Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives

Journal of Medicinal Chemistry

Volumn 49, Issue 15, 2006, Pages 4512-4516

  Smits, Rogier A ^a   Lim, Herman D ^a   Stegink, Bart ^a   Bakker, Remko A ^a   De Esch, Iwan J P ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 11 (4 METHYLPIPERAZIN 1 YL)DIBENZO[B,F][1,4]OXAZEPINE; ANTIHISTAMINIC AGENT; BENZODIAZEPINE DERIVATIVE; CLOZAPINE; DIBENZODIAZEPINE DERIVATIVE; HISTAMINE; HISTAMINE H4 RECEPTOR; IMIDAZOLE DERIVATIVE; JNJ 7777120; TRITIUM; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; LIGAND;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PHARMACOLOGY; PHARMACOPHORE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CELL LINE; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; METABOLISM; RADIOASSAY; STEREOISOMERISM; SYNTHESIS;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; HUMANS; LIGANDS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746725305     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051008s     Document Type: Article

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