Memory impairment, oxidative damage and apoptosis induced by space radiation: Ameliorative potential of α-lipoic acid

Behavioural Brain Research

Volumn 187, Issue 2, 2008, Pages 387-395

  Manda, Kailash ^a   Ueno, Megumi ^a   Anzai, Kazunori ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Lipoic acid; Aging; Antioxidant; Cerebellum; Cognitive dysfunction; Oxidative stress; Space radiation; Spatial memory

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; DNA NUCLEOTIDYLEXOTRANSFERASE; IRON; NEUROPROTECTIVE AGENT; THIOCTIC ACID; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL DEATH; CEREBELLUM; CEREBELLUM INJURY; COGNITIVE DEFECT; COMET ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; COSMIC RADIATION; DNA DAMAGE; LIPID PEROXIDATION; MALE; MEMORY DISORDER; MOTOR ACTIVITY; MOUSE; MOUSE STRAIN; NICK END LABELING; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARTICLE RADIATION; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PURKINJE CELL; RADIATION INJURY; REFERENCE MEMORY; STATISTICAL SIGNIFICANCE; WHOLE BODY RADIATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CEREBELLUM; COSMIC RADIATION; DEOXYGUANOSINE; DNA DAMAGE; LIPID PEROXIDATION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RADIATION DOSAGE; RADIATION-PROTECTIVE AGENTS; RANDOM ALLOCATION; SPACE FLIGHT; THIOCTIC ACID;

EID: 38049055711     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.09.033     Document Type: Article

References (59)

