Cantilever biosensors in drug discovery

Expert Opinion on Drug Discovery

Volumn 4, Issue 12, 2009, Pages 1237-1251

  Xu, Sen ^a   Mutharasan, Raj ^a  

^a Drexel University   (United States)

Author keywords

Biomarker screening; Biomolecular interaction; High sensitivity; High throughput; Label free

Indexed keywords

BIOLOGICAL MARKER; MEMBRANE PROTEIN; TUMOR MARKER;

BIOSENSOR; CANTILEVER BIOSENSOR; CONTROLLED STUDY; DNA HYBRIDIZATION; DRUG TARGETING; GENE INTERACTION; HIGH THROUGHPUT SCREENING; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN INTERACTION; REVIEW;

EID: 73549120405     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460440903386643     Document Type: Review

References (106)

1. Bunney WE, Bunney BG, Vawter MP, et al. Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 2003;160:657-666
2. Debouck C, Goodfellow PN. DNA microarrays in drug discovery and development. Nat Genet 1999;21:48-50
3. Kumble KD. Protein microarrays: new tools for pharmaceutical development. Anal Bioanal Chem 2003;377:812-819
4. Vo-Dinh T, Scaffidi J, Gregas M, et al. Applications of fiber-optics-based nanosensors to drug discovery. Expert Opin Drug Discov 2009;4:889-900
5. Yu DH, Blankert B, Vire JC, et al. Biosensors in drug discovery and drug analysis. Anal Lett 2005;38:1687-1701
6. Cooper MA. Optical biosensors in drug discovery. Nat Rev Drug Discov 2002;1:515-528
7. Keusgen M. Biosensors: new approaches in drug discovery. Naturwissenschaften 2002;89:433-444
8. Cunningham BT, Laing LG. Advantages and application of label-free detection assays in drug screening. Expert Opin Drug Discov 2008;3:891-901
9. Cooper MA. Biosensor profiling of molecular interactions in pharmacology. Curr Opin Pharm 2003;3:557-562
10. Thevenot DR, Toth K, Durst RA, et al. Electrochemical biosensors: Recommended definitions and classification-(Technical Report). Pure Appl Chem 1999;71:2333-2348
11. Tatsuma T, Watanabe Y, Oyama N, et al. Multichannel quartz crystal microbalance. Anal Chem 1999;71:3632-3636
12. Dostalek J, Vaisocherova H, Homola J. Multichannel surface plasmon resonance biosensor with wavelength division multiplexing. Sens Actuators B Chem 2005;108:758-764
13. Goeders KM, Colton JS, Bottomley LA. Microcantilevers: sensing chemical interactions via mechanical motion. Chem Rev 2008;108:522-542
14. Waggoner PS, Craighead HG. Micro- and nanomechanical sensors for environmental, chemical, and biological detection. Lab Chip 2007;7:1238-1255
15. Lavrik NV, Sepaniak MJ, Datskos PG. Cantilever transducers as a platform for chemical and biological sensors. Rev Sci Instrum 2004;75:2229-2253
16. Raiteri R, Grattarola M, Butt HJ, et al. Micromechanical cantilever-based biosensors. Sens Actuators B Chem 2001;79:115-126
17. Maraldo D, Rijal K, Campbell G, et al. Method for label-free detection of femtogram quantities of biologics in flowing liquid samples. Anal Chem 2007;79:2762-2770
18. Rijal K, Mutharasan R. Method for measuring the self-assembly of alkanethiols on gold at femtomolar concentrations. Langmuir 2007;23:6856-6863
19. Fritz J, Baller MK, Lang HP, et al. Translating biomolecular recognition into nanomechanics. Science 2000;288:316-318
20. McKendry R, Zhang JY, Arntz Y, et al. Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array. Proc Natl Acad Sci USA 2002;99:9783-9788
21. Wu GH, Datar RH, Hansen KM, et al. Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nat Biotechnol 2001;19:856-860
22. Arntz Y, Seelig JD, Lang HP, et al. Label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 2003;14:86-90
23. Burg TP, Godin M, Knudsen SM, et al. Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 2007;446:1066-1069
24. Campbell GA, Mutharasan R. Piezoelectric-excited millimeter-sized cantilever (PEMC) sensors detect Bacillus anthracis at 300 spores/mL. Biosens Bioelectron 2006;21:1684-1692
25. Campbell GA, Mutharasan R. Detection of pathogen Escherichia coli O157: H7 using self-excited PZT-glass microcantilevers. Biosens Bioelectron 2005;21:462-473
26. Davila AP, Jang J, Gupta AK, et al. Microresonator mass sensors for detection of Bacillus anthracis Sterne spores in air and water. Biosens Bioelectron 2007;22:3028-3035
