The Korean traditional medicine Gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARα actions in rat white adipose tissues

Journal of Ethnopharmacology

Volumn 127, Issue 1, 2010, Pages 47-54

  Shin, Soon Shik ^a   Jung, Yang Sam ^a   Yoon, Ki Hyeon ^a   Choi, Seolwha ^b   Hong, Yeonhee ^b   Park, Dongmin ^b   Lee, Hyunghee ^b   Seo, Bu Il ^c   Lee, Hee Young ^a   Yoon, Michung ^b  

^a Dong Eui University   (South Korea)

^b Mokwon University   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

Adipocyte; Adiposity; Fatty acid oxidation; Gyeongshingangjeehwan; PPAR ; Visceral obesity

Indexed keywords

ANTIOBESITY AGENT; FATTY ACID BINDING PROTEIN 2; FENOFIBRATE; GYEONGSHINGANGJEEHWAN; LEPTIN; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; VERY LONG CHAIN ACYL COENZYME A DEHYDROGENASE;

ABDOMINAL OBESITY; ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPHEDRA SINICA; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; KOREA; LIPID STORAGE; LIPOHYPERTROPHY; LIRIOPE PLATYPHYLLA; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PLATYCODON GRANDIFLORUM; PROADIPOCYTE; RAT; SCHISANDRA CHINENSIS; TRADITIONAL MEDICINE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL SIZE; GENE EXPRESSION REGULATION; INTRA-ABDOMINAL FAT; LIPIDS; MALE; MEDICINE, KOREAN TRADITIONAL; MICE; OBESITY; ORGAN SIZE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PPAR ALPHA; RATS; RATS, INBRED OLETF;

ANIMALIA; RATTUS;

EID: 72149105311     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.09.052     Document Type: Article

References (45)

