMUNIZATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; C57BL MOUSE; CELL SEPARATION; CYTOLOGY; DOWN REGULATION; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL SEPARATION; DOWN-REGULATION; EYE PROTEINS; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RETINOL-BINDING PROTEINS; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS;

EID: 52949116812     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2008.06.007     Document Type: Article

References (42)

1. Andrew E.M., and Carding S.R. Murine γδ T cells in infections: beneficial or deleterious?. Microbes Infect. 7 (2005) 529-536
2. Avichezer D., Chan C.C., Silver P.B., Wiggert B., and Caspi R.R. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp. Eye Res. 71 (2000) 111-118
3. Born W., Cady C., Jones-Carson J., Mukasa A., Lahn M., and O'Brien R. Immunoregulatory functions of γδ T cells. Adv. Immunol. 71 (1999) 77-144
4. Born W.K., Reardon C.L., and O'Brien R.L. The function of γδ T cells in innate immunity. Curr. Opin. Immunol. 18 (2006) 31-38
5. Brandes M., Willimann K., and Moser B. Professional antigen-presentation function by human γδ T cells. Science 309 (2005) 264-268
6. Carding S.R., and Egan P.J. The importance of γδ T cells in the resolution of pathogen-induced inflammatory immune responses. Immunol. Rev. 173 (2000) 98-108
7. + T cells. J. Exp. Med. 172 (1990) 1225-1231
8. Collins R.A., Werling D., Duggan S.E., Bland A.P., Parsons K.R., and Howard C.J. γδ T cells present antigen to CD4+ ab T cells. J. Leuko Biol. 63 (1998) 707-714
9. D'Souza C.D., Cooper A.M., Frank A.A., Mazzaccaro R.J., Bloom B.R., and Orme I.M. An anti-inflammatory role for γδ T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J. Immunol. 158 (1997) 1217-1221
10. Fernandez N.C., Lozier A., Flament C., Ricciardi-Castognoli P., Bellet D., Suter M., Perricaudet M., Tursz T., maraskovsky E., and Zitvogel L. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 5 (1999) 405-411
11. Freedman M.S., Ruijs T.C.G., Selin L.K., and Antel J.P. Peripheral blood γδ T cells lyse fresh human brain-derived oligodendrocytes. Ann. Neurol. 30 (1991) 794-800
12. Fukushima K., Masuda T., Ohtani H., Sasaki I., Funayama Y., Matsuno S., and Nagura H. Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γδ in inflammatory bowel disease. Gastroenterology 101 (1991) 670-678
13. Goodman T., and Lefrancois L. Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function. J. Exp. Med. 170 (1989) 1569-1581
14. Haas W., Pereira P., and Tonegawa S. γδ cells. Ann. Rev. Immunol. 11 (1993) 637-685
15. Hohlfeld R., Engel A.G., Ii K., and Harper M.C. Polymyositis mediated by T lymphocytes that express the γδ receptor. N. Eng. J. Med. 324 (1991) 877-881
16. Janis E.M., Kaufmann S.H.E., Schwartz R.H., and Pardoll D.M. Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244 (1989) 713-716
17. + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein. J. Exp. Med. 171 (1990) 667-679
18. Kadowaki N., Antonenko S., Lau J.Y., and Liu Y.J. Natural interferon a/b-producing cells link innate and adaptive immunity. J. Exp. Med. 192 (2000) 219-226
19. Ladel C.H., Blum C., Dreher A., Reifenberg K., and Kaufmann S.H. Protective role of γ/δ T cells and a/b T cells in tuberculosis. Eur. J. Immunol. 25 (1995) 2877-2881
20. Lockhart E., Green A.M., and Flynn J.L. IL-17 production is dominated by γδ T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J. Immunol. 177 (2006) 4662-4669
21. Mak T.W., and Ferrick D.A. The γδ T-cell bridge - linking innate and acquired immunity. Nat. Med. 4 (1998) 764-765