27. Gupta A, Akin D, Bashir R. Single virus particle mass detection using microresonators with nanoscale thickness. Appl Phys Lett 2004;84:1976-1978
28. Moulin AM, O'Shea SJ, Welland ME. Microcantilever-based biosensors. Ultramicroscopy 2000;82:23-31
29. Hwang KS, Jeon HK, Lee SM, et al. Quantification of disease marker in undiluted serum using an actuating layer-embedded microcantilever. J Appl Phys 2009;105:102017
30. Maraldo D, Garcia FU, Mutharasan R. Method for quantification of a prostate cancer biomarker in urine without sample preparation. Anal Chem 2007;79:7683-7690
31. Maraldo D, Mutharasan R. 10-minute assay for detecting Escherichia coli O157: H7 in ground beef samples using piezoelectric-excited millimeter-size cantilever sensors. J Food Prot 2007;70:1670-1677 (Pubitemid 47076106)
32. Campbell GA, Uknalis J, Tu SI, et al. Detect of Escherichia coli O157: H7 in ground beef samples using piezoelectric excited millimeter-sized cantilever (PEMC) sensors. Biosens Bioelectron 2007;22:1296-1302
33. Maraldo D, Mutharasan R. Detection and confirmation of staphylococcal enterotoxin B in apple juice and milk using piezoelectric-excited millimeter-sized cantilever sensors at 2.5 fg/mL. Anal Chem 2007;79:7636-7643
34. Stony GG. The tension of metallic films deposited by electrolysis. Proc R Soc Lond Ser A 1909;82:172-175
35. Thundat T, Warmack RJ, Chen GY, et al. Thermal and ambient-induced deflections of scanning force microscope cantilevers. Appl Phys Lett 1994;64:2894-2896
36. Ilic B, Craighead HG, Krylov S, et al. Attogram detection using nanoelectromechanical oscillators. J Appl Phys 2004;95:3694-3703
37. Yang YT, Callegari C, Feng XL, et al. Zeptogram-scale nanomechanical mass sensing. Nano Lett 2006;6:583-586
38. Sader JE. Frequency response of cantilever beams immersed in viscous fluids with applications to the atomic force microscope. J Appl Phys 1998;84:64-76
39. Van Eysden CA, Sader JE. Frequency response of cantilever beams immersed in viscous fluids with applications to the atomic force microscope: arbitrary mode order. J Appl Phys 2007;101:044908
40. Braun T, Barwich V, Ghatkesar MK, et al. Micromechanical mass sensors for biomolecular detection in a physiological environment. Phys Rev E 2005;72:031907
41. Campbell GA, Mutharasan R. Use of piezoelectric-excited millimeter-sized cantilever sensors to measure albumin interaction with self-assembled monolayers of alkanethiols having different functional headgroups. Anal Chem 2006;78:2328-2334
42. Verbridge SS, Bellan LM, Parpia JM, et al. Optically driven resonance of nanoscale flexural oscillators in liquid. Nano Lett 2006;6:2109-2114
43. Vancura C, Lichtenberg J, Hierlemann A, et al. Characterization of magnetically actuated resonant cantilevers in viscous fluids. Appl Phys Lett 2005;87:162510
44. Waggoner PS, Tan CP, Bellan L, et al. High-Q, in-plane modes of nanomechanical resonators operated in air. J Appl Phys 2009;105:094315
45. Shekhawat G, Tark SH, Dravid VP. MOSFET-embedded microcantilevers for measuring deflection in biomolecular sensors. Science 2006;311:1592-1595
46. Hermanson GT. Bioconjugate Technique : Elsevier; 2008
47. Datar R, Kim S, Jeon S, et al. Cantilever sensors: nanomechanical tools for diagnostics. MRS Bull 2009;34:449-454
48. Braun T, Backmann N, Vogtli M, et al. Conformational change of bacteriorhodopsin quantitatively monitored by microcantilever sensors. Biophys J 2006;90:2970-2977
49. Shu W, Laurenson S, Knowles TPJ, et al. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors. Biosens Bioelectron 2008;24:233-237
50. Lee SM, Hwang KS, Yoon HJ, et al. Sensitivity enhancement of a dynamic mode microcantilever by stress inducer and mass inducer to detect PSA at low picogram levels. Lab Chip 2009;9:2683-2690
51. Yue M, Stachowiak JC, Lin H, et al. Label-free protein recognition two-dimensional array using nanomechanical sensors. Nano Lett 2008;8:520-524
52. Lee JH, Kim TS, Yoon KH. Effect of mass and stress on resonant frequency shift of functionalized Pb(Zr0.52Ti0.48)O3 thin film microcantilever for the detection of C-reactive protein. Appl Phys Lett 2004;84:3187-3189
53. Grogan C, Raiteri R, O'Connor GM, et al. Characterisation of an antibody coated microcantilever as a potential immuno-based biosensor. Biosens Bioelectron 2002;17:201-207
