DNA methylation-dependent suppression of HIF1A in an immature hematopoietic cell line HMC-1

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 1028-1032

  Walczak Drzewiecka, Aurelia ^a   Ratajewski, Marcin ^a   Pułaski, Łukasz ^a   Dastych, Jarosław ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

Author keywords

Hematopoietic cells; HIF1A; HMC 1; Methylation; Promoter

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2;

ARTICLE; BLOOD CELL; BONE MARROW; CANCER CELL CULTURE; CELL MATURATION; DNA METHYLATION; GENE EXPRESSION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION;

AZACITIDINE; CELL LINE; CELL LINE, TUMOR; DNA METHYLATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EUKARYOTA;

EID: 72949105793     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.011     Document Type: Article

References (47)

1. 2 tension. Proc. Natl. Acad. Sci. USA 92 (1995) 5510-5514
2. 2 homeostasis. Curr. Opin. Genet. Dev. 8 (1998) 588-594
3. Wiesener M.S., Munchenhagen P.M., Berger I., Morgan N.V., Roigas J., Schwiertz A., Jurgensen J.S., Gruber G., Maxwell P.H., Loning S.A., Frei U., Maher E.R., Grone H.J., and Eckardt K.U. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res. 61 (2001) 5215-5222
4. Semenza G.L., Agani F., Iyer N., Kotch L., Laughner E., Leung S., and Yu A. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Ann. NY Acad. Sci. 874 (1999) 262-268
5. Adelman D.M., Maltepe E., and Simon M.C. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 13 (1999) 2478-2483
6. Cramer T., Yamanishi Y., Clausen B.E., Forster I., Pawlinski R., Mackman N., Haase V.H., Jaenisch R., Corr M., Nizet V., Firestein G.S., Gerber H.P., Ferrara N., and Johnson R.S. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112 (2003) 645-657
7. Garcia J.A. HIFing the brakes: therapeutic opportunities for treatment of human malignancies. Sci. STKE 2006 (2006) pe24
8. Acosta-Iborra B., Elorza A., Olazabal I.M., Martin-Cofreces N.B., Martin-Puig S., Miro M., Calzada M.J., Aragones J., Sanchez-Madrid F., and Landazuri M.O. Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor. J. Immunol. 182 (2009) 3155-3164
9. Guo J., Lu W., Shimoda L.A., Semenza G.L., and Georas S.N. Enhanced interferon-gamma gene expression in T cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. Int. Arch. Allergy Immunol. 149 (2009) 98-102
10. Kong T., Eltzschig H.K., Karhausen J., Colgan S.P., and Shelley C.S. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc. Natl. Acad. Sci. USA 101 (2004) 10440-10445
11. Kirshenbaum A.S., Goff J.P., Semere T., Foster B., Scott L.M., and Metcalfe D.D. Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood 94 (1999) 2333-2342
12. Anderson D.M., Lyman S.D., Baird A., Wignall J.M., Eisenman J., Rauch C., March C.J., Boswell H.S., Gimpel S.D., Cosman D., et al. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 63 (1990) 235-243
13. Metcalfe D.D. Mast cells and mastocytosis. Blood 112 (2008) 946-956
14. Rice K.L., Hormaeche I., and Licht J.D. Epigenetic regulation of normal and malignant hematopoiesis. Oncogene 26 (2007) 6697-6714
15. Bogdanovic O., and Veenstra G.J. DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma 118 (2009) 549-565
16. Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., and Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 (1998) 386-389
17. Bockamp E.O., McLaughlin F., Murrell A.M., Gottgens B., Robb L., Begley C.G., and Green A.R. Lineage-restricted regulation of the murine SCL/TAL-1 promoter. Blood 86 (1995) 1502-1514
18. Mabaera R., Richardson C.A., Johnson K., Hsu M., Fiering S., and Lowrey C.H. Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation. Blood 110 (2007) 1343-1352
19. Lee D.U., Agarwal S., and Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16 (2002) 649-660
20. Wilson C.B., Rowell E., and Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9 (2009) 91-105
21. Kuramasu A., Saito H., Suzuki S., Watanabe T., and Ohtsu H. Mast cell-/basophil-specific transcriptional regulation of human l-histidine decarboxylase gene by CpG methylation in the promoter region. J. Biol. Chem. 273 (1998) 31607-31614