22. Medzhitov R., and Janeway C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 (1997) 295-298
23. Medzhitov R., and Janeway C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 (1997) 295-298
24. Moser B., and Brandes M. γδ T cells: an alternative type of professional APC. Trends Immunol. 27 (2006) 112-118
25. Mukasa A., Lahn M., Pflum E.K., Born W., and O'Brien R.L. Evidence that the same γδ T cells respond during infection-induced and autoimmune inflammation. J. Immunol. 159 (1997) 5787-5794
26. O'Brien R.L., Happ M.P., Dallas A., Palmer E., Kubo R., and Born W.K. Stimulation of a major subset of lymphocytes expressing T cell receptor γ δ by an antigen derived from Mycobacterium tuberculosis. Cell 57 (1989) 667-674
27. Odyniec A., Szczepanik M., Mycko M.P., Stasiolek M., Raine C.S., and Selmaj K.W. Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production. J. Immunol. 173 (2004) 682-694
28. Peng G., Guo Z., Kiniwa Y., Voo K.S., Peng W., Fu T., Wang D.Y., Li Y., Wang H.Y., and Wang R.F. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309 (2005) 1380-1384
29. Peng Y., Shao H., Ke Y., Zhang P., Xiang J., Kaplan H.J., and Sun D. In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors. J. Immunol. 176 (2006) 5006-5014
30. Peterman G.M., Spencer C., Sperling A.I., and Bluestone J.A. Role of γδ T cells in murine collagen-induced arthritis. J. Immunol. 151 (1993) 6546-6558
31. Ponomarev E.D., and Dittel B.N. γδ T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J. Immunol. 174 (2005) 4678-4687
32. Rajan A.J., Asensio V.C., Campbell I.L., and Brosnan C.F. Experimental autoimmune encephalomyelitis on the SJL mouse: effect of γδ T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J. Immunol. 164 (2000) 2120-2130
33. Selmaj K., Brosnan C.F., and Raine C.S. Colocalization of lymphocytes bearing γδ T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 6452-6456
34. Shao H., Peng Y., Liao T., Wang M., Song M., Kaplan H.J., and Sun D. A shared epitope of the interphotoreceptor retinoid-binding protein (IRBP) recognized by the CD4+ and CD8+ autoreactive T cells. J. Immunol. 175 (2005) 1851-1857
35. Shimonkevitz R., Colburn C., Burnham J.A., Murray R.S., and Kotzin B.L. Clonal expansions of activated gamma/δ T cells in recent-onset multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 923-927
36. Skelsey M.E., Mellon J., and Niederkorn J.Y. γδ T cells are needed for ocular immune privilege and corneal graft survival. J. Immunol. 166 (2001) 4327-4333
37. Spahn T.W., Issazadah S., Salvin A.J., and Weiner H.L. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR d chain gene. Eur. J. Immunol. 29 (1999) 4060-4071
38. Sun D., Whitaker J.N., Huang Z., Liu D., Coleclough C., Wekerle H., and Raine C.S. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 Mice. J. Immunol. 166 (2001) 7579-7587
39. Sun D., Zhang Y., Wei B., Peiper S.C., Shao H., and Kaplan H.J. Encephalitogenic activity of truncated myelin oligodendrocyte glycoprotein (MOG) peptides and their recognition by CD8+ MOG-specific T cells on oligomeric MHC class I molecules. Int. Immunol. 15 (2003) 261-268
40. Tagawa T., Nishimura H., Yajima T., Hara H., Kishihara K., Matsuzaki G., Yoshino I., Maehara Y., and Yoshikai Y. Vδ1+ γδ T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice. J. Immunol. 173 (2004) 5156-5164
41. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann. Rev. Immunol. 13 (1995) 251-276
42. Tsuchiya T., Fukuda S., Hamada H., Nakamura A., Kohama Y., Ishikawa H., Tsujikawa K., and Yamamoto H. Role of γδ T cells in the inflammatory response of experimental colitis mice. J. Immunol. 171 (2003) 5507-5513