Quantitative image analysis in adipose tissue using an automated image analysis system: Differential effects of peroxisome proliferator-activated receptor-α and -γ agonist on white and brown adipose tissue morphology in AKR obese and db/db diabetic mice

Pathology International

Volumn 57, Issue 6, 2007, Pages 369-377

  Okamoto, Yuji ^a   Higashiyama, Hiroyuki ^a   Inoue, Hiroki ^a   Kanematsu, Masahiro ^a   Kinoshita, Mine ^a   Asano, Satoshi ^a  

^a Development and Medical Affairs Division   (Japan)

Author keywords

Brown adipose tissue; Diabetes; Morphometry; Obesity; PPAR; White adipose tissue

Indexed keywords

GI 259578A; GW 347845X; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; BROWN ADIPOSE TISSUE; CELL SIZE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; IMAGE ANALYSIS; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; WHITE ADIPOSE TISSUE;

ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ANIMALS; CELL SIZE; DIABETES MELLITUS, TYPE 2; HYPOGLYCEMIC AGENTS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PPAR ALPHA; PPAR GAMMA;

EID: 34249791221     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2007.02109.x     Document Type: Article

References (35)

1. Yamauchi T, Kamon J, Waki H et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 2001 276 : 41 45 54.
2. Kubota N, Terauchi Y, Miki H et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999 4 : 597 609.
3. Jimenez M, Barbatelli G, Allevi R et al. Beta 3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat. Eur J Biochem 2003 270 : 699 705.
4. Okuno A, Tamemoto H, Tobe K et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 1998 101 : 1354 61.
5. Yamauchi T, Waki H, Kamon J et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 2001 108 : 1001 13.
6. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 1993 259 : 87 91.
7. Maffei M, Fei H, Lee GH et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995 92 : 6957 60.
8. Pedersen O, Kahn CR, Kahn BB. Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. J Clin Invest 1992 89 : 1964 73.
9. Cannon B, Nedergaard J. The biochemistry of an inefficient tissue: Brown adipose tissue. Essays Biochem 1985 20 : 110 64.
10. Himms-Hagen J. Brown adipose tissue thermogenesis: Interdisciplinary studies. FASEB J 1990 4 : 2890 98.
11. Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Obes Res 1997 5 : 650 56.
12. Ricquier D, Bouillaud F. Mitochondrial uncoupling proteins: From mitochondria to the regulation of energy balance. J Physiol 2000 529 (Pt 1 3 10.
13. Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004 10 : 355 61.
14. Patsouris D, Muller M, Kersten S. Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance. Curr Opin Invest Drugs 2004 5 : 1045 50.
15. Reddy JK, Hashimoto T. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system. Annu Rev Nutr 2001 21 : 193 230.
16. Gorla-Bajszczak A, Siegrist-Kaiser C, Boss O, Burger AG, Meier CA. Expression of peroxisome proliferator-activated receptors in lean and obese Zucker rats. Eur J Endocrinol 2000 142 : 71 8.
17. Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002 53 : 409 35.
18. Rosen ED, Spiegelman BM. PPARgamma: A nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001 276 : 37731 4.
19. Ghorbani M, Claus TH, Himms-Hagen J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochem Pharmacol 1997 54 : 121 31.
20. Tsuchida A, Yamauchi T, Takekawa S et al. Peroxisome proliferator- activated receptor (PPAR)α activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: Comparison of activation of PPARα, PPARλ, and their combination. Diabetes 2005 54 : 3358 70.
21. Gervois P, Fruchart JC, Staels B. Inflammation, dyslipidaemia, diabetes and PPARs: Pharmacological interest of dual PPARα and PPARλ agonists. Int J Clin Pract Suppl 2004 143 : 22 9.
22. Larsen PJ, Jensen PB, Sorensen RV et al. Differential influences of peroxisome proliferator-activated receptors gamma and alpha on food intake and energy homeostasis. Diabetes 2003 52 : 2249 59.
23. Verreth W, De Keyzer D, Pelat M et al. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 2004 110 : 3259 69.
24. Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 2005 54 : 2460 70.
25. Pineda TI, Gervois P, Staels B. Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging. Curr Opin Lipidol 1999 10 : 151 9.
26. Spiegelman BM. Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity. Eur J Med Res 1997 2 : 457 64.
27. Gulick T, Cresci S, Caira T, Moore DD, Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 1994 91 : 11 12 16.
28. Chou CJ, Haluzik M, Gregory C et al. WY14 6 43, a peroxisome proliferator-activated receptor alpha (PPARα) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem 2002 277 : 24 84 9.
29. Kim H, Haluzik M, Asghar Z et al. Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes 2003 52 : 1770 78.
30. Vazquez M, Roglans N, Cabrero A et al. Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue. Mol Cell Biochem 2001 216 : 71 8.
31. Cabrero A, Alegret M, Sanchez RM, Adzet T, Laguna JC, Vazquez M. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 2001 50 : 1883 90.
32. Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med 2002 8 : 1122 8.
33. Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998 273 : 16 10 14.
34. Rocchi S, Auwerx J. Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription. Br J Nutr 2000 84 : S223 7.
35. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000 14 : 1293 307.