메뉴 건너뛰기




Volumn 8, Issue 5, 2003, Pages 280-283

Double-drug development against antioxidant enzymes from Plasmodium falciparum

Author keywords

[No Author keywords available]

Indexed keywords

10 (3',5' DICHLOROPHENYL) 3 METHYLISOALLOXAZINE; 4 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; ANTIOXIDANT; CHLOROQUINE; DITHIOL DERIVATIVE; ESTER DERIVATIVE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; GLUTATHIONE REDUCTASE INHIBITOR; HEME; HEXANOIC ACID DERIVATIVE; MENADIONE; METHYLENE BLUE; NAPHTHAZARIN; NEW DRUG; OXIDOREDUCTASE INHIBITOR; PRODRUG; REACTIVE OXYGEN METABOLITE; TETRAZOLE DERIVATIVE; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0346398299     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100003225002916     Document Type: Article
Times cited : (26)

References (20)
  • 1
    • 0028828562 scopus 로고
    • Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells
    • Atamna H, Ginsburg H. Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells. J Biol Chem 1995; 270: 24876-24883.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24876-24883
    • Atamna, H.1    Ginsburg, H.2
  • 2
    • 0031792787 scopus 로고    scopus 로고
    • Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
    • Ginsburg H, Famin O, Zhang J, Krugliak M. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action. Biochem Pharmacol 1998; 56: 1305-1313.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1305-1313
    • Ginsburg, H.1    Famin, O.2    Zhang, J.3    Krugliak, M.4
  • 3
    • 33748233963 scopus 로고
    • Disulfide reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria
    • Schirmer RH, Müller JG, Krauth-Siegel RL. Disulfide reductase inhibitors as chemotherapeutic agents: the design of drugs for trypanosomiasis and malaria. Angew Chem Int Edn 1995; 34: 141-154.
    • (1995) Angew Chem. Int. Edn. , vol.34 , pp. 141-154
    • Schirmer, R.H.1    Müller, J.G.2    Krauth-Siegel, R.L.3
  • 4
    • 0035935690 scopus 로고    scopus 로고
    • A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline
    • Davioud-Charvet E, Delarue S, Biot C et al. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J Med Chem 2001; 44: 4268-4276.
    • (2001) J. Med. Chem. , vol.44 , pp. 4268-4276
    • Davioud-Charvet, E.1    Delarue, S.2    Biot, C.3
  • 5
    • 0037115759 scopus 로고    scopus 로고
    • Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum
    • Meierjohann S, Walter RD, Muller S. Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. Biochem J 2002; 368: 761-768.
    • (2002) Biochem. J. , vol.368 , pp. 761-768
    • Meierjohann, S.1    Walter, R.D.2    Muller, S.3
  • 6
    • 0034704081 scopus 로고    scopus 로고
    • The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited
    • Kanzok SM, Schirmer RH, Turbachova I, Iozef R, Becker K. The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited. J Biol Chem 2000; 275: 40180-40186.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40180-40186
    • Kanzok, S.M.1    Schirmer, R.H.2    Turbachova, I.3    Iozef, R.4    Becker, K.5
  • 7
    • 0043096998 scopus 로고    scopus 로고
    • Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue
    • Farber PM, Arscott LD, Williams Jr CH, Becker K, Schirmer RH. Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett 1998; 422: 311-314.
    • (1998) FEBS Lett. , vol.422 , pp. 311-314
    • Farber, P.M.1    Arscott, L.D.2    Williams Jr., C.H.3    Becker, K.4    Schirmer, R.H.5
  • 8
    • 0029940171 scopus 로고    scopus 로고
    • Inhibition of human glutathione reductase by 10-arylisoalloxazines: Crystalline, kinetic, and electrochemical studies
    • Schonleben-Janas A, Kirsch P, Mittl PR, Schirmer RH, Krauth-Siegel RL. Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. J Med Chem 1996; 39: 1549-1554.
    • (1996) J. Med. Chem. , vol.39 , pp. 1549-1554
    • Schonleben-Janas, A.1    Kirsch, P.2    Mittl, P.R.3    Schirmer, R.H.4    Krauth-Siegel, R.L.5
  • 9
    • 0024959343 scopus 로고
    • A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution
