Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 2206-2215

  Vaccarino, Anthony L ^a,c   Paul, Dennis ^a,b   Mukherjee, Pranab K ^a   Rodríguez de Turco, Elena B ^a   Marcheselli, Victor L ^a   Xu, Liang ^c   Trudell, Mark L ^c   Minguez, J M ^d   Matia M P ^d   Sunkel, Carlos ^d   Alvarez Builla, Julio ^d   Bazan, Nicolas G ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEW ORLEANS   (United States)

^d UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Acetaminophen; Analgesic; Fas ligand constitutive androstane receptor; Glutathione; Hepatotoxicity

Indexed keywords

AMIDE; AMINOTRANSFERASE; CONSTITUTIVE ANDROSTANE RECEPTOR; FAS LIGAND; GLUTATHIONE; INDOMETACIN; N (4 HYDROXYPHENYL) 2 (2,3 DIHYDRO 3 OXO 1,2 BENZISOTHIAZOL 2 YL 1,1 DIOXIDE)ACETAMIDE; PARACETAMOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; DISEASE MODEL; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; EVALUATION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PAIN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; TOXICITY TESTING; UPREGULATION;

ACETAMINOPHEN; ANIMALS; DRUG EVALUATION, PRECLINICAL; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE;

EID: 33846629021     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.054     Document Type: Article

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