Polyunsaturated fatty acids and cardiovascular disease

Current Pharmaceutical Design

Volumn 15, Issue 36, 2009, Pages 4094-4102

  Calzolari, Ivan ^a   Fumagalli, Stefano ^a   Marchionni, Niccolò ^a   Di Bari, Mauro ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cardiovascular disease; Coronary heart disease; Heart failure; Polyunsaturated fatty acids; Sudden death

Indexed keywords

ACETYLSALICYLIC ACID; ALLYL ISOTHIOCYANATE; ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID;

ADJUVANT THERAPY; BIOCHEMISTRY; BIOLOGICAL ACTIVITY; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIET SUPPLEMENTATION; DIET THERAPY; DIETARY INTAKE; DRUG MEGADOSE; DRUG WITHDRAWAL; EATING HABIT; ELDERLY CARE; FATTY ACID ANALYSIS; FISH MEAT; GASTROINTESTINAL SYMPTOM; HALITOSIS; HEART FAILURE; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; STABLE ANGINA PECTORIS;

ANIMALS; CARDIOVASCULAR DISEASES; DIET; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FISHES; HUMANS;

EID: 71849085163     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161209789909755     Document Type: Review

References (84)

1. Kromann N, Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand 1980; 208: 401-406
2. Dyerberg J, Jorgensen KA. Marine oils and thrombogenesis. Prog Lipid Res 1982; 21: 255-269
3. Bang HO, Dyerberg J, Hjoorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand 1976; 200: 69-73.
4. Simopoulos AP. Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? Free Radic Biol Med 1994; 17: 367-372
5. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N, Jr. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 2001; 42: 1257-1265
6. Vermunt SH, Mensink RP, Simonis MM, Hornstra G. Effects of dietary alpha-linolenic acid on the conversion and oxidation of 13C-alpha-linolenic acid. Lipids 2000; 35: 137-142 (Pubitemid 30183643)
7. Sanderson P, Finnegan YE, Williams CM, Calder PC, Burdge GC, Wootton SA, et al. UK Food Standards Agency alpha-linolenic acid workshop report. Br J Nutr 2002; 88: 573-579 (Pubitemid 35363362)
8. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins Leukot Essent Fatty Acids 2003; 69: 283-290
9. Cartwright IJ, Pockley AG, Galloway JH, Greaves M, Preston FE. The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. Atherosclerosis 1985; 55: 267-281
10. Weber PC, Leaf A. Cardiovascular effects of omega 3 fatty acids. Atherosclerosis risk factor modification by omega 3 fatty acids. World Rev Nutr Diet 1991; 66:218-232
11. Radack K, Deck C, Huster G. Dietary supplementation with low-dose fish oils lowers fibrinogen levels: a randomized, double-blind controlled study. Ann Intern Med 1989; 111: 757-758 (Pubitemid 19266116)
12. DeCaterina R, Giannessi D, Mazzone A, Bernini W, Lazzerini G, Maffei S, et al. Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery. Circulation 1990; 82: 428-438 (Pubitemid 20257821)
13. Fox PL, DiCorleto PE. Fish oils inhibit endothelial cell production of platelet-derived growth factor-like protein. Science 1988; 241: 453-456
14. Shimokawa H, Vanhoutte PM. Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 1988; 78: 1421-1430 (Pubitemid 19004244)
15. Chen LY, Lawson DL, Mehta JL. Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. Thromb Res 1994; 76: 317-322
16. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995; 57: 827-872
17. Kremer JM, Jubiz W, Michalek A, Rynes RI, Bartholomew LE, Bigaouette J et al. Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled, crossover study. Ann Intern Med 1987; 106: 497-503.
18. Lee TH, Hoover RL, Williams JD, Sperling RI, Ravalese J, III, Spur BW et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985; 312: 1217-1224
19. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989; 320: 265-271 (Pubitemid 19045549)
20. Kremer JM, Robinson DR: Studies of dietary supplementation with omega 3 fatty acids in patients with rheumatoid arthritis. World Rev Nutr Diet 1991; 66: 367-382
21. Calder PC: Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 2006; 75: 197-202.
22. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 1993; 171: 223-229 (Pubitemid 23345967)
23. O'Brien KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest 1993; 92: 945-951 (Pubitemid 23262418)
24. Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson-Tidey RR: Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 1992; 140: 665-673
25. Richardson M, Hadcock SJ, DeReske M, Cybulsky MI: Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler Thromb 1994; 14: 760-769
26. Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 2003; 361: 477-485 (Pubitemid 36173713)
27. Billman GE, Kang JX, Leaf A: Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation 1999; 99: 2452-2457
28. McLennan PL, Bridle TM, Abeywardena MY, Charnock JS: Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am Heart J 1992; 123: 1555-1561
29. Leaf A, Kang JX, Xiao YF, Billman GE: Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 2003; 107: 2646-2652 (Pubitemid 36667234)
30. Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, et al. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 2005; 111: 157-164 (Pubitemid 40139726)
31. Christensen JH, Korup E, Aaroe J, Toft E, Moller J, Rasmussen K, et al. Fish consumption, n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction. Am J Cardiol 1997; 79: 1670-1673 (Pubitemid 27339480)
32. Christensen JH, Skou HA, Fog L, Hansen V, Vesterlund T, Dyerberg J, et al. Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation 2001; 103: 651-657 (Pubitemid 32144192)
33. Katan MB, Zock PL, Mensink RP: Dietary oils, serum lipoproteins, and coronary heart disease. Am J Clin Nutr 1995; 61: 1368S-73.
34. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815-1821 (Pubitemid 34303626)
35. Daviglus ML, Stamler J, Orencia AJ, Dyer AR, Liu K, Greenland P, et al. Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046-1053 (Pubitemid 27163856)
36. Kromhout D, Bosschieter EB, de Lezenne CC: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985; 312: 1205-1209 (Pubitemid 15009153)
37. Dolecek TA: Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proc Soc Exp Biol Med 1992; 200: 177-182
38. Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, et al. Fish consumption and risk of sudden cardiac death. JAMA 1998; 279: 23-28 (Pubitemid 28070546)
39. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995; 274: 1363-1367
40. Yuan JM, Ross RK, Gao YT, Yu MC. Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China. Am J Epidemiol 2001; 154: 809-816
41. Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 2002; 346: 1113-1118 (Pubitemid 34984601)
42. Lemaitre RN, King IB, Mozaffarian D, Kuller LH, Tracy RP, Siscovick DS. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr 2003; 77: 319-325 (Pubitemid 36133372)
43. Bulliyya G: Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish-consuming and non-fish-consuming populations. Asia Pac J Clin Nutr 2002; 11: 104-111
44. Dewailly E, Blanchet C, Gingras S, Lemieux S, Holub BJ. Fish consumption and blood lipids in three ethnic groups of Quebec (Canada). Lipids 2003; 38: 359-365 (Pubitemid 36724292)
45. Hu FB, Cho E, Rexrode KM, Albert CM, Manson JE: Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women. Circulation 2003; 107: 1852-1857 (Pubitemid 36444124)
46. Hartweg J, Perera R, Montori V, Dinneen S, Neil HA, Farmer A. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008; CD003205.
47. Erkkila AT, Lichtenstein AH, Mozaffarian D, Herrington DM. Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 2004; 80: 626-632 (Pubitemid 41115527)
48. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815-1821 (Pubitemid 34303626)
49. Tavani A, Pelucchi C, Negri E, Bertuzzi M, La Vecchia C. n-3 Polyunsaturated fatty acids, fish, and nonfatal acute myocardial infarction. Circulation 2001; 104: 2269-2272
50. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, et al. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2006; 113: 195-202.
51. Miettinen TA, Naukkarinen V, Huttunen JK, Mattila S, Kumlin T. Fatty-acid composition of serum lipids predicts myocardial infarction. Br Med J (Clin Res Ed) 1982; 285: 993-996
52. He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, et al. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke 2004; 35: 1538-1542
53. Sauvaget C, Nagano J, Allen N, Grant EJ, Beral V. Intake of animal products and stroke mortality in the Hiroshima/Nagasaki Life Span Study. Int J Epidemiol 2003; 32: 536-543 (Pubitemid 37039005)
54. He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 2004; 109: 2705-2711
