2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 15, 2008, Pages 4420-4423

  Nathan Tumey, L ^a   Boschelli, Diane H ^a   Lee, Julie ^b   Chaudhary, Divya ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

Cyano; Indole; Inflammation; Kinase; Nitrile; PKC; PKC ; PKC ; T cell; Thienopyridine

Indexed keywords

PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PROTEIN KINASE C THETA INHIBITOR; THIENO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; INFLAMMATION; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; ISOENZYMES; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITRILES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 47949099851     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.040     Document Type: Article

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