The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Journal of Ethnopharmacology

Volumn 119, Issue 2, 2008, Pages 245-251

  Jeong, Sunhyo ^a   Chae, Kyungsil ^a   Jung, Yang Sam ^b   Rho, Young Ho ^b   Lee, Jinmi ^a   Ha, Juran ^a   Yoon, Ki Hyeon ^b   Kim, Gyeong Cheol ^b   Oh, Ki Sook ^c   Shin, Soon Shik ^b   Yoon, Michung ^a  

^a Mokwon University   (South Korea)

^b Dong Eui University   (South Korea)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Appetite; Gyeongshingangjeehwan; Hypertriglyceridemia; Leptin; Obesity; OLETF rat; PPAR

Indexed keywords

ANTIOBESITY AGENT; EPHEDRA SINICA EXTRACT; GYEONGSHINGANGJEEHWAN; HERBACEOUS AGENT; LEPTIN; LIRIOPE PLATYPHYLLA EXTRACT; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; PLATYCODON GRANDIFLORUM EXTRACT; SCHISANDRA CHINENSIS EXTRACT; SIBUTRAMINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ABDOMINAL FAT; ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG DOSE COMPARISON; EPHEDRA SINICA; FOOD INTAKE; FRUIT; GENE EXPRESSION REGULATION; HORMONE BLOOD LEVEL; HYPERTRIGLYCERIDEMIA; KOREA; LIPID METABOLISM; LIRIOPE PLATYPHYLLA; LIVER CELL; LIVER METABOLISM; MALE; MEDICINAL PLANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; ORIENTAL MEDICINE; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PLANT ROOT; PLANT STEM; PLATYCODON; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISANDRACEAE; TRADITIONAL MEDICINE; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

ABDOMINAL FAT; ANIMALS; ANTI-OBESITY AGENTS; CELL LINE; EATING; GENE EXPRESSION REGULATION; GENES, REPORTER; LEPTIN; LIVER; MALE; MEDICINE, KOREAN TRADITIONAL; MICE; OBESITY; PLANTS, MEDICINAL; PPAR ALPHA; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; RNA, MESSENGER; TRIGLYCERIDES; WEIGHT GAIN;

CAMPANULACEAE; EPHEDRA SINICA; EPHEDRACEAE; LILIACEAE; LIRIOPE PLATYPHYLLA; MAGNOLIACEAE; PLATYCODON GRANDIFLORUM; RATTUS; SCHISANDRA CHINENSIS;

EID: 50949084007     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.06.037     Document Type: Article

References (39)

