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Volumn 90, Issue 1, 2010, Pages 60-68

Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation

Author keywords

Adult neurogenesis; Cognitive dysfunction; Dentate gyrus; Melatonin; Radiation

Indexed keywords

AGOMELATINE; ALPHA TOCOPHEROL; ASCORBIC ACID; CURCUMIN; FREE RADICAL; MELATONIN; MITOCHONDRIAL DNA; PLACEBO; QUERCETIN; REACTIVE OXYGEN METABOLITE;

EID: 72049087712     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2009.10.019     Document Type: Review
Times cited : (85)

References (149)
  • 1
    • 10344263377 scopus 로고    scopus 로고
    • Pathogenesis of irradiation-induced cognitive dysfunction
    • Abayomi O.K. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 35 (1996) 659-663
    • (1996) Acta Oncol. , vol.35 , pp. 659-663
    • Abayomi, O.K.1
  • 2
    • 0036352612 scopus 로고    scopus 로고
    • Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors
    • Abayomi O.K. Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors. Acta Oncol. 41 (2002) 346-351
    • (2002) Acta Oncol. , vol.41 , pp. 346-351
    • Abayomi, O.K.1
  • 3
    • 0037171033 scopus 로고    scopus 로고
    • Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells
    • Armstrong K.J., and Niles L.P. Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells. Neuroreport 13 (2002) 473-475
    • (2002) Neuroreport , vol.13 , pp. 473-475
    • Armstrong, K.J.1    Niles, L.P.2
  • 5
    • 33744919791 scopus 로고    scopus 로고
    • Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
    • Banasr M., Soumier A., Hery M., Mocaer E., and Daszuta A. Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis. Biol. Psychiatry. 59 (2006) 1087-1096
    • (2006) Biol. Psychiatry. , vol.59 , pp. 1087-1096
    • Banasr, M.1    Soumier, A.2    Hery, M.3    Mocaer, E.4    Daszuta, A.5
  • 6
    • 11844275306 scopus 로고    scopus 로고
    • Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death
    • Bao J.F., Wu R.G., Zhang X.P., Song Y., and Li C.L. Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death. Acta Pharmacol. Sin. 26 (2005) 117-123
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 117-123
    • Bao, J.F.1    Wu, R.G.2    Zhang, X.P.3    Song, Y.4    Li, C.L.5
  • 7
    • 0014218466 scopus 로고
    • Acute pharmacology of melatonin
    • Barchas J., DaCosta F., and Spector S. Acute pharmacology of melatonin. Nature 214 (1967) 919-920
    • (1967) Nature , vol.214 , pp. 919-920
    • Barchas, J.1    DaCosta, F.2    Spector, S.3
  • 8
    • 0000163631 scopus 로고
    • The chemical consequences of radiation damage to DNA
    • Becker D., and Sevilla M.D. The chemical consequences of radiation damage to DNA. Adv. Radiat. Biol. 17 (1993) 121-179
    • (1993) Adv. Radiat. Biol. , vol.17 , pp. 121-179
    • Becker, D.1    Sevilla, M.D.2
  • 10
    • 0034986704 scopus 로고    scopus 로고
    • Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells
    • Benitez-King G., Hernandez M.E., Tovar R., and Ramirez G. Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells. Neurochem. Int. 39 (2001) 95-102
    • (2001) Neurochem. Int. , vol.39 , pp. 95-102
    • Benitez-King, G.1    Hernandez, M.E.2    Tovar, R.3    Ramirez, G.4
  • 11
    • 0029145084 scopus 로고
    • Are reactive oxygen species involved in Alzheimer's disease?
