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Bulky biphenyl phosphites are known to provide larger bite angles than phosphinites. The opening of the bite angle is necessary for high chiral recognition in the Pdcatalyzed alkylation reactions. See for example: a B. M. Trost, D. L. van Vranken, C. Bingel, J. Am. Chem. Soc. 1992, 114, 9327;
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Bulky biphenyl phosphites are known to provide larger bite angles than phosphinites. The opening of the bite angle is necessary for high chiral recognition in the Pdcatalyzed alkylation reactions. See for example: a) B. M. Trost, D. L. van Vranken, C. Bingel, J. Am. Chem. Soc. 1992, 114, 9327;
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29
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17744386953
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The flexibility offered by the biphenyl moiety can be used to fine-tune the chiral pocket formed upon complexation. Phosphite ligands have therefore proven to be highly versatile and active in Pd-catalyzed asymmetric substitution reactions, See for example a M. Dié-guez, O. Pàmies, C. Claver, J. Org. Chem. 2005, 70, 3363;
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The flexibility offered by the biphenyl moiety can be used to fine-tune the chiral pocket formed upon complexation. Phosphite ligands have therefore proven to be highly versatile and active in Pd-catalyzed asymmetric substitution reactions, See for example a) M. Dié-guez, O. Pàmies, C. Claver, J. Org. Chem. 2005, 70, 3363;
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29144447770
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The preliminary results were partly reported in the communication: Y Mata, O. Pàmies, M. Diéguez, C. Claver, Adv. Synth. Catal. 2005, 347, 1943.
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The preliminary results were partly reported in the communication: Y Mata, O. Pàmies, M. Diéguez, C. Claver, Adv. Synth. Catal. 2005, 347, 1943.
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73449149192
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This behavior contrasts with the effect of the oxazoline-substituent observed for related phosphinite-oxazoline ligands 1, for which enantioselectivities were higher when a methyl substituent was present
-
This behavior contrasts with the effect of the oxazoline-substituent observed for related phosphinite-oxazoline ligands 1, for which enantioselectivities were higher when a methyl substituent was present.
-
-
-
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40
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-
73449115139
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-
See ref.[5e
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[5e].
-
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41
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73449124593
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Changing the Pd catalyst concentration from 2 mol% down to 0.5 mol% has no affect on enantioselectivity.
-
Changing the Pd catalyst concentration from 2 mol% down to 0.5 mol% has no affect on enantioselectivity.
-
-
-
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42
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73449087157
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For some successful applications
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In contrast to Pd-catalytic systems, Ir, Ru, W and Mo catalysts provide very high selectivity in order for the attack at the non-terminal carbon to give the chiral product
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In contrast to Pd-catalytic systems, Ir, Ru, W and Mo catalysts provide very high selectivity in order for the attack at the non-terminal carbon to give the chiral product.
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The in situ NMR studies indicate that isomers 24A and 25A react 15 and 5 times faster than isomers 24B and 25B, respectively.
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