Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 727-737

  Koehler, Lena ^a   Graf, Franziska ^a   Bergmann, Ralf ^a   Steinbach, Jörg ^a   Pietzsch, Jens ^a   Wuest, Frank ^a,b  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cell cycle; Cyclin dependent kinase 4 inhibitor; Iodine 124; Positron emission tomography (PET)

Indexed keywords

8 CYCLOPENTYL 6 IODO 5 METHYL 2 (4 PIPERAZIN 1 YL PHENYLAMINO) 8H PYRIDOL[2,3 D]PYRIMIDIN 7 ONE I 124; 8 CYCLOPENTYL 6 IODO 5 METHYL 2 [5 (PIPERAZIN 1 YL)PYRIDIN 2 YLAMINO] 8H PYRIDOL[2,3 D]PYRIMIDIN 7 ONE I 124; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HT29; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; LIVER METABOLISM; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; SQUAMOUS CELL CARCINOMA; STEREOCHEMISTRY; TUMOR MODEL; TUMOR XENOGRAFT;

ANIMALS; BIOLOGICAL TRANSPORT; CYCLIN-DEPENDENT KINASE 4; DRUG DESIGN; DRUG STABILITY; GENE EXPRESSION REGULATION; HT29 CELLS; HUMANS; HYDROPHOBICITY; IODINE RADIOISOTOPES; MALE; MICE; MOLECULAR IMAGING; POSITRON-EMISSION TOMOGRAPHY; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS; TISSUE DISTRIBUTION;

EID: 73549121506     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.020     Document Type: Article

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