    • Benzi G., and Moretti A. Are reactive oxygen species involved in Alzheimer's disease?. Neurobiol. Aging 16 (1995) 661-674
    • (1995) Neurobiol. Aging , vol.16 , pp. 661-674
    • Benzi, G.1    Moretti, A.2
  • 14
    • 33644772082 scopus 로고    scopus 로고
    • Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice
    • Chen T.Y., Lee M.Y., Chen H.Y., Kuo Y.L., Lin S.C., Wu T.S., and Lee E.J. Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice. J. Pineal Res. 40 (2006) 242-250
    • (2006) J. Pineal Res. , vol.40 , pp. 242-250
    • Chen, T.Y.1    Lee, M.Y.2    Chen, H.Y.3    Kuo, Y.L.4    Lin, S.C.5    Wu, T.S.6    Lee, E.J.7
  • 15
    • 34447577880 scopus 로고    scopus 로고
    • Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells
    • Chetsawang J., Govitrapong P., and Chetsawang B. Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells. J. Pineal Res. 43 (2007) 115-120
    • (2007) J. Pineal Res. , vol.43 , pp. 115-120
    • Chetsawang, J.1    Govitrapong, P.2    Chetsawang, B.3
  • 16
    • 0037378182 scopus 로고    scopus 로고
    • The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion
    • Cheung R.T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J. Pineal Res. 34 (2003) 153-160
    • (2003) J. Pineal Res. , vol.34 , pp. 153-160
    • Cheung, R.T.1
  • 17
    • 0023227843 scopus 로고
    • Separable roles of hippocampal granule cells in forgetting and pyramidal cells in remembering spatial information
    • Collier T.J., Quirk G.J., and Routtenberg A. Separable roles of hippocampal granule cells in forgetting and pyramidal cells in remembering spatial information. Brain Res. 409 (1987) 316-328
    • (1987) Brain Res. , vol.409 , pp. 316-328
    • Collier, T.J.1    Quirk, G.J.2    Routtenberg, A.3
  • 18
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle J.T., and Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262 (1993) 689-695
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 20
    • 0035943414 scopus 로고    scopus 로고
    • Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury
    • Cuzzocrea S., and Reiter R.J. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur. J. Pharmacol. 426 (2001) 1-10
    • (2001) Eur. J. Pharmacol. , vol.426 , pp. 1-10
    • Cuzzocrea, S.1    Reiter, R.J.2
  • 21
    • 0036178170 scopus 로고    scopus 로고
    • In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats
    • Dantas A.P., Tostes R.C., Fortes Z.B., Costa S.G., Nigro D., and Carvalho M.H. In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats. Hypertension 39 (2002) 405-411
    • (2002) Hypertension , vol.39 , pp. 405-411
    • Dantas, A.P.1    Tostes, R.C.2    Fortes, Z.B.3    Costa, S.G.4    Nigro, D.5    Carvalho, M.H.6
  • 22
    • 49549085247 scopus 로고    scopus 로고
    • Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress
    • Das A., Belagodu A., Reiter R.J., Ray S.K., and Banik N.L. Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. J. Pineal Res. 45 (2008) 117-124
    • (2008) J. Pineal Res. , vol.45 , pp. 117-124
    • Das, A.1    Belagodu, A.2    Reiter, R.J.3    Ray, S.K.4    Banik, N.L.5
  • 23
    • 0035866067 scopus 로고    scopus 로고
    • Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury
    • Dash P.K., Mach S.A., and Moore A.N. Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury. J. Neurosci. Res. 63 (2001) 313-319
    • (2001) J. Neurosci. Res. , vol.63 , pp. 313-319
    • Dash, P.K.1    Mach, S.A.2    Moore, A.N.3
  • 25
    • 36248957048 scopus 로고    scopus 로고
    • Melatonin receptors: role on sleep and circadian rhythm regulation
    • Dubocovich M.L. Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med. 8 Suppl. 3 (2007) 34-42
    • (2007) Sleep Med. , vol.8 , Issue.SUPPL. 3 , pp. 34-42
    • Dubocovich, M.L.1
  • 26
    • 23744445174 scopus 로고    scopus 로고
    • Effect of MT1 melatonin receptor deletion on melatoninmediated phase shift of circadian rhythms in the C57BL/6 mouse
    • Dubocovich M.L., Hudson R.L., Sumaya I.C., Masana M.I., and Manna E. Effect of MT1 melatonin receptor deletion on melatoninmediated phase shift of circadian rhythms in the C57BL/6 mouse. J. Pineal Res. 39 (2005) 113-120
    • (2005) J. Pineal Res. , vol.39 , pp. 113-120
    • Dubocovich, M.L.1    Hudson, R.L.2    Sumaya, I.C.3    Masana, M.I.4    Manna, E.5
  • 29
    • 7444227078 scopus 로고    scopus 로고
    • Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells
    • Feng Z., and Zhang J.T. Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells. J. Pineal Res. 37 (2004) 257-266
    • (2004) J. Pineal Res. , vol.37 , pp. 257-266
    • Feng, Z.1    Zhang, J.T.2
  • 30
    • 0026647763 scopus 로고
    • Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd R.A., and Carney J.M. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32 (1992) S22-S27
    • (1992) Ann. Neurol. , vol.32
    • Floyd, R.A.1    Carney, J.M.2
  • 32
    • 59149092032 scopus 로고    scopus 로고
    • Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin
    • Gitto E., Pellegrino S., Gitto P., Barberi I., and Reiter R.J. Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. J. Pineal Res. 46 (2009) 128-139
    • (2009) J. Pineal Res. , vol.46 , pp. 128-139
    • Gitto, E.1    Pellegrino, S.2    Gitto, P.3    Barberi, I.4    Reiter, R.J.5
  • 33
    • 0033363319 scopus 로고    scopus 로고
    • Learning enhances adult neurogenesis in the hippocampal formation
    • Gould E., Beylin A., Tanapat P., Reeves A., and Shors T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2 (1999) 260-265
    • (1999) Nat. Neurosci. , vol.2 , pp. 260-265
    • Gould, E.1    Beylin, A.2    Tanapat, P.3    Reeves, A.4    Shors, T.J.5
  • 37
    • 41449101754 scopus 로고    scopus 로고
    • Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat
    • Guzman-Marin R., Suntsova N., Bashir T., Nienhuis R., Szymusiak R., and McGinty D. Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat. Sleep 31 (2008) 167-175
    • (2008) Sleep , vol.31 , pp. 167-175
    • Guzman-Marin, R.1    Suntsova, N.2    Bashir, T.3    Nienhuis, R.4    Szymusiak, R.5    McGinty, D.6
  • 38
    • 0025069762 scopus 로고
    • How to characterize a biological antioxidant
    • Halliwell B. How to characterize a biological antioxidant. Free Rad. Res. Commun. 9 (1990) 1-32
    • (1990) Free Rad. Res. Commun. , vol.9 , pp. 1-32
    • Halliwell, B.1
  • 39
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now?
    • Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 97 (2006) 1634-1658
    • (2006) J. Neurochem. , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 40
    • 0023110837 scopus 로고
    • Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorus acid by ascorbic acid
    • Halliwell B., Wasil M., and Grootvels M. Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorus acid by ascorbic acid. FEBS Lett. 213 (1987) 15-17
    • (1987) FEBS Lett. , vol.213 , pp. 15-17
    • Halliwell, B.1    Wasil, M.2    Grootvels, M.3
  • 41
    • 0025972738 scopus 로고
    • DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems
    • Halliwell B., and Aruoma O.I. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett. 281 (1991) 9-19
    • (1991) FEBS Lett. , vol.281 , pp. 9-19
    • Halliwell, B.1    Aruoma, O.I.2
  • 42
    • 46449116418 scopus 로고    scopus 로고
    • Melatonin, hormone of darkness and more-occurrence, control mechanisms, actions and bioactive metabolites
    • Hardeland R. Melatonin, hormone of darkness and more-occurrence, control mechanisms, actions and bioactive metabolites. Cell. Mol. Life Sci. 65 (2008) 2001-2018
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 2001-2018
    • Hardeland, R.1
  • 44
    • 1842426537 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects
    • Holmes M.M., Galea L.A., Mistlberger R.E., and Kempermann G. Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects. J. Neurosci. Res. 76 (2004) 216-222
    • (2004) J. Neurosci. Res. , vol.76 , pp. 216-222
    • Holmes, M.M.1    Galea, L.A.2    Mistlberger, R.E.3    Kempermann, G.4
  • 45
    • 0030569251 scopus 로고    scopus 로고
    • Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells
    • Ikushima T., Aritomi H., and Morisita J. Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells. Mutat. Res. 358 (1996) 193-198
    • (1996) Mutat. Res. , vol.358 , pp. 193-198
    • Ikushima, T.1    Aritomi, H.2    Morisita, J.3
  • 46
    • 0344069780 scopus 로고    scopus 로고
    • Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
    • Jahnke G., Marr M., Myers C., Wilson R., Travlos G., and Price C. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol. Sci. 50 (1999) 271-279
    • (1999) Toxicol. Sci. , vol.50 , pp. 271-279
    • Jahnke, G.1    Marr, M.2    Myers, C.3    Wilson, R.4    Travlos, G.5    Price, C.6
  • 47
    • 33845545775 scopus 로고    scopus 로고
    • Evidence supporting the use of melatonin in short gestation infants
    • Jan J.E., Wasdell M.B., Freeman R.D., and Bax M. Evidence supporting the use of melatonin in short gestation infants. J. Pineal Res. 42 (2007) 22-27
    • (2007) J. Pineal Res. , vol.42 , pp. 22-27
    • Jan, J.E.1    Wasdell, M.B.2    Freeman, R.D.3    Bax, M.4
  • 48
    • 34848919892 scopus 로고    scopus 로고
    • Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis
    • Jou M.J., Peng T.I., Yu P.Z., Reiter R.J., Chen J.Y., Wu H.Y., Chen C.C., and Hsu L.F. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J. Pineal Res. 43 (2007) 389-403
    • (2007) J. Pineal Res. , vol.43 , pp. 389-403
    • Jou, M.J.1    Peng, T.I.2    Yu, P.Z.3    Reiter, R.J.4    Chen, J.Y.5    Wu, H.Y.6    Chen, C.C.7    Hsu, L.F.8
  • 49
    • 0037394420 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
    • Kalivendi S.V., Kotamraju S., Cunningham S., Shang T., Hillard C.J., and Kalyanaraman B. 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. Biochem. J. 371 (2003) 151-164
    • (2003) Biochem. J. , vol.371 , pp. 151-164
    • Kalivendi, S.V.1    Kotamraju, S.2    Cunningham, S.3    Shang, T.4    Hillard, C.J.5    Kalyanaraman, B.6
  • 51
    • 0033002666 scopus 로고    scopus 로고
    • The effect of melatonin on lipid peroxidation during radiotherapy in female rats
    • Kaya H., Delibas N., Serteser M., Ulukaya E., and Ozkaya O. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlenther. Onkol. 175 (1999) 285-288
    • (1999) Strahlenther. Onkol. , vol.175 , pp. 285-288
    • Kaya, H.1    Delibas, N.2    Serteser, M.3    Ulukaya, E.4    Ozkaya, O.5
  • 53
    • 41249099823 scopus 로고    scopus 로고
    • The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
    • Kempermann G. The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?. Trends Neurosci. 31 (2008) 163-169
