Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 482-491

  Abbas, Safinaz E ^a   Awadallah, Fadi M ^a   Ibrahim, Nashwa A ^b   Gouda, Ahmed M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

Analgesic activity; Anti inflammatory activity; Pyrimidopyrrolizines; Pyrrolizines; Ulcerogenicity

Indexed keywords

3 (4 OXO 9 (4 TOLYLCARBAMOYL) 4,5,6,7 TETRAHYDRO 1H PYRIMIDO[5,4 A]PYRROLIZIN 2 YL)ACRYLIC ACID; 3 (4 OXO 9 (PHENYLCARBAMOYL) 4,5,6,7 TETRAHYDRO 1H PYRIMIDO[5,4 A]PYRROLIZIN 2 YL)ACRYLIC ACID; 4 [(6 AMINO 7 CYANO 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBONYL)AMINO]BENZOIC ACID; 6 [2 (3 BENZOYLPHENYL)PROPIONYLAMINO] 7 CYANO N (4 TOLYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 6 [2 (3 BENZOYLPHENYL)PROPIONYLAMINO] 7 CYANO N HENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 6 [2 (3 BENZOYLPHENYL)PROPIONYLAMINO] N (4 CHLOROPHENYL) 7 CYANO 2,37 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 6 AMINO 7 CYANO N (4 HYDROXYPHENYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 6 AMINO 7 CYANO N (4 NITROPHENYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 (1,3 DIOXOISOINDOINL 2 YL) N (4 TOLYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 (1,3 DIOXOISOINDOLIN 2 YL) N PHENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [(4 HYDROXY 3 METHOXYBENZYLIDENE)AMINO] N (4 TOLYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [(4 HYDROXY 3 METHOXYBENZYLIDENE)AMINO] N PHENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [(4 METHOXYBENZYLIDENE)AMINO] N (4 TOLYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [(4 METHOXYBENZYLIDENE)AMINO] N PHENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [2 (4 ISOBUTYLPHENYL)PROPIONYLAMINO] N (4 TOLYL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7 CYANO 6 [2 (4 ISOBUTYLPHENYL)PROPIONYLAMINO] N PHENYL 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; 7,13 DIOXO N (4 TOLYL) 2,3,7,13 TETRAHYDRO 1H PYRROLIZINO[1',2':5,6]PYRIMIDO[2,1 A]ISOINDOLE 5 CARBOXAMIDE; 7,13 DIOXO N PHENYL 2,3,7,13 TETRAHYDRO 1H PYRROLIZINO[1',2':5,6]PYRIMIDO[2,1 A]ISOINDOLE 5 CARBOXAMIDE; ACID ANHYDRIDE; ALDEHYDE; CARRAGEENAN; CHLORIDE; KETOROLAC; N (4 CHLOROPHENYL) 7 CYANO 6 (1,3 DIOXOISOINDOLIN 2 YL) 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 7 CYANO 6 [(4 HYDROXY 3 METHOXYBENZYLIDENE)AMINO] 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 7 CYANO 6 [(4 METHOXYBENZYLIDENEAMINO)] 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 7 CYANO 6 [2 (4 ISOBUTYLPHENYL)PROPIONYLAMINO] 2,3 DIHYDRO 1H PYRROLIZINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 7,13 DIOXO 2,3,7,13 TETRAHYDRO 1H PYRROLIZINO[1',2':5,6]PYRIMIDO[2,1 A]ISOINDOLE 5 CARBOXAMIDE; PYRROLIZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIC ACTIVITY; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCULATION; CHEMICAL REACTION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MODEL; DRUG SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; SCREENING; SPECTROSCOPY; ULCER; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; EDEMA; FEMALE; MALE; MICE; PYRROLES; RATS; ULCER;

EID: 73849091252     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.031     Document Type: Article

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