'Double-drugs' - A new class of prodrug form of an HIV protease inhibitor conjugated with a reverse transcriptase inhibitor by a spontaneously cleavable linker

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 11, 2000, Pages 1227-1231

  Matsumoto, Hikaru ^a   Hamawaki, Tomonori ^a   Ota, Hisashi ^a   Kimura, Tooru ^a   Goto, Toshiyuki ^b   Sano, Kouichi ^b   Hayashi, Yoshio ^a   Kiso, Yoshiaki ^a  

^a Kyoto University   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE DERIVATIVE; KINOSTATIN 1039; KYNOSTATIN 1038; KYNOSTATIN 1046; KYNOSTATIN 1047; KYNOSTATIN 727; PRODRUG; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG CONJUGATION; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; PRODRUGS; REVERSE TRANSCRIPTASE INHIBITORS; THIAZOLES; ZIDOVUDINE;

RNA VIRUSES;

EID: 0034608706     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00202-X     Document Type: Article

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