    • (2008) Trends Neurosci. , vol.31 , pp. 163-169
    • Kempermann, G.1
  • 54
    • 47349084792 scopus 로고    scopus 로고
    • Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice
    • Kilic E., Kilic U., Bacigaluppi M., Guo Z., Abdallah N.B., Wolfer D.P., Reiter R.J., Hermann D.M., and Bassetti C.L. Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice. J. Pineal Res. 45 (2008) 142-148
    • (2008) J. Pineal Res. , vol.45 , pp. 142-148
    • Kilic, E.1    Kilic, U.2    Bacigaluppi, M.3    Guo, Z.4    Abdallah, N.B.5    Wolfer, D.P.6    Reiter, R.J.7    Hermann, D.M.8    Bassetti, C.L.9
  • 55
    • 52249094171 scopus 로고    scopus 로고
    • Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis
    • Kim J.S., Lee H.J., Kim J.C., Kang S.S., Bae C.S., Shin T., Jin J.K., Kim S.H., Wang H., and Moon C. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J. Radiat. Res. (Tokyo) 49 (2008) 517-526
    • (2008) J. Radiat. Res. (Tokyo) , vol.49 , pp. 517-526
    • Kim, J.S.1    Lee, H.J.2    Kim, J.C.3    Kang, S.S.4    Bae, C.S.5    Shin, T.6    Jin, J.K.7    Kim, S.H.8    Wang, H.9    Moon, C.10
  • 56
    • 4644268521 scopus 로고    scopus 로고
    • Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats
    • Kim M.J., Kim H.K., Kim B.S., and Yim S.V. Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats. J. Pineal Res. 37 (2004) 193-197
    • (2004) J. Pineal Res. , vol.37 , pp. 193-197
    • Kim, M.J.1    Kim, H.K.2    Kim, B.S.3    Yim, S.V.4
  • 57
    • 36849017964 scopus 로고    scopus 로고
    • Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3
    • Koh P.O. Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. J. Pineal Res. 44 (2008) 101-106
    • (2008) J. Pineal Res. , vol.44 , pp. 101-106
    • Koh, P.O.1
  • 58
    • 43049123138 scopus 로고    scopus 로고
    • Melatonin regulates the viability and differentiation of rat midbrain neural stem cells
    • Kong X., Li X., Cai Z., Yang N., Liu Y., Shu J., Pan L., and Zuo P. Melatonin regulates the viability and differentiation of rat midbrain neural stem cells. Cell. Mol. Neurobiol. 28 (2008) 569-579
    • (2008) Cell. Mol. Neurobiol. , vol.28 , pp. 569-579
    • Kong, X.1    Li, X.2    Cai, Z.3    Yang, N.4    Liu, Y.5    Shu, J.6    Pan, L.7    Zuo, P.8
  • 59
    • 0022388062 scopus 로고
    • Pharmacokinetics of melatonin in man: first pass hepatic metabolism
    • Lane E.A., and Moss H.B. Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J. Clin. Endocrinol. Metab. 61 (1985) 1214-1216
    • (1985) J. Clin. Endocrinol. Metab. , vol.61 , pp. 1214-1216
    • Lane, E.A.1    Moss, H.B.2
  • 60
    • 33644908054 scopus 로고    scopus 로고
    • Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus
    • Lee S.H., Chun W., Kong P.J., Han J.A., Cho B.P., Kwon O.Y., Lee H.J., and Kim S.S. Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus. J. Pineal Res. 40 (2006) 79-85
    • (2006) J. Pineal Res. , vol.40 , pp. 79-85
    • Lee, S.H.1    Chun, W.2    Kong, P.J.3    Han, J.A.4    Cho, B.P.5    Kwon, O.Y.6    Lee, H.J.7    Kim, S.S.8
  • 61
    • 0035874967 scopus 로고    scopus 로고
    • Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins
    • Lee S.H., Oe T., and Blair I.A. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 292 (2001) 2083-2086
    • (2001) Science , vol.292 , pp. 2083-2086
    • Lee, S.H.1    Oe, T.2    Blair, I.A.3
  • 62
    • 0347995022 scopus 로고    scopus 로고
    • Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress
    • Limoli C.L., Giedzinski E., Rola R., Otsuka S., Palmer T.D., and Fike J.R. Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat. Res. 161 (2004) 17-27
    • (2004) Radiat. Res. , vol.161 , pp. 17-27
    • Limoli, C.L.1    Giedzinski, E.2    Rola, R.3    Otsuka, S.4    Palmer, T.D.5    Fike, J.R.6
  • 64
    • 33750078110 scopus 로고    scopus 로고
    • Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stress
    • Limoli C.L., Giedzinski E., Baure J., Rola R., and Fike J.R. Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stress. Int. J. Radiat. Biol. 82 (2006) 640-647
    • (2006) Int. J. Radiat. Biol. , vol.82 , pp. 640-647
    • Limoli, C.L.1    Giedzinski, E.2    Baure, J.3    Rola, R.4    Fike, J.R.5
