5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCθ: Optimization of enzymatic and functional activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 7933-7948

  Tumey, L Nathan ^a   Bhagirath, Niala ^a   Brennan, Agnes ^b   Brooijmans, Natasja ^a   Lee, Julie ^b   Yang, Xiaoke ^b   Boschelli, Diane H ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

Inflammation; Inhibitor; Kinase; PKC; PKC theta; Pyridinecarbonitrile

Indexed keywords

INTERLEUKIN 2; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; COMPUTER SIMULATION; INHIBITORY CONCENTRATION 50; ISOENZYMES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; NITRILES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 72149119244     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.020     Document Type: Article

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