Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin-3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

Blood

Volumn 97, Issue 5, 2001, Pages 1289-1297

  Chiang, Chi Wu ^b   Harris, Gregory ^b   Ellig, Cindy ^b   Masters, Shane C ^b   Subramanian, Romesh ^b   Shenolikar, Shirish ^b   Wadzinski, Brian E ^b   Yang, Elizabeth ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BAD; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; LYMPHOID CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT;

EID: 0035283087     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.5.1289     Document Type: Article

References (61)

1. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
2. Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice
3. Molecular thanatopsis: A discourse on the BCL2 family and cell death
4. The Bcl-2 protein family: Arbiters of cell survival
5. Mitochondria and apoptosis
6. BCL-2 family members and the mitochondria in apoptosis
7. L
8. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
9. A member of forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction
10. Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors
11. Interleukin-3 and bryostatin-1 mediate hyper-phosphorylation of BCL2 alpha in association with suppression of apoptosis
12. Bcl-2 phosphorylation required for anti-apoptosis function
13. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
14. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
15. L and Bcl-2, displaces Bax and promotes cell death
16. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
17. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
18. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155
19. L interaction and cell survival
20. 14-3-3 Proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
21. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site. Ser 155
22. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
23. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
24. Protein phosphatase 1α is a ras-activated Bad phosphatase that regulates intedeukin-2 deprivation-induced apoptosis
25. Importance of the β12-β13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors
26. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
27. Production of high-titer helper-free retroviruses by transient transfection
28. 14-3-3ζ binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove
29. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display
30. Use of immunocomplexed substrate for detecting PP1 activity
31. Histone H1 phosphorylated by protein kinase C is a selective substrate for the assay of protein phosphatase 2A in the presence of phosphatase 1
32. Comparison of the substrate specificities of protein phosphatases involved in the regulation of glycogen metabolism in rabbit skeletal muscle
33. Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein: PP2A regulates the activities of G(1) cyclin-dependent kinases
34. Protein serine/threonine phosphatases and cell transformation
35. Protein serine/threonine phosphatases: New avenues for cell regulation
36. Novel protein serine/threonine phosphatases: Variety is the spice of life
37. Regulation of protein kinase cascades by protein phosphatase 2A
38. Novel antitumor agents CI-920, PD 113,270 and PD 113,271, II: Isolation and characterization
39. In vitro activity of the novel antitumor antibiotic fostriecin (CI-920) in a human tumor cloning assay
40. Anticancer activity of the structurally novel antibiotic CI-920 and its analogues
41. Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A
42. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A
43. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: Method of analysis of interactions of tight-binding ligands with target protein
44. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
45. Specific binding of okadaic acid, a new tumor promoter in mouse skin
46. 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor
47. Physiologic importance of protein phosphatase inhibitors
48. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP
49. Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis
50. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
51. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin
52. Comparison of heterotrimeric protein phosphatase 2A containing different B subunits
53. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
54. Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits
55. 14-3-3 proteins: Structure, function, and regulation
56. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases
57. Protein kinase C activation by acidic proteins including 14-3-3
58. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
59. Interleukin-3-dependent survival by the Akt protein kinase
60. Caspase-dependent cleavage of signaling proteins during apoptosis: A turn-off mechanism for anti-apoptotic signals
61. Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo