Buccal micronucleus frequency is associated with age in Down syndrome

Genetics and Molecular Research

Volumn 8, Issue 4, 2009, Pages 1231-1237

  Ferreira, F L S ^a   Pra D ^a   Martino Roth, M G ^a   Garcias, G L ^a,b  

^a CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^b FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

Author keywords

Buccal cells; Down syndrome; Genomic instability; Micronucleus

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CELL COUNT; CHEEK MUCOSA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; FAMILY; FEMALE; GENOMIC INSTABILITY; GROUPS BY AGE; HUMAN; INCOME; MALE; MICRONUCLEUS; MOUTH MUCOSA; SCHOOL CHILD;

ADOLESCENT; ADULT; AGE FACTORS; CASE-CONTROL STUDIES; CHEEK; CHILD; DOWN SYNDROME; FEMALE; HUMANS; MALE; MICRONUCLEUS TESTS; YOUNG ADULT;

EID: 73449083782     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/vol8-4gmr636     Document Type: Article

References (41)

1. Adler NE and Ostrove JM (1999). Socioeconomic status and health: what we know and what we don't. Ann. N. Y. Acad. Sci. 896: 3-15.
2. Ames BN (1989). Mutagenesis and carcinogenesis: endogenous and exogenous factors. Environ. Mol. Mutagen. 14 (Suppl 16): 66-77.
3. Anderson AJ, Stoltzner S, Lai F, Su J, et al. (2000). Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiol. Aging 21: 511-524.
4. Betancourt M, Ortiz R, Gonzalez C, Perez P, et al. (1995). Assessment of DNA damage in leukocytes from infected and malnourished children by single cell gel electrophoresis/comet assay. Mutat. Res. 331: 65-77.
5. Bonassi S, Znaor A, Ceppi M, Lando C, et al. (2007). An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28: 625-631.
6. Brugge KL, Nichols SL, Salmon DP, Hill LR, et al. (1994). Cognitive impairment in adults with Down's syndrome: similarities to early cognitive changes in Alzheimer's disease. Neurology 44: 232-238.
7. Busuttil RA, Dolle M, Campisi J and Vijga J (2004). Genomic instability, aging, and cellular senescence. Ann. N. Y. Acad. Sci. 1019: 245-255.
8. Caria H, Quintas A, Chaveca T and Rueff J (1997). The role of poly (ADP-ribose) polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells. Mutat. Res. 377: 269-277.
9. Coppede F, Migheli F, Bargagna S, Siciliano G, et al. (2009). Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring. Neurosci. Lett. 449: 15-19.
10. Fenech M (1998). Chromosomal damage rate, aging, and diet. Ann. N. Y. Acad. Sci. 854: 23-36.
11. Fenech M (2005). The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis 20: 255-269.
12. Franceschi C, Monti D, Scarfi MR, Zeni O, et al. (1992). Genomic instability and aging. Studies in centenarians (successful aging) and in patients with Down's syndrome (accelerated aging). Ann. N. Y. Acad. Sci. 663: 4-16.
13. Friedrisch JR, Pra D, Maluf SW, Bittar CM, et al. (2008). DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea. Mutat. Res. 649: 213-220.
14. Garcez ME, Peres W and Salvador M (2005). Oxidative stress and hematologic and biochemical parameters in individuals with Down syndrome. Mayo Clin. Proc. 80: 1607-1611.
15. Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, et al. (2008). The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps. Mutat. Res. 659: 93-108.
16. Kimura R, Kamino K, Yamamoto M, Nuripa A, et al. (2007). The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Hum. Mol. Genet. 16: 15-23.
17. Leonard S, Bower C, Petterson B and Leonard H (2000). Survival of infants born with Down's syndrome: 1980-96. Paediatr. Perinat. Epidemiol. 14: 163-171.
18. Lott IT and Head E (2005). Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol. Aging 26: 383-389.
19. Maluf SW and Erdtmann B (2001). Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer Genet. Cytogenet. 124: 71-75.
20. Migliore L, Testa A, Scarpato R, Pavese N, et al. (1997). Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Hum. Genet. 101: 299-305.
21. Migliore L, Botto N, Scarpato R, Petrozzi L, et al. (1999). Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients. Cytogenet. Cell Genet. 87: 41-46.
22. Migliore L, Boni G, Bernardini R, Trippi F, et al. (2006). Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age. Neurobiol. Aging 27: 710-716.
23. Ortiz R, Cortes E, Gonzalez C, Perez L, et al. (1995). Micronucleus frequency in spleen lymphocytes from severely malnourished rats during lactation. Environ. Mol. Mutagen. 26: 55-59.
24. Pedrollo O, Granzotto E, Lucas L, Meireles R, et al. (1999). Amendment de Sauté Publican Ago Portico de Syndrome de Down a Cicada de Pilots - RS - Brazil. In: 6° Congresso da Associação Médica do Rio Grande do Sul, Porto Alegre.
25. Petrozzi L, Lucetti C, Scarpato R, Gambaccini G, et al. (2002). Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients. Neurol. Sci. 23 (Suppl 2): S97-S98.
26. Picker JD and Fox DP (1986). Do curried foods produce micronuclei in buccal epithelial cells? Mutat. Res. 171: 185-188.
27. Raji NS and Rao KS (1998). Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients. Mech. Ageing Dev. 100: 85-101.
28. Roth JM, Restani RG, Goncalves TT, Sphor SL, et al. (2008). Genotoxicity evaluation in chronic renal patients undergoing hemodialysis and peritoneal dialysis, using the micronucleus test. Genet. Mol. Res. 7: 433-443.
29. Scarfi MR, Cossarizza A, Monti D, Bersani F, et al. (1990). Age-related increase of mitomycin C-induced micronuclei in lymphocytes from Down's syndrome subjects. Mutat. Res. 237: 247-252.
30. Shi Q and King RW (2005). Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437: 1038-1042.
31. Simko M, Kriehuber R, Weiss DG and Luben RA (1998). Effects of 50 Hz EMF exposure on micronucleus formation and apoptosis in transformed and nontransformed human cell lines. Bioelectromagnetics 19: 85-91.
32. Stich HF, Stich W and Rosin MP (1985). The micronucleus test on exfoliated human cells. Basic Life Sci. 34: 337-342.
33. Sullivan SG, Hussain R, Glasson EJ and Bittles AH (2007). The profile and incidence of cancer in Down syndrome. J. Intellect. Disabil. Res. 51: 228-231.
34. Thomas P and Fenech M (2007). A review of genome mutation and Alzheimer's disease. Mutagenesis 22: 15-33.
35. Thomas P and Fenech M (2008). Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis 23: 57-65.
36. Thomas P, Hecker J, Faunt J and Fenech M (2007). Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease. Mutagenesis 22: 371-379.
37. Thomas P, Harvey S, Gruner T and Fenech M (2008). The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls. Mutat. Res. 638: 37-47.
38. Tolbert PE, Shy CM and Allen JW (1992). Micronuclei and other nuclear anomalies in buccal smears: methods development. Mutat. Res. 271: 69-77.
39. Trippi F, Botto N, Scarpato R, Petrozzi L, et al. (2001). Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients. Mutagenesis 16: 323-327.
40. Yang J, Carmichael SL, Canfield M, Song J, et al. (2008). Socioeconomic status in relation to selected birth defects in a large multicentered US case-control study. Am. J. Epidemiol. 167: 145-154.
41. Zana M, Janka Z and Kalman J (2007). Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease. Neurobiol. Aging 28: 648-676.