The rule of five revisited: Applying log D in place of log P in drug-likeness filters

Molecular Pharmaceutics

Volumn 4, Issue 4, 2007, Pages 556-560

  Bhal, Sanjivanjit K ^a   Kassam, Karim ^a   Peirson, Ian G ^a   Pearl, Greg M ^a  

^a Advanced Chemistry Development Inc   (Canada)

Author keywords

Distribution coefficient; Drug likeness; Library screening; Lipophilicity; Log D; Log P; Oral bioavailability; Partition coefficient; Permeability; Physicochemical property prediction; Property profiling; Rule of 5

Indexed keywords

ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG INDUSTRY; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; LIPOPHILICITY; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHYSICAL; COMPUTATIONAL BIOLOGY; DRUG DESIGN; IONS; LIPIDS; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOFTWARE DESIGN; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548147556     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0700209     Document Type: Article

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