54. Moulin AM, O'Shea SJ, Badley RA, et al. Measuring surface-induced conformational changes in proteins. Langmuir 1999;15:8776-8779
55. Rijal K, Mutharasan R. PEMC-based method of measuring DNA hybridization at femtomolar concentration directly in human serum and in the presence of copious noncomplementary strands. Anal Chem 2007;79:7392-7400
56. Mertens J, Rogero C, Calleja M, et al. Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films. Nat Nanotechnol 2008;3:301-307
57. Su M, Li SU, Dravid VP. Microcantilever resonance-based DNA detection with nanoparticle probes. Appl Phys Lett 2003;82:3562-3564
58. Hansen KM, Ji HF, Wu GH, et al. Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches. Anal Chem 2001;73:1567-1571
59. Rijal K. Use of piezoelectric-excited millimeter-sized cantilever (PEMC) sensors for DNA-based detection of pathogens and disease conditions [Ph.D.]. Drexel University: Philadelphia; 2007
60. Shu WM, Laue ED, Seshia AA. Investigation of biotin-streptavidin binding interactions using microcantilever sensors. Biosens Bioelectron 2007;22:2003-2009
61. Hyun SJ, Kim HS, Kim YJ, et al. Mechanical detection of liposomes using piezoresistive cantilever. Sens Actuators B Chem 2006;117:415-419
62. Kooser A, Manygoats K, Eastman MP, et al. Investigation of the antigen antibody reaction between anti-bovine serum albumin (a-BSA) and bovine serum albumin (BSA) using piezoresistive microcantilever based sensors. Biosens Bioelectron 2003;19:503-508
63. Campbell GA, Mutharasan R. Detection and quantification of proteins using self-excited PZT-glass millimeter-sized cantilever. Biosens Bioelectron 2005;21:597-607 (Pubitemid 41398124)
64. Lam Y, Abu-Lail NI, Alam MS, et al. Using microcantilever deflection to detect HIV-1 envelope glycoprotein gp120. Nanomedicine 2006;2:222-229
65. Martins MCL, Fonseca C, Barbosa MA, et al. Albumin adsorption on alkanethiols self-assembled monolayers on gold electrodes studied by chronopotentiometry. Biomaterials 2003;24:3697-3706
66. Raorane DA, Lim MD, Chen FF, et al. Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. Nano Lett 2008;8:2968-2974
67. Dauksaite V, Lorentzen M, Besenbacher F, et al. Antibody-based protein detection using piezoresistive cantilever arrays. Nanotechnology 2007;18:125503
68. Hwang KS, Lee SM, Eom K, et al. Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase. Biosens Bioelectron 2007;23:459-465
69. Kwon HS, Han KC, Hwang KS, et al. Development of a peptide inhibitor-based cantilever sensor assay for cyclic adenosine monophosphate-dependent protein kinase. Anal Chim Acta 2007;585:344-349
70. Leifert WR, Aloia AL, Bucco O, et al. G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches. J Biomol Screen 2005;10:765-779
71. Zhang Y, Venkatachalan SP, Xu H, et al. Micromechanical measurement of membrane receptor binding for label-free drug discovery. Biosens Bioelectron 2004;19:1473-1478
72. Braun T, Ghatkesar MK, Backmann N, et al. Quantitative time-resolved measurement of membrane protein-ligand interactions using microcantilever array sensors. Nat Nanotechnol 2009;4:179-185
73. Mukhopadhyay R, Sumbayev VV, Lorentzen M, et al. Cantilever sensor for nanomechanical detection of specific protein conformations. Nano Lett 2005;5:2385-2388
74. Ghatkesar MK, Lang HP, Gerber C, et al. Comprehensive characterization of molecular interactions based on nanomechanics. PLoS ONE 2008;3:e3610
75. Ndieyira JW, Watari M, Barrera AD, et al. Nanomechanical detection of antibiotic mucopeptide binding in a model for superbug drug resistance. Nat Nanotechnol 2008;3:691-696
76. Huber F, Hegner M, Gerber C, et al. Label free analysis of transcription factors using microcantilever arrays. Biosens Bioelectron 2006;21:1599-1605
77. Savran CA, Knudsen SM, Ellington AD, et al. Micromechanical detection of proteins using aptamer-based receptor molecules. Anal Chem 2004;76:3194-3198
78. Hwang KS, Lee JH, Park J, et al. In-situ quantitative analysis of a prostate-specific antigen (PSA) using a nanomechanical PZT cantilever. Lab Chip 2004;4:547-552
79. Lee JH, Hwang KS, Park J, et al. Immunoassay of prostate-specific antigen (PSA) using resonant frequency shift of piezoelectric nanomechanical microcantilever. Biosens Bioelectron 2005;20:2157-2162