  • 66
    • 34447558382 scopus 로고    scopus 로고
    • Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein
    • Lin A.M., Fang S.F., Chao P.L., and Yang C.H. Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J. Pineal Res. 43 (2007) 163-171
    • (2007) J. Pineal Res. , vol.43 , pp. 163-171
    • Lin, A.M.1    Fang, S.F.2    Chao, P.L.3    Yang, C.H.4
  • 67
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu J., Solway K., Messing R.O., and Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18 (1998) 7768-7778
    • (1998) J. Neurosci. , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 68
    • 0242384072 scopus 로고    scopus 로고
    • 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates
    • Maharaj D.S., Walker R.B., Glass B.D., and Daya S. 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. J. Chem. Neuroanat. 26 (2003) 1103-1107
    • (2003) J. Chem. Neuroanat. , vol.26 , pp. 1103-1107
    • Maharaj, D.S.1    Walker, R.B.2    Glass, B.D.3    Daya, S.4
  • 71
    • 34247346067 scopus 로고    scopus 로고
    • Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice
    • Manda K., Anzai K., Kumari S., and Bhatia A.L. Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice. Acta Neurobiol. Exp. (Wars) 67 (2007) 63-70
    • (2007) Acta Neurobiol. Exp. (Wars) , vol.67 , pp. 63-70
    • Manda, K.1    Anzai, K.2    Kumari, S.3    Bhatia, A.L.4
  • 72
    • 33845973382 scopus 로고    scopus 로고
    • Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid
    • Manda K., Ueno M., Moritake T., and Anzai K. Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behav. Brain Res. 177 (2007) 7-14
    • (2007) Behav. Brain Res. , vol.177 , pp. 7-14
    • Manda, K.1    Ueno, M.2    Moritake, T.3    Anzai, K.4
  • 73
    • 34147201601 scopus 로고    scopus 로고
    • AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice
    • Manda K., Ueno M., and Anzai K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J. Pineal Res. 42 (2007) 386-393
    • (2007) J. Pineal Res. , vol.42 , pp. 386-393
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 74
    • 39149135821 scopus 로고    scopus 로고
    • Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation
    • Manda K., Ueno M., and Anzai K. Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation. J. Pineal Res. 44 (2008) 189-196
    • (2008) J. Pineal Res. , vol.44 , pp. 189-196
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 75
    • 38049055711 scopus 로고    scopus 로고
    • Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid
    • Manda K., Ueno M., and Anzai K. Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid. Behav. Brain Res. 187 (2008) 387-395
    • (2008) Behav. Brain Res. , vol.187 , pp. 387-395
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 76
    • 53749104127 scopus 로고    scopus 로고
    • Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK
    • Manda K., Ueno M., and Anzai K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK. J. Pineal Res. 45 (2008) 430-438
    • (2008) J. Pineal Res. , vol.45 , pp. 430-438
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 77
    • 57149139038 scopus 로고    scopus 로고
    • Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment
    • Manda K., Ueno M., and Anzai K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. J. Pineal Res. 46 (2009) 71-78
    • (2009) J. Pineal Res. , vol.46 , pp. 71-78
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 78
    • 0033583580 scopus 로고    scopus 로고
    • Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
    • Markakis E.A., and Gage F.H. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J. Comp. Neurol. 406 (1999) 449-460
    • (1999) J. Comp. Neurol. , vol.406 , pp. 449-460
    • Markakis, E.A.1    Gage, F.H.2
  • 79
    • 0020037373 scopus 로고
    • Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues
    • Marklund S.L., Westman N.G., Lundgren E., and Roos G. Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res. 42 (1982) 1955-1961
    • (1982) Cancer Res. , vol.42 , pp. 1955-1961
    • Marklund, S.L.1    Westman, N.G.2    Lundgren, E.3    Roos, G.4
  • 81
  • 82
    • 0027763443 scopus 로고
    • Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence
