Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonit rile PKCθ inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 766-769

  Wu, Biqi ^a   Boschelli, Diane H ^a   Lee, Julie ^b   Yang, Xiaoke ^b   Chaudhary, Divya ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

PKC ; Thieno 2,3 b pyridine 5 carbonitrile

Indexed keywords

4 (4 METHYL 1H INDOL 5 YLAMINO) 2 PHENYLTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; AMINE; HEMATOPOIETIC CELL KINASE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; IC 50; PROTEIN FAMILY;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; ISOENZYMES; MODELS, CHEMICAL; NITRILES; PROTEIN KINASE C; PYRIDINES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58849108460     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.021     Document Type: Article

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