Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation

Blood

Volumn 110, Issue 4, 2007, Pages 1343-1352

  Mabaera, Rodwell ^a,b   Richardson, Christine A ^a,b   Johnson, Kristin ^a,b   Hsu, Mei ^a,b   Fiering, Steven ^a,b   Lowrey, Christopher H ^a,b,c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b NORRIS COTTON CANCER CENTER   (United States)

^c DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; GAMMA GLOBIN;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; ERYTHROID CELL; ERYTHROPOIESIS; FETUS LIVER; GENE CONTROL; GENE EXPRESSION; GENE SWITCHING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

EID: 34548016809     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-01-068635     Document Type: Article

References (33)

1. Papayannopoulou TH, Brice M, Stamatoyannopoulos G. Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals. Proc Natl Acad Sci U S A. 1976;73:2033-2037.
2. Fathallah H, Atweh GF. DNA hypomethylation therapy for hemoglobin disorders: molecular mechanisms and clinical applications. Blood Rev. 2006;20:227-234.
3. Perrine SP. Fetal globin induction: can it cure {beta} thalassemia? Hematology (Am Soc Hematol Educ Program). 2005;38-44.
4. Jiang YH, Bressler J, Beaudet AL. Epigenetics and human disease. Annu Rev Genomics Hum Genet. 2004;5:479-510.
5. Kransdorf EP, Wang SZ, Zhu SZ, Langston TB, Rupon JW, Ginder GD. MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood. 2006;108:2836-2845.
6. Lavelle D, Vaitkus K, Hankewych M, Singh M, DeSimone J. Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis. Blood Cells Mol Dis. 2006;36:269-278.
7. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006;103:6617-6622.
8. Ley TJ, DeSimone J, Anagnou NP, et al. 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med. 1982;307:1469-1475.
9. Dover GJ, Charache SH, Boyer SH, Talbot CC Jr, Smith KD. 5-Azacytidine increases fetal hemoglobin production in a patient with sickle cell disease. Prog Clin Biol Res. 1983;134:475-488.
10. Lowrey CH, Nienhuis AW. Brief report: treatment with azacitidine of patients with end-stage beta-thalassemia [see comments]. N Engl J Med. 1993;329:845-848.
11. Saunthararajah Y, Hillery CA, Lavelle D, et al. Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Blood. 2003;102:3865-3870.
12. Ley TJ, Anagnou NP, Noguchi CT, et al. DNA methylation and globin gene expression in patients treated with 5-azacytidine. Prog Clin Biol Res. 1983;134:457-474.
13. Jane SM, Gumucio DL, Ney PA, Cunningham JM, Nienhuis AW. Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression. Mol Cell Biol. 1993;13:3272-3281.
14. Sengupta PK, Lavelle D, DeSimone J. Increased binding of Sp1 to the gamma-globin gene promoter upon site-specific cytosine methylation. Am J Hematol. 1994;46:169-172.
15. Perrine SP, Greene MF, Cohen RA, Faller DV. A physiological delay in human fetal hemoglobin switching is associated with specific globin DNA hypomethylation. FEBS Lett. 1988;228:139-143.
16. van der Ploeg LH, Flavell RA. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell. 1980;19:947-958.
17. Mavilio F, Giampaolo A, Care A, et al. Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc Natl Acad Sci U S A. 1983;80:6907-6911.
18. Stamatoyannopoulos G. Control of globin gene expression during development and erythroid differentiation. Exp Hematol. 2005;33:259-271.
19. Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol. 1987;196:261-282.
20. Larionov A, Krause A, Miller W. A standard curve based method for relative real time PCR data processing. BMC Bioinformatics. 2005;6:62.
21. Ou CN, Rognerud CL. Rapid analysis of hemoglobin variants by cation-exchange HPLC. Clin Chem. 1993;39:820-824.
22. Fibach E, Rachmilewitz EA. A two-step liquid culture: novel culture procedure for studying erythroid cell development. Haematologia (Budap). 1991;24:211-220.
23. Wojda U, Noel P, Miller JL. Fetal and adult hemoglobin production during adult erythropoiesis: coordinate expression correlates with cell proliferation. Blood. 2002;99:3005-3013.
24. Wood WG, Weatherall DJ. Haemoglobin synthesis during human foetal development. Nature. 1973;244:162-165.
25. Lanyon WG, Ottolenghi S, Williamson R. Human globin gene expression and linkage in bone marrow and fetal liver. Proc Natl Acad Sci U S A. 1975;72:258-262.
26. Stamatoyannopoulos G, Grosveld F. Hemoglobin switching. In: Stamatoyannopoulos G, Majerus PW, Perlmutter RM, Varmus H, eds. The Molecular Basis of Blood Diseases. 3rd ed. Philadelphia, PA: W.B. Saunders; 2001:135-182.
27. deBoer E, Antoniou M, Mignotte V, Wall L, Grosveld F. The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J. 1988;7:4203-4212.
28. Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993;13:2776-2786.
29. Stamatoyannopoulos G, Veith R, Galanello R, Papayannopoulou T. Hb F production in stressed erythropoiesis: observations and kinetic models. Ann N Y Acad Sci. 1985;445:188-197.
30. Galanello R, Stamatoyannopoulos G, Papayannopoulou T. Mechanism of Hb F stimulation by S-stage compounds: in vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea. J Clin Invest. 1988;81:1209-1216.
31. DeSimone J, Biel SI, Heller P. Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia. Proc Natl Acad Sci U S A. 1978;75:2937-2940.
32. Layon ME, Ackley CJ, West RJ, Lowrey CH. Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol. 2007;366:737-744.
33. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci. 2006;31:89-97.