C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCθ inhibitors: Part I

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5423-5425

  Subrath, Joan ^a   Wang, Daniel ^a   Wu, Biqi ^a   Niu, Chuansheng ^a   Boschelli, Diane H ^a   Lee, Julie ^b   Yang, Xiaoke ^b   Brennan, Agnes ^b   Chaudhary, Divya ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

PKC ; Pyridinecarbonitrile

Indexed keywords

3 PYRIDINECARBONITRILE DERIVATIVE; NITRILE; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PROTEIN KINASE C THETA INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MICE; MICE, KNOCKOUT; NITRILES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 69049107799     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.109     Document Type: Article

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18. 50 values represent the mean of at least two determinations. NT: Compound was not tested. NA: Selectivity ratio is not available.