22. Lappalainen J., Lindstedt K.A., and Kovanen P.T. A protocol for generating high numbers of mature and functional human mast cells from peripheral blood. Clin. Exp. Allergy 37 (2007) 1404-1414
23. Walczak-Drzewiecka A., Ratajewski M., Wagner W., and Dastych J. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J. Immunol. 181 (2008) 1665-1672
24. Butterfield J.H., Weiler D., Dewald G., and Gleich G.J. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 12 (1988) 345-355
25. Kirshenbaum A.S., Akin C., Wu Y., Rottem M., Goff J.P., Beaven M.A., Rao V.K., and Metcalfe D.D. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 27 (2003) 677-682
26. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (2002) RESEARCH0034
27. Ratajewski M., Van de Ven W.J., Bartosz G., and Pulaski L. The human pseudoxanthoma elasticum gene ABCC6 is transcriptionally regulated by PLAG family transcription factors. Hum. Genet. 124 (2008) 451-463
28. Aranyi T., Ratajewski M., Bardoczy V., Pulaski L., Bors A., Tordai A., and Varadi A. Identification of a DNA methylation-dependent activator sequence in the Pseudoxanthoma elasticum gene, ABCC6. J. Biol. Chem. 280 (2005) 18643-18650
29. Takai D., and Jones P.A. The CpG island searcher: a new WWW resource. In Silico Biol. 3 (2003) 235-240
30. Butterfield J.H., and Weiler D.A. In vitro sensitivity of immature human mast cells to chemotherapeutic agents. Int. Arch. Allergy Appl. Immunol. 89 (1989) 297-300
31. Drexler H.G., and MacLeod R.A. Malignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia. Leuk. Res. 27 (2003) 671-676
32. Gardiner-Garden M., and Frommer M. CpG islands in vertebrate genomes. J. Mol. Biol. 196 (1987) 261-282
33. Cihak A. Biological effects of 5-azacytidine in eukaryotes. Oncology 30 (1974) 405-422
34. Stresemann C., and Lyko F. Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int. J. Cancer 123 (2008) 8-13
35. Nilsson G., Blom T., Kusche-Gullberg M., Kjellen L., Butterfield J.H., Sundstrom C., Nilsson K., and Hellman L. Phenotypic characterization of the human mast-cell line HMC-1. Scand. J. Immunol. 39 (1994) 489-498
36. Koshikawa N., Iyozumi A., Gassmann M., and Takenaga K. Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure. Oncogene 22 (2003) 6717-6724
37. Secades P., Rodrigo J.P., Hermsen M., Alvarez C., Suarez C., and Chiara M.D. Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas. Genes Chromosomes Cancer 48 (2009) 441-454
38. Parmar K., Mauch P., Vergilio J.A., Sackstein R., and Down J.D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl. Acad. Sci. USA 104 (2007) 5431-5436
39. Brunet De La Grange P., Barthe C., Lippert E., Hermitte F., Belloc F., Lacombe F., Ivanovic Z., and Praloran V. Oxygen concentration influences mRNA processing and expression of the cd34 gene. J. Cell. Biochem. 97 (2006) 135-144
40. Jantsch J., Chakravortty D., Turza N., Prechtel A.T., Buchholz B., Gerlach R.G., Volke M., Glasner J., Warnecke C., Wiesener M.S., Eckardt K.U., Steinkasserer A., Hensel M., and Willam C. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J. Immunol. 180 (2008) 4697-4705
41. Zhang J., Song L.P., Huang Y., Zhao Q., Zhao K.W., and Chen G.Q. Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica 93 (2008) 1480-1487
42. Semenza G.L. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem. Pharmacol. 59 (2000) 47-53
43. Minet E., Ernest I., Michel G., Roland I., Remacle J., Raes M., and Michiels C. HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5′UTR. Biochem. Biophys. Res. Commun. 261 (1999) 534-540
44. Wenger R.H., Rolfs A., Marti H.H., Guenet J.L., and Gassmann M. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem. Biophys. Res. Commun. 223 (1996) 54-59
45. Dehne N., and Brune B. HIF-1 in the inflammatory microenvironment. Exp. Cell Res. 315 (2009) 1791-1797
46. Antequera F. Structure, function and evolution of CpG island promoters. Cell. Mol. Life Sci. 60 (2003) 1647-1658
47. Eckhardt F., Lewin J., Cortese R., Rakyan V.K., Attwood J., Burger M., Burton J., Cox T.V., Davies R., Down T.A., Haefliger C., Horton R., Howe K., Jackson D.K., Kunde J., Koenig C., Liddle J., Niblett D., Otto T., Pettett R., Seemann S., Thompson C., West T., Rogers J., Olek A., Berlin K., and Beck S. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet. 38 (2006) 1378-1385