1. Podda M., and Grundmann-Kollmann M. Low molecular weight antioxidants and their role in skin aging. Clin Exp Dermatol 26 (2001) 578-582
2. Riley P.A. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 65 (1994) 27-33
3. Sardesai V.M. Role of antioxidants in health maintenance. Nutr Clin Pract 10 (1995) 19-25
4. Guan J., Stewart J., Ware J.H., Zhou Z., Donahue J.J., and Kennedy A.R. Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA mice. Radiat Res 165 (2006) 373-378
5. Hollander J., Gore M., Fiebig R., Mazzeo R., Ohishi S., Ohno H., et al. Spaceflight downregulates antioxidant defense systems in rat liver. Free Radic Biol Med 24 (1998) 385-390
6. Ames B.N., Shigenaga M.K., and Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90 (1993) 7915-7922
7. Harman D. Role of free radicals in aging and disease. Ann NY Acad Sci 673 (1992) 126-141
8. Hauss-Wegrzyniak B., Vannucchi M.G., and Wenk G.L. Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats. Brain Res 859 (2000) 157-166
9. Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci 16 (1993) 439-444
10. Shukitt-Hale B., Carey A.N., Jenkins D., Rabin B.M., and Joseph J.A. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 28 (2007) 1187-1194
11. Higuchi Y., Nelson G.A., Vazquez M., Laskowitz D.T., Slater J.M., and Pearlstein R.D. Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. J Radiat Res 43 (2002) S219-S224
12. Sun J., Chen Y., Li M., and Ge Z. Role of antixodant enzymes on ionizing radiation resistance. Free Radic Biol Med 24 (1998) 586-593
13. 56Fe-particle radiation. Rad Res 158 (2002) 725-734
14. Gonenc S., Uysal N., Acikgoz O., Kayatekin B.M., Sonmez A., Kiray M., et al. Effects of melatonin on oxidative stress and spatial memory impairment induced by acute ethanol treatment in rats. Physiol Res 54 (2005) 341-348
15. Ozdemir D., Uysal N., Gonenc S., Acikgoz O., Sonmez A., Topcu A., et al. Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats. Physiol Res 54 (2005) 631-637
16. Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's diseases model rats. J Neurochem 81 (2002) 1084-1091
17. Hashimoto M., Tanabe Y., Fujii Y., Kikuta T., Shibata H., and Shido O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid β-infused rats. J Nutr 135 (2005) 549-555
18. Patockova J., Krsiak M., Marhol P., and Tumova E. Cerebrolysin inhibits lipid peroxidation induced by insulin hypoglycemia in the brain and heart of mice. Physiol Res 52 (2003) 455-460
19. Poeggeler B., Reiter R.J., Tan D.X., Chen L.D., and Manchester L.C. Melatonin, hydroxyl radical mediated oxidative damage, and aging: a hypothesis. J Pineal Res 14 (1993) 151-168
20. Bilska A., and Wlodek L. Lipoic acid-the drug of the future?. Pharmacol Rep 57 (2005) 570-577
21. Suzuki Y.J., Tsuchiya M., and Packer L. Lipoate prevents glucose-induced protein modifications. Free Radic Res Commun 17 (1992) 211-217
22. Fiez J.A. Cerebellar contributions to cognition. Neuron 16 (1996) 13-15
23. Frings M., Boenisch R., Gerwig M., Diener H.C., and Timmann D. Learning of sensory sequences in cerebellar patients. Learn Mem 11 (2004) 347-355
24. Lalonde R., and Strazielle C. The effects of cerebellar damage on maze learning in animals. Cerebellum 2 (2003) 300-309
25. Manda K., Ueno M., Moritake T., and Anzai K. Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of α-lipoic acid. Behav Brain Res 177 (2007) 7-14
26. Ramakrishnan N., Wolfe W.W., and Catravas G.N. Radioprotection of hematopoietic tissues in mice by lipoic acid. Radiat Res 130 (1992) 360-365
27. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175 (1988) 184-191
28. Evans P., Lyras L., and Halliwell B. Measurement of protein carbonyls in human brain tissues. Methods Enzymol 300 (1999) 145-157
29. Sedlak J., and Lindsay R.H. Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25 (1968) 192-205
30. Benzie I.F., and Strain J.J. The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay. Anal Biochem 239 (1996) 70-76
31. Haksar A., Sharma A., Chawla R., Kumar R., Arora R., Singh S., et al. Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner. Pharmacol Biochem Behav 84 (2006) 179-188
32. Manda K., Anzai K., Kumari S., and Bhatia A.L. Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice. Acta Neurobiol Exp 67 (2007) 63-70
33. Forster M.J., Dubey A., Dawson K.M., Stutts W.A., Lal H., and Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci USA 93 (1996) 4765-4769
34. Erickson C.A., and Barnes C.A. The neurobiology of memory changes in normal aging. Exp Gerontol 38 (2003) 61-69
35. Muir J.L., Fischer W., and Bjorklund A. Decline in visual attention and spatial memory in aged rats. Neurobiol Aging 20 (1999) 605-615
36. Grady C.L., Springer M.V., Hongwanishkul D., McIntosh A.R., and Winocur G. Age-related changes in brain activity across the adult lifespan. J Cogn Neurosci 18 (2006) 227-241
37. D'Hooge R., and De Deyn P.P. Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36 (2001) 60-90
38. Llinas R., Lang E.J., and Welsh J.P. The cerebellum, LTD, and memory: alternative views. Learn Mem 3 (1997) 444-445
39. Thach W.T. On the specific role of the cerebellum in motor learning and cognition: clues from PET activation and lesion studies in man. Behav Brain Sci 19 (1996) 411-431
40. Leiner H.C., Leiner A.L., and Dow R.S. Does the cerebellum contribute to mental skills?. Behav Neurosci 100 (1986) 443-454
41. Schmahmann J.D. An emerging concept. The cerebellar contribution to higher function. Arch Neurol 48 (1991) 1178-1187
42. Farr S.A., Poon H.F., Dogrukol-Ak D., Drake J., Banks W.A., Eyerman E., et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem 84 (2003) 1173-1183
43. Liu J., Head E., Gharib A.M., Yuan W., Ingersoll R.T., Hagen T.M., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA 99 (2002) 2356-2361
44. Cui X., Zuo P., Zhang Q., Li X., Hu Y., Long J., et al. Chronic systemic d-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 83 (2006) 1584-1590
45. Sharma M., and Gupta Y.K. Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats. Eur Neuropsychopharmacol 13 (2003) 241-247
46. Navarro A., Sanchez Del Pino M.J., Gomez C., Peralta J.L., and Boveris A. Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice. Am J Physiol Regul Integr Comp Physiol 282 (2002) R985-R992
47. Manda K., Ueno M., Moritake T., and Anzai K. α-Lipoic acid attenuates X-irradiation-induced oxidative stress in mice. Cell Biol Toxicol 23 (2007) 129-137
48. Arivazhagan P., Shila S., Kumaran S., and Panneerselvam C. Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats. Exp Gerontol 37 (2002) 803-811
49. Dincer Y., Telci A., Kayali R., Yilmaz I.A., Cakatay U., and Akcay T. Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats. Clin Exp Pharmacol Physiol 29 (2002) 281-284
50. Shila S., Kokilavani V., Subathra M., and Panneerselvam C. Brain regional responses in antioxidant system to alpha-lipoic acid in arsenic intoxicated rat. Toxicology 210 (2005) 25-36
51. Navarro A., and Boveris A. The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 292 (2007) C670-C686
52. Floyd R.A., and Carney J.M. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 32 (1992) S22-S27
53. Zaleska M.M., and Floyd R.A. Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron. Neurochem Res 10 (1985) 397-410
54. Marklund S.L., Westman N.G., Lundgren E., and Roos G. Copper and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42 (1982) 1955-1961
55. Weiss J.F., and Landauer M.R. Radioprotection by antioxidants. Ann NY Acad Sci 899 (2000) 44-60
56. Moran L.K., Gutteridge J.M.C., and Quinlan G.J. Thiols in cellular redox signaling and control. Curr Med Chem 8 (2001) 763-772
57. Sedlack J., and L'Hanus J. Changes of glutathione, protein bound SH-groups concentrations in rat adrenals under acute and repeated stress. Endocrinol Exp 16 (1982) 103-109
58. Dickinson D.A., and Forman H.J. Cellular glutathione and thiols metabolism. Biochem Pharmacol 64 (2002) 1019-1026
59. Diao M.F., Liu H.Y., Zhang Y.M., and Gao W.Y. Changes in antioxidant capacity of the guinea pig exposed to noise and the protective effect of α-lipoic acid against acoustic trauma. Acta Physiol Sinica 55 (2003) 672-676