    • Menendez-Pelaez A., Poeggeler B., Reiter R.J., Barlow-Walden L., Pablos M.I., and Tan D.X. Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence. J. Cell Biochem. 53 (1993) 373-382
    • (1993) J. Cell Biochem. , vol.53 , pp. 373-382
    • Menendez-Pelaez, A.1    Poeggeler, B.2    Reiter, R.J.3    Barlow-Walden, L.4    Pablos, M.I.5    Tan, D.X.6
  • 83
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization
    • Menendez-Pelaez A., and Reiter R.J. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J. Pineal Res. 15 (1993) 59-69
    • (1993) J. Pineal Res. , vol.15 , pp. 59-69
    • Menendez-Pelaez, A.1    Reiter, R.J.2
  • 84
    • 13644250791 scopus 로고    scopus 로고
    • Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade
    • Millan M.J., Brocco M., Gobert A., and Dekeyne A. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology (Berl.) 177 (2005) 448-458
    • (2005) Psychopharmacology (Berl.) , vol.177 , pp. 448-458
    • Millan, M.J.1    Brocco, M.2    Gobert, A.3    Dekeyne, A.4
  • 85
    • 0027287613 scopus 로고
    • Vitamin E is a complete tumor promotor in mouse skin
    • Mitchel R.E.J., and McCann R. Vitamin E is a complete tumor promotor in mouse skin. Carcinogenesis 14 (1993) 659-662
    • (1993) Carcinogenesis , vol.14 , pp. 659-662
    • Mitchel, R.E.J.1    McCann, R.2
  • 87
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • Monje M.L., Mizumatsu S., Fike J.R., and Palmer T.D. Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8 (2002) 955-962
    • (2002) Nat. Med. , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 88
    • 34147213579 scopus 로고    scopus 로고
    • Melatonin influences the proliferative and differentiative activity of neural stem cells
    • Moriya T., Horie N., Mitome M., and Shinohara K. Melatonin influences the proliferative and differentiative activity of neural stem cells. J. Pineal Res. 42 (2007) 411-418
    • (2007) J. Pineal Res. , vol.42 , pp. 411-418
    • Moriya, T.1    Horie, N.2    Mitome, M.3    Shinohara, K.4
  • 92
  • 93
    • 0003059447 scopus 로고
    • Effects of administration of natural vitamin E on spontaneous hepatocarcinogenesis and N-dinitrosodiethylamine initiated tumors in mice
    • Nitta Y., Kamiya K., Tanimoto M., Kagimoto O., Niwa O., and Yokoro K. Effects of administration of natural vitamin E on spontaneous hepatocarcinogenesis and N-dinitrosodiethylamine initiated tumors in mice. J. Toxicol. Pathol. 4 (1991) 55-61
    • (1991) J. Toxicol. Pathol. , vol.4 , pp. 55-61
    • Nitta, Y.1    Kamiya, K.2    Tanimoto, M.3    Kagimoto, O.4    Niwa, O.5    Yokoro, K.6
  • 94
    • 0025828978 scopus 로고
    • Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats
    • Nitta Y., Kamiya K., Tanimoto M., Sadamoto S., Niwa O., and Yokoro K. Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats. Jpn. J. Cancer Res. 82 (1991) 511-517
    • (1991) Jpn. J. Cancer Res. , vol.82 , pp. 511-517
    • Nitta, Y.1    Kamiya, K.2    Tanimoto, M.3    Sadamoto, S.4    Niwa, O.5    Yokoro, K.6
  • 95
  • 100
    • 0038050606 scopus 로고    scopus 로고
    • Effect of agomelatine in the chronic mild stress model of depression in the rat
    • Papp M., Gruca P., Boyer P.A., and Mocaer E. Effect of agomelatine in the chronic mild stress model of depression in the rat. Neuropsychopharmacology 28 (2003) 694-703
    • (2003) Neuropsychopharmacology , vol.28 , pp. 694-703
    • Papp, M.1    Gruca, P.2    Boyer, P.A.3    Mocaer, E.4
  • 102
    • 0033968704 scopus 로고    scopus 로고
    • An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease
    • Pappolla M.A., Chyan Y.J., Poeggeler B., Frangione B., Wilson G., Ghiso J., and Reiter R.J. An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. J. Neural. Transm. 107 (2000) 203-231
    • (2000) J. Neural. Transm. , vol.107 , pp. 203-231
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3    Frangione, B.4    Wilson, G.5    Ghiso, J.6    Reiter, R.J.7
  • 103
    • 0033152433 scopus 로고    scopus 로고
    • Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat
    • Parent J.M., Tada E., Fike J.R., and Lowenstein D.H. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J. Neurosci. 19 (1999) 4508-4519
    • (1999) J. Neurosci. , vol.19 , pp. 4508-4519
    • Parent, J.M.1    Tada, E.2    Fike, J.R.3    Lowenstein, D.H.4
  • 104
    • 51649122293 scopus 로고    scopus 로고
    • Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species
    • Peyrot F., and Ducrocq C. Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J. Pineal Res. 45 (2008) 235-246
    • (2008) J. Pineal Res. , vol.45 , pp. 235-246
    • Peyrot, F.1    Ducrocq, C.2
  • 107
    • 0025915557 scopus 로고
    • Melatonin: the chemical expression of darkness
    • Reiter R.J. Melatonin: the chemical expression of darkness. Mol. Cell Endocrinol. 79 (1991) C153-C158
    • (1991) Mol. Cell Endocrinol. , vol.79
    • Reiter, R.J.1
  • 108
    • 0031752712 scopus 로고    scopus 로고
    • Cytoprotective properties of melatonin: presumed association with oxidative damage and aging
    • Reiter R.J. Cytoprotective properties of melatonin: presumed association with oxidative damage and aging. Nutrition 14 (1998) 691-696
    • (1998) Nutrition , vol.14 , pp. 691-696
    • Reiter, R.J.1
  • 109
    • 0031845040 scopus 로고    scopus 로고
    • Oxidative damage in the central nervous system: protection by melatonin
    • Reiter R.J. Oxidative damage in the central nervous system: protection by melatonin. Prog. Neurobiol. 56 (1998) 359-384
    • (1998) Prog. Neurobiol. , vol.56 , pp. 359-384
    • Reiter, R.J.1
  • 110
    • 0034930671 scopus 로고    scopus 로고
    • Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system
    • Reiter R.J., Acuna-Castroviejo D., Tan D.X., and Burkhardt S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann. N. Y. Acad. Sci. 939 (2001) 200-215
    • (2001) Ann. N. Y. Acad. Sci. , vol.939 , pp. 200-215
    • Reiter, R.J.1    Acuna-Castroviejo, D.2    Tan, D.X.3    Burkhardt, S.4
  • 112
    • 12744273107 scopus 로고    scopus 로고
    • When melatonin gets on your nerves: its beneficial actions in experimental models of stroke
    • Reiter R.J., Tan D.X., Leon J., Kilic U., and Kilic E. When melatonin gets on your nerves: its beneficial actions in experimental models of stroke. Exp. Biol. Med. 230 (2005) 104-117
    • (2005) Exp. Biol. Med. , vol.230 , pp. 104-117
    • Reiter, R.J.1    Tan, D.X.2    Leon, J.3    Kilic, U.4    Kilic, E.5
  • 113
    • 38149140283 scopus 로고    scopus 로고
    • Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage
    • Reiter R.J., Tan D.X., Manchester L.C., and Tamura H. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J. Physiol. Pharmacol. 58 Suppl. 6 (2007) 5-22
    • (2007) J. Physiol. Pharmacol. , vol.58 , Issue.SUPPL. 6 , pp. 5-22
    • Reiter, R.J.1    Tan, D.X.2    Manchester, L.C.3    Tamura, H.4
  • 118
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: current knowledge and future directions
    • Roman D.D., and Sperduto P.W. Neuropsychological effects of cranial radiation: current knowledge and future directions. Int. J. Radiat. Oncol. Biol. Phys. 31 (1995) 983-998
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 119
    • 34548348778 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in depression
    • Sahay A., and Hen R. Adult hippocampal neurogenesis in depression. Nat. Neurosci. 10 (2007) 1110-1115
    • (2007) Nat. Neurosci. , vol.10 , pp. 1110-1115
    • Sahay, A.1    Hen, R.2
  • 120
    • 4644356675 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle
    • Sakano K., Oikawa S., Hiraku Y., and Kawanishi S. Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle. Biochem. Pharmacol. 68 (2004) 1869-1878
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1869-1878
    • Sakano, K.1    Oikawa, S.2    Hiraku, Y.3    Kawanishi, S.4
  • 123
    • 57149130854 scopus 로고    scopus 로고
    • The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger
    • Schaefer M., and Hardeland R. The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger. J. Pineal Res. 46 (2009) 49-52
    • (2009) J. Pineal Res. , vol.46 , pp. 49-52
    • Schaefer, M.1    Hardeland, R.2
  • 124
  • 125
    • 0033791313 scopus 로고    scopus 로고
    • Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment
    • Seabra M.L., Bignotto M., Pinto Jr. L.R., and Tufik S. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J. Pineal Res. 29 (2000) 193-200
    • (2000) J. Pineal Res. , vol.29 , pp. 193-200
