Chemical target and pathway toxicity mechanisms defined in primary human cell systems

Journal of Pharmacological and Toxicological Methods

Volumn 61, Issue 1, 2010, Pages 3-15

  Berg, Ellen L ^a   Yang, Jian ^a   Melrose, Jennifer ^a   Nguyen, Dat ^a   Privat, Sylvie ^a   Rosler, Elen ^a   Kunkel, Eric J ^a   Ekins, Sean ^b,c,d  

^a BioSeek Inc   (United States)

^b Collaborative Drug Discovery Inc ^*  (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Cell based assay; Endothelial cell; Epithelial cell; Human; Inflammation; Mechanism of action; Microtubule; Mitochondria; Smooth muscle cell; Toxicity pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ANTIMYCIN A1; AS 602801; CALCIMYCIN; CHLORAMBUCIL; COLCHICINE; ENVIRONMENTAL CHEMICAL; ENZYME INHIBITOR; ESTRADIOL; ETACRYNIC ACID; FUMARIC ACID DIMETHYL ESTER; FUMARIC ACID ETHYL ESTER; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MYXATHIAZOL; OLIGOMYCIN; OXIDOREDUCTASE INHIBITOR; PACLITAXEL; ROTENONE; SHAOGUAMYCIN B; SODIUM AZIDE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR IX; THAPSIGARGIN; UNCLASSIFIED DRUG; VINCRISTINE; WORTMANNIN;

ARTICLE; CELL ACTIVITY; CELL ASSAY; CELL FUNCTION; CELL TYPE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLOGY; CYTOTOXICITY; DRUG DISCRIMINATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FEASIBILITY STUDY; HUMAN; HUMAN CELL; MICROTUBULE; MITOCHONDRIAL ENERGY TRANSFER; NEWBORN; PSORIASIS; REPRODUCIBILITY; TOXICITY TESTING;

BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; ENDOPLASMIC RETICULUM; ENVIRONMENTAL EXPOSURE; HUMANS; MICROTUBULES; MITOCHONDRIA; NF-KAPPA B; NOXAE; PHARMACEUTICAL PREPARATIONS; TOXICITY TESTS;

EID: 72149107842     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.10.001     Document Type: Article

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