    • Karplus PA, Pai EF, Schulz GE. A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution. Eur J Biochem 1989; 178: 693-703.
    • (1989) Eur. J. Biochem. , vol.178 , pp. 693-703
    • Karplus, P.A.1    Pai, E.F.2    Schulz, G.E.3
  • 10
    • 0035865881 scopus 로고    scopus 로고
    • 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity
    • Salmon-Chemin L, Buisine E, Yardley V et al. 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. J Med Chem 2001; 44: 548-565.
    • (2001) J. Med. Chem. , vol.44 , pp. 548-565
    • Salmon-Chemin, L.1    Buisine, E.2    Yardley, V.3
  • 11
    • 0035899179 scopus 로고    scopus 로고
    • Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines
    • Delarue S, Girault S, Maes L et al. Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. J Med Chem 2001; 44: 2827-2833.
    • (2001) J. Med. Chem. , vol.44 , pp. 2827-2833
    • Delarue, S.1    Girault, S.2    Maes, L.3
  • 12
    • 0036498425 scopus 로고    scopus 로고
    • A double-headed pro-drug that overcomes chloroquine resistance
    • Ginsburg H. A double-headed pro-drug that overcomes chloroquine resistance. Trends Parasitol 2002; 18: 103.
    • (2002) Trends Parasitol. , vol.18 , pp. 103
    • Ginsburg, H.1
  • 13
    • 0037135586 scopus 로고    scopus 로고
    • Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages
    • Krnajski Z, Gilberger TW, Walter RD, Cowman AF, Muller S. Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J Biol Chem 2002; 277: 25970-25975.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25970-25975
    • Krnajski, Z.1    Gilberger, T.W.2    Walter, R.D.3    Cowman, A.F.4    Muller, S.5
  • 14
    • 0033215010 scopus 로고    scopus 로고
    • Enzymes of parasite thiol metabolism as drug targets
    • Krauth-Siegel RL, Coombs GH. Enzymes of parasite thiol metabolism as drug targets. Parasitol Today 1999; 15: 404-409.
    • (1999) Parasitol. Today , vol.15 , pp. 404-409
    • Krauth-Siegel, R.L.1    Coombs, G.H.2
  • 15
    • 0035838848 scopus 로고    scopus 로고
    • Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives
    • Dessolin J, Biot C, Davioud-Charvet E. Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives. J Org Chem 2001; 66: 5616-5619.
    • (2001) J. Org. Chem. , vol.66 , pp. 5616-5619
    • Dessolin, J.1    Biot, C.2    Davioud-Charvet, E.3
  • 16
    • 0347908853 scopus 로고    scopus 로고
    • Disulfide reductases - Current developments
    • Chapman SK, Perham RN, Scrutton NS. (eds) Berlin: Agency for Scientific Publications
    • Irmler A, Bechthold A, Davioud-Charvet E et al. Disulfide reductases - current developments. In: Chapman SK, Perham RN, Scrutton NS. (eds) Flavins and Flavoproteins 2002. Berlin: Agency for Scientific Publications, 2002; 803-815.
    • (2002) Flavins and Flavoproteins 2002 , pp. 803-815
    • Irmler, A.1    Bechthold, A.2    Davioud-Charvet, E.3
  • 17
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997; 46: 3-26.
    • (1997) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 19
    • 0029987752 scopus 로고    scopus 로고
    • Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo
    • Atamna H, Krugliak M, Shalmiev G, Deharo E, Pescarmona G, Ginsburg H. Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo. Biochem Pharmacol 1996; 51: 693-700.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 693-700
    • Atamna, H.1    Krugliak, M.2    Shalmiev, G.3    Deharo, E.4    Pescarmona, G.5    Ginsburg, H.6
  • 20
    • 0347278578 scopus 로고    scopus 로고
    • Carboxylic acid surrogates and prodrugs of Plasmodium falciparum glutathione reductase inhibitors: Synthesis of 5-substituted tetrazoles, bioisosterism and mechanistic studies. Unpublished results
    • Biot C, Bauer H, Schirmer H, Davioud-Charvet E. Carboxylic acid surrogates and prodrugs of Plasmodium falciparum glutathione reductase inhibitors: Synthesis of 5-substituted tetrazoles, bioisosterism and mechanistic studies. Unpublished results
    • Biot, C.1    Bauer, H.2    Schirmer, H.3    Davioud-Charvet, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.