1. Aoyama T., Peters J.M., Iritani N., Nakajima T., Furihata K., Hashimoto T., and Gonzalez F.J. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). The Journal of Biological Chemistry 273 (1998) 5678-5684
2. Auwerx J., Schoonjans K., Fruchart J.C., and Staels B. Transcriptional control of triglyceride metabolism: fibrates and fatty acids changes the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. Atherosclerosis 124 (1996) S29-S37
3. Boozer C.N., Nasser J.A., Heymsfield S.B., Wang V., Chen G., and Solomon J.L. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Internal Journal of Obesity Related Metabolic Disorders 25 (2001) 316-324
4. Boozer C.N., Daly P.A., Homel P., Solomon J.L., Blanchard D., Nasser J.A., Strauss R., and Meredith T. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Internal Journal of Obesity Related Metabolic Disorders 26 (2002) 593-604
5. Brunzell J.D., and Hokanson J.E. Dyslipidemia of central obesity and insulin resistance. Diabetes Care 22 (1999) C10-C13
6. Bulcão C., Ferreira S.R., Giuffrida F.M., and Ribeiro-Filho F.F. The new adipose tissue and adipocytokines. Current Diabetes Reviews 2 (2006) 19-28
7. Cabrero A., Alegret M., Sánchez R.M., Adzet T., Laguna J.C., and Vázquez M. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50 (2001) 1883-1890
8. Choi S.B., Wha J.D., and Park S. The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway. Life Sciences 75 (2004) 2653-2664
9. Couillard C., Mauriege P., Imbeault P., Prud'homme D., Nadeau A., Tremblay A., Bouchard C., and Despres J.P. Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. Internal Journal of Obesity Related Metabolic Disorders 24 (2000) 782-788
10. Do E.U., Piao L.Z., Choi G., Choi Y.B., Kang T.M., Shin J., Chang Y.J., Nam H.Y., Kim H.J., and Kim S.I. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Peptides 27 (2006) 997-1004
11. Ducimetiere P., Richard J., and Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Internal Journal of Obesity Related Metabolic Disorders 10 (1986) 229-240
12. Eun J.S., Jeon Y.K., Lee K.A., Leem J.Y., Kwon J., Jang I.S., and Song J.M. Effect of Bopaewon-tang on Immune Reaction. Journal of Orient Physiology and Pathology 20 (2006) 125-130
13. Fleming R.M. Safety of ephedra and related anorexic medications. Expert Opinion on Drug Safety 7 (2008) 749-759
14. Haller C.A., and Benowitz N.L. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. The New England Journal of Medicine 343 (2000) 1833-1838
15. Haluzík M.M., and Haluzík M. PPAR-alpha and insulin sensitivity. Physiological Research 55 (2006) 115-122
16. Hertz R., Bishara-Shieban J., and Bar-Tana J. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. The Journal of Biological Chemistry 270 (1995) 13470-13475
17. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
18. Jensen M.D. Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity (Silver Spring) 14 (2006) 20S-24S
19. Jeong S., and Yoon M. Inhibition of the actions of peroxisome proliferator-activated receptor alpha on obesity by estrogen. Obesity (Silver Spring) 15 (2007) 1430-1440
20. Jeong S., Han M., Lee H., Kim M., Nicol C.J., Kim B.H., Choi J.H., Oh G.T., and Yoon M. Effects of fenofibrate on high fat diet-induced body weight gain and adiposity in female C57BL/6J mice. Metabolism 53 (2004) 1284-1289
21. Jeong S., Chae K., Jung Y.S., Rho Y.H., Lee J., Ha J., Yoon K.H., Kim G.C., Oh K.S., Shin S.S., and Yoon M. The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats. Journal of Ethnopharmacology 119 (2008) 245-251
22. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., and Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41 (1992) 1422-1428
23. Kim J. Clinical Prescriptions of Sasang Constitutional Medicine (1997), Daeseong Publishing, Seoul
24. Kissebah A.H. Central obesity: measurement and metabolic effects. Diabetes Reviews 5 (1997) 8-20
25. Kralisch S., Sommer G., Deckert C.M., Linke A., Bluher M., Stumvoll M., and Fasshauer M. Adipokines in diabetes and cardiovascular diseases. Minerva Endocrinologica 32 (2007) 161-171
26. Kroetz D.L., Yook P., Costet P., Bianchi P., and Pineau T. Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. The Journal of Biological Chemistry 273 (1998) 31581-31589
27. Lapidus L., Bengtsson C., Larsson B., Pennert K., Rybo E., and Sjöström L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. British Medical Journal (Clinical Research Ed) 289 (1984) 1257-1261
28. Lee J.M. Longevity and Life Preservation in Korean Oriental Medicine (1993), Haengnim Publishing, Seoul
29. Maffei M., Fei H., Lee G.H., Dani C., Leroy P., Zhang Y., Proenca R., Negrel R., Ailhaud G., and Friedman J.M. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proceedings of the National Academy and Sciences of the United States of America 92 (1995) 6957-6960
30. Mori Y., Nakagiri H., Kondo H., Murase T., Tokimitsu I., and Tajima N. Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Nutrition 21 (2005) 933-939
31. Murphy J.E., Zhou S., Giese K., Williams L.T., Escobedo J.A., and Dwarki V.J. Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proceedings of the National Academy and Sciences of the United States of America 94 (1997) 13921-13926
32. Nakaya Y., Ishimura N., Takishita E., and Takahashi A. Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats. Metabolism 51 (2002) 702-707
33. Okamoto Y., Higashiyama H., Inoue H., Kanematsu M., Kinoshita M., and Asano S. Quantitative image analysis in adipose tissue using an automated image analysis system: differential effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist on white and brown adipose tissue morphology in AKR obese and db/db diabetic mice. Pathology International 57 (2007) 369-377
34. Okuno A., Tamemoto H., Tobe K., Ueki K., Mori Y., Iwamoto K., Umesono K., Akanuma Y., Fujiwara T., Horikoshi H., Yazaki Y., and Kadowaki T. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. Journal of Clinical Investigation 101 (1998) 1354-1361
35. Park Y.S., Yoon Y., and Ahn H.S. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World Journal of Gastroenterology 13 (2007) 3493-3499
36. Sander K., Beatrice D., and Walter W. Roles of PPARs in health and disease. Nature 405 (2000) 421-424
37. Shen W., Wang Z., Punyanita M., Lei J., Sinav A., Kral J.G., Imielinska C., Ross R., and Heymsfield S.B. Adipose tissue quantification by imaging methods: a proposed classification. Obesity Research 11 (2003) 5-16
38. Spiegelman B.M., and Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell 87 (1996) 377-389
39. Tchernof A. Visceral adipocytes and the metabolic syndrome. Nutrition Reviews 65 (2007) S24-S29
40. Vázquez M., Roglans N., Cabrero A., Rodríguez C., Adzet T., Alegret M., Sánchez R.M., and Laguna J.C. Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue. Molecular and Cellular Biochemistry 216 (2001) 71-78
41. Wickelgren I. Obesity: how big a problem?. Science 280 (1998) 1364-1367
42. Yan Z.H., Karam W.G., Staudinger J.L., Medvedev A., Ghanayem B.I., and Jetten A.M. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. The Journal of Biological Chemistry 273 (1998) 10948-10957
43. Yao H.T., Chang Y.W., Chen C.T., Chiang M.T., Chang L., and Yeh T.K. Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet. Journal of Ethnopharmacology 116 (2008) 49-57
44. Yoon M., Jeong S., Lee H., Han M., Kang J.H., Kim E.Y., Kim M., and Oh G.T. Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice. Biochemical and Biophysical Research Communications 302 (2003) 29-34
45. Zheng J., He J., Ji B., Li Y., and Zhang X. Antihyperglycemic effects of Platycodon grandiflorum (Jacq.) A. DC. extract on streptozotocin-induced diabetic mice. Plant Foods for Human Nutrition 62 (2007) 7-11