55. Ascherio A, Rimm EB, Stampfer MJ, Giovannucci EL, Willett WC. Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. N Engl J Med 1995; 332: 977-982
56. Hunter DJ, Kazda I, Chockalingam A, Fodor JG. Fish consumption and cardiovascular mortality in Canada: an inter-regional comparison. Am J Prev Med 1988; 4: 5-10.
57. Morris MC, Manson JE, Rosner B, Buring JE, Willett WC, Hennekens CH. Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. Am J Epidemiol 1995; 142: 166-175
58. Kromhout D, Feskens EJ, Bowles CH. The protective effect of a small amount of fish on coronary heart disease mortality in an elderly population. Int J Epidemiol 1995; 24: 340-345
59. Guallar E, Aro A, Jimenez FJ, Martin-Moreno JM, Salminen I, van't Veer P, et al. Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study. Arterioscler Thromb Vasc Biol 1999; 19: 1111-1118
60. Oomen CM, Feskens EJ, Rasanen L, Fidanza F, Nissinen AM, Menotti A, et al. Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am J Epidemiol 2000; 151: 999-1006.
61. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007; 369: 1090-1098
62. Saito Y, Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Ishikawa Y, et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: subanalysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis 2008; 200: 135-140
63. Mozaffarian D. JELIS, fish oil, and cardiac events. Lancet 2007; 369: 1062-1063
64. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2: 757-761
65. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999; 354: 447-455
66. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999; 99: 779-785
67. Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002; 105: 1897-1903
68. Macchia A, Levantesi G, Franzosi MG, Geraci E, Maggioni AP, Marfisi R, et al. Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsaturated fatty acids. Eur J Heart Fail 2005; 7: 904-909
69. Burr ML, Ashfield-Watt PA, Dunstan FD, Fehily AM, Breay P, Ashton T, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 2003; 57: 193-200. (Pubitemid 36240469)
70. Gissi-Hf I. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008; 372(9645): 1223-1230
71. Singh RB, Niaz MA, Sharma JP, Kumar R, Rastogi V, Moshiri M. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival - 4. Cardiovasc Drugs Ther 1997; 11: 485-491 (Pubitemid 27367714)
72. Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002; 112: 298-304. (Pubitemid 34219443)
73. Hooper L, Thompson RL, Harrison RA, Summerbell CD, Ness AR, Moore HJ, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006; 332: 752-760 (Pubitemid 44365649)
74. Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S. Fish, meat, and risk of dementia: cohort study. BMJ 2002; 325: 932-933 (Pubitemid 35265208)
75. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM, et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 1997; 42: 776-782
76. Kalmijn S. Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies. J Nutr Health Aging 2000; 4: 202-207 (Pubitemid 32044692)
77. Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gomez-Aracena J et al. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 2002; 347: 1747-1754
78. Shimizu H, Ohtani K, Tanaka Y, Sato N, Mori M, Shimomura Y: Long-term effect of eicosapentaenoic acid ethyl (EPA-E) on albuminuria of non-insulin dependent diabetic patients. Diabetes Res Clin Pract 1995; 28: 35-40.
79. Kris-Etherton PM, Harris WS, Appel LJ: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002; 106: 2747-2757 (Pubitemid 35364932)
80. Mikhailidis DP, Winder AF: Use of statins. Results of different studies differed greatly. BMJ 1997; 315: 1617.
81. Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA, et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart 2001; 85: 544-548 (Pubitemid 32973499)
82. Abozguia K, Shivu GN, Ahmed I, Phan TT, Frenneaux MP. The heart metabolism: pathophysiological aspects in ischaemia and heart failure. Curr Pharm Des 2009; 15(8): 827-835
83. Di Napoli P, Barsotti A. Prognostic relevance of metabolic approach in patients with heart failure. Curr Pharm Des 2009; 15(8): 883-892
84. Marazzi G, Rosanio S, Caminiti G, Dioguardi FS, Mercuro G. The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure. Curr Pharm Des 2008; 14(25): 2592-2604