The pharmacological profile of ML3000: A new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

Inflammopharmacology

Volumn 9, Issue 1-2, 2001, Pages 113-124

  Tries, S ^a   Laufer, S ^b  

^a TEVA PHARMACEUTICALS   (Israel)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

5 lipoxygenase; 2,2 dimethyl 6 (4 chlorophenyl) 7 phenyl 2,3 dihydro 1H pyrrolizine 5 yl acetic acid; Anti inflammatory; Cyclooxygenase; Gastrointestinal; Inflammation; ML3000; NSAIDs

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; DICLOFENAC; INDOMETACIN; LEUKOTRIENE B4; LICOFELONE; LIPOXYGENASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRROLIZINE DERIVATIVE;

ACUTE DISEASE; ARACHIDONIC ACID METABOLISM; ASTHMA; CHRONIC INFLAMMATION; CONFERENCE PAPER; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; FEVER; GASTROINTESTINAL SYMPTOM; HUMAN; INFLAMMATION; MONKEY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

EID: 0034940687     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/156856001300248380     Document Type: Conference Paper

References (11)

1. The effects of ML3000 on antigen-induced responses in sheep
2. General pharmacology of [2,2-Dimethyl-6-(4-chlorophenyl) -7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals
3. Initial clinical studies with ML3000 in osteoarthritis
4. Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl) -7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat
5. Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]- acetic acid
6. Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage
7. ML3000 reduces gastric prostaglandin synthesis without causing mucosal injury