80. Wee KW, Kang GY, Park J, et al. Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers. Biosens Bioelectron 2005;20:1932-1938
81. Maraldo D. Detection of proteins and pathogens in complex matrices using a novel cantilever design [Ph.D.]: Drexel University; 2007
82. Lee YH, Lee SK, Seo HJ, et al. Label-free detection of a biomarker with piezoelectric microcantilever based on mass microbalancing. J Assoc Lab Automat 2008;13:259-264
83. Capobianco JA, Shih WY, Yuan QA, et al. Label-free, all-electrical, in situ human epidermal growth receptor 2 detection. Rev Sci Instrum 2008;79:076101
84. Milburn C, Zhou J, Bravo O, et al. Sensing interactions between Vimentin antibodies and antigens for early cancer detection. J Biomed Nanotech 2005;1:30-38
85. Xia XY, Zhang ZX, Li XX. A Latin-cross-shaped integrated resonant cantilever with second torsion-mode resonance for ultra-resoluble bio-mass sensing. J Micromech Microeng 2008;18:035028
86. Liu YJ, Li XX, Zhang ZX, et al. Nanogram per milliliter-level immunologic detection of alpha-fetoprotein with integrated rotating-resonance microcantilevers for early-stage diagnosis of heptocellular carcinoma. Biomed Microdevices 2009;11:183-191
87. Maisel AS, Bhalla V, Braunwald E. Cardiac biomarkers: a contemporary status report. Nat Clin Pract Cardiovasc Med 2006;3:24-34
88. Kang GY, Han GY, Kang JY, et al. Label-free protein assay with site-directly immobilized antibody using self-actuating PZT cantilever. Sens Actuators B Chem 2006;117:332-338
89. Hwang KS, Eom K, Lee JH, et al. Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers. Appl Phys Lett 2006;89:173905
90. Knowles TPJ, Shu W, Huber F, et al. Label-free detection of amyloid growth with microcantilever sensors. Nanotechnology 2008;19:384007
91. Calleja M, Tamayo J, Nordstrom M, et al. Low-noise polymeric nanomechanical biosensors. Appl Phys Lett 2006;88:113901
92. Zhang J, Lang HP, Huber F, et al. Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA. Nat Nanotechnol 2006;1:214-220
93. Huber F, Backmann N, Grange W, et al. Analyzing gene expression using combined nanomechanical cantilever sensors. J Phys Conf Ser 2007;61:450-453
94. Calleja M, Nordstrom M, Alvarez M, et al. Highly sensitive polymer-based cantilever-sensors for DNA detection. Ultramicroscopy 2005;105:215-222
95. Lechuga LM, Tamayo J, Alvarez M, et al. A highly sensitive microsystem based on nanomechanical biosensors for genomics applications. Sens Actuators B Chem 2006;118:2-10
96. Vettiger P, Cross G, Despont M, et al. The "millipede"- Nanotechnology entering data storage. IEEE Trans Nanotechnol 2002;1:39-55
97. Yue M, Lin H, Dedrick DE, et al. A 2-D microcantilever array for multiplexed biomolecular analysis. J Microelectromech Syst 2004;13:290-299
98. Lim SH, Raorane D, Satyanarayana S, et al. Nano-chemo-mechanical sensor array platform for high-throughput chemical analysis. Sens Actuators B Chem 2006;119:466-474
99. Meyer GD, Moran-Mirabal JM, Branch DW, et al. Nonspecific binding removal from protein microarrays using thickness shear mode resonators. IEEE Sens J 2006;6:254-261
100. Cular S, Branch DW, Bhethanbotla VR, et al. Removal of nonspecifically bound proteins on microarrays using surface acoustic waves. IEEE Sens J 2008;8:314-320
101. Dultsev FN, Ostanin VP, Klenerman D. "Hearing" bond breakage. Measurement of bond rupture forces using a quartz crystal microbalance. Langmuir 2000;16:5036-5040
102. Cooper MA, Dultsev FN, Minson T, et al. Direct and sensitive detection of a human virus by rupture event scanning. Nat Biotechnol 2001;19:833-837
103. Yuan YJ, van der Werff MJ, Chen HG, et al. Bond rupture of biomolecular interactions by resonant quartz crystal. Anal Chem 2007;79:9039-9044
104. Wu J, Fu Z, Yan F, et al. Biomedical and clinical applications of immunoassays and immunosensors for tumor markers. Trends Anal Chem 2007;26:679-688
105. Chen CH, Hwang RZ, Huang LS, et al. A wireless bio-MEMS sensor for C-reactive protein detection based on nanomechanics. IEEE Trans Biomed Eng 2009;56:462-470
106. Amritsar J, Stiharu I, Packirisamy M. Bioenzymatic detection of troponin C using micro-opto-electro-mechanical systems. J Biomed Opt 2006;11:021010