1. Ahima R.S., and Flier J.S. Leptin. Annual Review of Physiology 62 (2000) 413-437
2. Barkeling B., Elfhag K., Rooth P., and Rössner S. Short-term effects of sibutramine (Reductil) on appetite and eating behaviour and the long-term therapeutic outcome. International Journal of Obesity and Related Metabolic Disorders 27 (2003) 693-700
3. Bourgeois F., Alexiu A., and Lemonnier D. Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice. The British Journal of Nutrition 49 (1983) 17-26
4. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334 (1996) 292-295
5. Chaput E., Saladin R., Silvestre M., and Edgar A.D. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochemical and Biophysical Research Communications 271 (2000) 445-450
6. Costet P., Legendre C., More J., Edgar A., Galtier P., and Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. The Journal of Biological Chemistry 273 (1998) 29577-29585
7. Das D.K., and Maulik N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Molecular Interventions 6 (2006) 36-47
8. Erol A. PPARalpha activators may be good candidates as antiaging agents. Medical Hypotheses 65 (2005) 35-38
9. Erol A. The functions of PPARs in aging and longevity. PPAR Research 2007 (2007) 1-10
10. Eun J.S., Jeon Y.K., Lee K.A., Leem J.Y., Kwon J., Jang I.S., and Song J.M. Effect of Bopaewon-tang on Immune Reaction. Journal of Orient Physiology and Pathology 20 (2006) 125-130
11. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
12. Guerre-Millo M., Gervois P., Raspe E., Madsen L., Poulain P., Derudas B., Herbert J.M., Winegar D.A., Willson T.M., Fruchart J.C., Berge R.K., and Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. The Journal of Biological Chemistry 275 (2000) 16638-16642
13. Hajnal A., Covasa M., and Bello N.T. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289 (2005) R1675-R1686
14. Hidaka S., Ogawa Y., Ebihara K., Shintani M., Abe M., Miyanaga F., and Nakao K. Pathology and significance of leptin resistance in obesity Nippon Rinsho. Japanese Journal Clinical Medicine 59 (2001) 472-480
15. Holden P.R., and Tugwood J.D. Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences. Journal of Molecular Endocrinology 22 (1999) 1-8
16. Jeong S., Han M., Lee H., Kim M., Nicol C.J., Kim B.H., Choi J.H., Oh G.T., and Yoon M. Effects of fenofibrate on high fat diet-induced body weight gain and adiposity in female C57BL/6J mice. Metabolism 53 (2004) 1284-1289
17. Jeong S., Kim M., Han M., Lee H., Ahn J., Kim M., Song Y.H., Shin C., Nam K.H., Kim T.W., Oh G.T., and Yoon M. Fenofibrate prevents obesity and hypertriglyceridemia in LDL receptor-null mice. Metabolism 53 (2004) 607-613
18. Kim J. Clinical Prescriptions of Sasang Constitutional Medicine (1997), Daeseong Publishing, Seoul
19. Lee J.M. Longevity and Life Preservation in Korean Oriental Medicine (1993), Haengnim Publishing, Seoul
20. Liang C.P., and Tall A.R. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. The Journal of Biological Chemistry 276 (2001) 49066-49076
21. Maffei M., Fei H., Lee G.H., Dani C., Leroy P., Zhang Y., Proenca R., Negrel R., Ailhaud G., and Friedman J.M. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proceedings of the National Academy and Sciences of the United States of America 92 (1995) 6957-6960
22. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1 (1995) 1155-1161
23. Mancini F.P., Lanni A., Sabatino L., Moreno M., Giannino A., Contaldo F., Colantuoni V., and Goglia F. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Letters 491 (2001) 154-158
24. Moran T.H., Katz L.F., Plata-Salaman C.R., and Schwartz G.J. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274 (1998) R618-R625
25. Mori Y., Nakagiri H., Kondo H., Murase T., Tokimitsu I., and Tajima N. Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Nutrition 21 (2005) 933-939
26. Muoio D.M., and Lynis Dohm G. Peripheral metabolic actions of leptin. Best practice & research. Clinical Endocrinology and Metabolism 16 (2002) 653-666
27. Nakaya Y., Ishimura N., Takishita E., and Takahashi A. Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats. Metabolism 51 (2002) 702-707
28. Park Y.S., Yoon Y., and Ahn H.S. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World Journal of Gastroenterology 13 (2007) 3493-3499
29. Sattar N., Packard C.J., and Petrie J.R. The end of triglycerides in cardiovascular risk assessment? Rumours of death are greatly exaggerated. British Medical Journal 317 (1998) 553-554
30. Sharpe P.A., Blanck H.M., Williams J.E., Ainsworth B.E., and Conway J.M. Use of complementary and alternative medicine for weight control in the United States. Journal of Alternative and Complementary Medicine (New York, NY) 13 (2007) 217-222
31. Suzuki A., Okamoto S., Lee S., Saito K., Shiuchi T., and Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Molecular and Cellular Biology 27 (2007) 4317-4327
32. Valcheva-Kuzmanova S., Kuzmanov K., Tancheva S., and Belcheva A. Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods and Findings in Experimental and Clinical Pharmacology 29 (2007) 101-105
33. Wilson T.M., Brown P.J., Sternbach D.D., and Henke B.R. PPARs: from orphan receptors to drug discovery. Journal of Medicinal Chemistry 43 (2000) 527-550
34. Yao H.T., Chang Y.W., Chen C.T., Chiang M.T., Chang L., and Yeh T.K. Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet. Journal of Ethnopharmacology 116 (2008) 49-57
35. Ye P., Wang Z.J., Zhang X.J., and Zhao Y.L. Age-related decrease in expression of peroxisome proliferator-activated receptor α and its effects on development of dyslipidemia. Chinese Medical Journal 118 (2005) 1093-1098
36. Yoon M., Jeong S., Nicol C.J., Lee H., Han M., Kim J.J., Seo Y.J., Ryu C., and Oh G.T. Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism. Experimental and Molecular Medicine 34 (2002) 485-492
37. Yoon M., Jeong S., Lee H., Han M., Kang J.H., Kim E.Y., Kim M., and Oh G.T. Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice. Biochemical and Biophysical Research Communications 302 (2003) 29-34
38. Zheng J., He J., Ji B., Li Y., and Zhang X. Antihyperglycemic effects of Platycodon grandiflorum (Jacq) A. DC. extract on streptozotocin-induced diabetic mice. Plant Foods for Human Nutrition 62 (2007) 7-11
39. Zimmet P., Boyko E.J., Collier G.R., and de Courten M. Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players. Annals of the New York Academy of Sciences 892 (1999) 25-44