Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3623-3626

  Boschelli, Diane H ^a   Wang, Daniel ^a   Prashad, Amar S ^a   Subrath, Joan ^a   Wu, Biqi ^a   Niu, Chuan ^a   Lee, Julie ^b   Yang, Xiaoke ^b   Brennan, Agnes ^b   Chaudhary, Divya ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

3 Pyridinecarbonitrile; Kinase; PKC

Indexed keywords

5 PHENYL 3 PYRIDINECARBONITRILE DERIVATIVE; CYANIDE; PROTEIN KINASE C THETA; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ANIMALS; INDOLES; ISOENZYMES; MICE; NITRILES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66749101336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.126     Document Type: Article

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