Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 8113-8122

  Takeuchi, Toshifumi ^a   Takahashi, Noriyuki ^a   Ishi, Kazutomo ^a   Kusayanagi, Tomoe ^a   Kuramochi, Kouji ^a   Sugawara, Fumio ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

, Unsaturated lactone; Covalent bond; Fostriecin; Protein phosphatase 2A catalytic subunit

Indexed keywords

BIOTIN; FOSTRIECIN; PHOSPHOPROTEIN PHOSPHATASE 2A;

ADDITION REACTION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; COVALENT BOND; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MAMMAL CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN;

ALKENES; AMINO ACID SEQUENCE; ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL SURVIVAL; CYSTEINE; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN PHOSPHATASE 2; PYRONES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

MAMMALIA;

EID: 71849099556     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.050     Document Type: Article

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