    • Seabra, M.L.1    Bignotto, M.2    Pinto Jr., L.R.3    Tufik, S.4
  • 128
    • 84985570313 scopus 로고
    • Biochemistry of oxidant stress
    • Sies H. Biochemistry of oxidant stress. Angew. Chem. Int. Ed. Engl. 25 (1986) 1058-1071
    • (1986) Angew. Chem. Int. Ed. Engl. , vol.25 , pp. 1058-1071
    • Sies, H.1
  • 129
    • 0033305177 scopus 로고    scopus 로고
    • High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus
    • Skinner D.C., and Malpaux B. High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus. Endocrinology 140 (1999) 4399-4405
    • (1999) Endocrinology , vol.140 , pp. 4399-4405
    • Skinner, D.C.1    Malpaux, B.2
  • 131
    • 0034995459 scopus 로고    scopus 로고
    • Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    • Snyder J.S., Kee N., and Wojtowicz J.M. Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J. Neurophysiol. 85 (2001) 2423-2431
    • (2001) J. Neurophysiol. , vol.85 , pp. 2423-2431
    • Snyder, J.S.1    Kee, N.2    Wojtowicz, J.M.3
  • 133
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • Tada E., Parent J.M., Lowenstein D.H., and Fike J.R. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99 (2000) 33-41
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3    Fike, J.R.4
  • 136
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan D.X., Manchester L.C., Terron M.P., Flores L.J., and Reiter R.J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?. J. Pineal Res. 42 (2007) 28-42
    • (2007) J. Pineal Res. , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 137
    • 0023101014 scopus 로고
    • Cabbage and vitamin E: their effect on colon tumor formation in mice
    • Temple N.J., and El-Khatib S.M. Cabbage and vitamin E: their effect on colon tumor formation in mice. Cancer Lett. 35 (1987) 71-77
    • (1987) Cancer Lett. , vol.35 , pp. 71-77
    • Temple, N.J.1    El-Khatib, S.M.2
  • 139
    • 0010607277 scopus 로고
    • The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
    • The alpha-tocopherol, beta carotene cancer prevention study group
    • The alpha-tocopherol, beta carotene cancer prevention study group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330 (1994) 1029-1035
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1029-1035
  • 141
    • 7644237780 scopus 로고    scopus 로고
    • Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease
    • Tunez I., Montilla P., Del Carmen Munoz M., Feijoo M., and Salcedo M. Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J. Pineal Res. 37 (2004) 252-256
    • (2004) J. Pineal Res. , vol.37 , pp. 252-256
    • Tunez, I.1    Montilla, P.2    Del Carmen Munoz, M.3    Feijoo, M.4    Salcedo, M.5
  • 144
    • 0032698584 scopus 로고    scopus 로고
    • Melatonin and protection from genetic damage in blood and bone marrow: whole-body irradiation studies in mice
    • Vijayalaxmi, Meltz M.L., Reiter R.J., and Herman T.S. Melatonin and protection from genetic damage in blood and bone marrow: whole-body irradiation studies in mice. J. Pineal Res. 27 (1999) 221-225
    • (1999) J. Pineal Res. , vol.27 , pp. 221-225
    • Vijayalaxmi1    Meltz, M.L.2    Reiter, R.J.3    Herman, T.S.4
  • 145
    • 0031773901 scopus 로고    scopus 로고
    • Enzymatic processing of radiation-induced free radical damage in DNA
    • Wallace S.S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res. 150 (1998) S60-79
    • (1998) Radiat. Res. , vol.150
    • Wallace, S.S.1
  • 147
    • 0030642008 scopus 로고    scopus 로고
    • Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications
    • Yeleswaram K., McLaughlin L.G., Knipe J.O., and Schabdach D. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. J. Pineal Res. 22 (1997) 45-51
    • (1997) J. Pineal Res. , vol.22 , pp. 45-51
    • Yeleswaram, K.1    McLaughlin, L.G.2    Knipe, J.O.3    Schabdach, D.4
  • 148
    • 0024398027 scopus 로고
    • Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes
    • Zaleska M.M., Nagy K., and Floyd R.A. Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes. Neurochem. Res. 14 (1989) 597-605
    • (1989) Neurochem. Res. , vol.14 , pp. 597-605
    • Zaleska, M.M.1    Nagy, K.2    Floyd, R.A.3


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