The biological activity of G-quadruplex DNA binding papaverine-derived ligand in breast cancer cells

Investigational New Drugs

Volumn 27, Issue 4, 2009, Pages 289-296

  Rubis, Blazej ^a   Kaczmarek, Mariusz ^a   Szymanowska, Natalia ^a   Galezowska, Elzbieta ^b   Czyrski, Andrzej ^a   Juskowiak, Bernard ^b   Hermann, Tadeusz ^a   Rybczynska, Maria ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

Breast cancer; Cell cycle arrest; DNA binding; G quadruplex DNA; Papaverine derivative; Telomerase inhibitor

Indexed keywords

6A,12A DIAZADIBENZO[A,G]FLUORENYLIUM DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLINE; GUANINE QUADRUPLEX; LIGAND; PAPAVERINE DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG ACCUMULATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G-QUADRUPLEXES; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MICROSCOPY, FLUORESCENCE; OXIDATION-REDUCTION; PAPAVERINE; PROLIFERATING CELL NUCLEAR ANTIGEN; TELOMERASE;

EID: 67651160933     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9173-9     Document Type: Article

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