Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 21, 2009, Pages 7523-7530

  Prins, Louis H A ^a   Petzer, Jacobus P ^a   Malan, Sarei F ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Dual target directed ligands; Monoamine oxidase b; Nitric oxide synthase; Pteridine 2,4 dione

Indexed keywords

1,3 DIMETHYL 6 PHENYL 1H PTERIDINE 2,4 DIONE; 6 (3 CHLOROPHENYL) 1,3 DIMETHYL 1H PTERIDINE 2,4 DIONE; MOLECULAR SCAFFOLD; MONOAMINE OXIDASE B INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; PTERIDINE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); ENZYME INHIBITOR; MONOAMINE OXIDASE INHIBITOR; NEUROPROTECTIVE AGENT; NITRIC OXIDE SYNTHASE; PTERIDINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; RAT; ANIMAL; BABOON; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DEGENERATIVE DISEASE; DRUG ANTAGONISM; ENZYME ACTIVE SITE; HUMAN; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR CONFORMATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; PAPIO; PTERIDINES;

EID: 73949123501     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.019     Document Type: Article

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