메뉴 건너뛰기




Volumn 14, Issue 23-24, 2009, Pages 1136-1142

Anticancer drug discovery in the future: an evolutionary perspective

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOCETAXEL; EPOSIN; ETOPHOS; ETOPOSIDE; IRINOTECAN; NATURAL PRODUCT; PACLITAXEL; PODOPHYLLOTOXIN; TOPOTECAN; TRABECTEDIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

EID: 71749104056     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2009.09.006     Document Type: Review
Times cited : (90)

References (61)
  • 1
    • 11144242211 scopus 로고    scopus 로고
    • Timeline-chemotherapy and the war on cancer
    • Chabner B.A., and Roberts T.G. Timeline-chemotherapy and the war on cancer. Nat. Rev. Cancer 5 (2005) 65-72
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 65-72
    • Chabner, B.A.1    Roberts, T.G.2
  • 2
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers C. Targeted cancer therapy. Nature 432 (2004) 294-297
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 3
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: when the whole is greater than the sum of the parts
    • Zimmermann G.R., et al. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today 12 (2007) 34-42
    • (2007) Drug Discov. Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1
  • 4
    • 34447091994 scopus 로고    scopus 로고
    • Preclinical and clinical safety of monoclonal antibodies
    • Tabrizi M.A., and Roskos L.K. Preclinical and clinical safety of monoclonal antibodies. Drug Discov. Today 12 (2007) 540-547
    • (2007) Drug Discov. Today , vol.12 , pp. 540-547
    • Tabrizi, M.A.1    Roskos, L.K.2
  • 5
    • 58149123345 scopus 로고    scopus 로고
    • Is there a case for selectively promiscuous anticancer drugs?
    • Fernandez A., et al. Is there a case for selectively promiscuous anticancer drugs?. Drug Discov. Today 14 (2009) 1-5
    • (2009) Drug Discov. Today , vol.14 , pp. 1-5
    • Fernandez, A.1
  • 6
    • 33746151619 scopus 로고    scopus 로고
    • Methodological aspects of current problems in target-based anticancer drug development
    • Yamanaka T., et al. Methodological aspects of current problems in target-based anticancer drug development. Int. J. Clin. Oncol. 11 (2006) 167-175
    • (2006) Int. J. Clin. Oncol. , vol.11 , pp. 167-175
    • Yamanaka, T.1
  • 7
    • 0038461995 scopus 로고    scopus 로고
    • Drugs from the deep: marine natural products as drug candidates
    • Haefner B. Drugs from the deep: marine natural products as drug candidates. Drug Discov. Today 8 (2003) 536-544
    • (2003) Drug Discov. Today , vol.8 , pp. 536-544
    • Haefner, B.1
  • 8
    • 58149189779 scopus 로고    scopus 로고
    • Drug development from marine natural products
    • Molinski T.F., et al. Drug development from marine natural products. Nat. Rev. Drug Discov. 8 (2009) 69-85
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 69-85
    • Molinski, T.F.1
  • 9
    • 58149190072 scopus 로고    scopus 로고
    • Metabolic engineering of microorganisms: general strategies and drug production
    • Lee S.Y., et al. Metabolic engineering of microorganisms: general strategies and drug production. Drug Discov. Today 14 (2009) 78-88
    • (2009) Drug Discov. Today , vol.14 , pp. 78-88
    • Lee, S.Y.1
  • 10
    • 0036488643 scopus 로고    scopus 로고
    • Natural products in cancer chemotherapy: past, present and future
    • Mann J. Natural products in cancer chemotherapy: past, present and future. Nat. Rev. Cancer 2 (2002) 143-148
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 143-148
    • Mann, J.1
  • 11
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus breoifolia
    • Wani M.C., et al. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus breoifolia. J. Am. Chem. Soc. 93 (1971) 2325-2327
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 2325-2327
    • Wani, M.C.1
  • 12
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff P.B., et al. Promotion of microtubule assembly in vitro by taxol. Nature 277 (1979) 665-667
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1
  • 13
    • 33947717002 scopus 로고    scopus 로고
    • Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents
    • Altmann K.H., and Gertsch J. Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents. Nat. Prod. Rep. 24 (2007) 327-357
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 327-357
    • Altmann, K.H.1    Gertsch, J.2
  • 14
    • 0000211211 scopus 로고
    • Mesozoic conifers
    • Miller C.N. Mesozoic conifers. Bot. Rev. 43 (1977) 217-280
    • (1977) Bot. Rev. , vol.43 , pp. 217-280
    • Miller, C.N.1
  • 15
    • 0034115566 scopus 로고    scopus 로고
    • Phylogeny of taxaceae and cephalotaxaceae tenera inferred from chloroplast matK gene and nuclear rDNA ITS region
    • Cheng Y.C., et al. Phylogeny of taxaceae and cephalotaxaceae tenera inferred from chloroplast matK gene and nuclear rDNA ITS region. Mol. Phylogenet. Evol. 14 (2000) 353-365
    • (2000) Mol. Phylogenet. Evol. , vol.14 , pp. 353-365
    • Cheng, Y.C.1
  • 16
    • 7144248725 scopus 로고
    • Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
    • Wall M.E., et al. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 88 (1966) 3888-3890
    • (1966) J. Am. Chem. Soc. , vol.88 , pp. 3888-3890
    • Wall, M.E.1
  • 17
    • 4944264246 scopus 로고    scopus 로고
    • Molecules of interest-camptothecin, over four decades of surprising findings
    • Lorence A., and Nessler C.L. Molecules of interest-camptothecin, over four decades of surprising findings. Phytochemistry 65 (2004) 2735-2749
    • (2004) Phytochemistry , vol.65 , pp. 2735-2749
    • Lorence, A.1    Nessler, C.L.2
  • 18
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang Y.H., et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260 (1985) 14873-14878
    • (1985) J. Biol. Chem. , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1
  • 19
    • 0031429906 scopus 로고    scopus 로고
    • Fossil record and ecology of nyssa (cornaceae)
    • Eyde R.H. Fossil record and ecology of nyssa (cornaceae). Bot. Rev. 63 (1997) 97-123
    • (1997) Bot. Rev. , vol.63 , pp. 97-123
    • Eyde, R.H.1
  • 20
    • 0021749639 scopus 로고
    • Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
    • Chen G.L., et al. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem. 259 (1984) 13560-13565
    • (1984) J. Biol. Chem. , vol.259 , pp. 13560-13565
    • Chen, G.L.1
  • 21
    • 0029802613 scopus 로고    scopus 로고
    • Topoisomerase II etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes
    • Burden D.A., et al. Topoisomerase II etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J. Biol. Chem. 271 (1996) 29238-29244
    • (1996) J. Biol. Chem. , vol.271 , pp. 29238-29244
    • Burden, D.A.1
  • 22
    • 4043121827 scopus 로고    scopus 로고
    • Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives
    • Gordaliza M., et al. Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. Toxicon 44 (2004) 441-459
    • (2004) Toxicon , vol.44 , pp. 441-459
    • Gordaliza, M.1
  • 23
    • 0034125717 scopus 로고    scopus 로고
    • Timing the eastern Asian-Eastern North American floristic disjunction: molecular clock corroborates paleontological estimates
    • Xiang Q.Y., et al. Timing the eastern Asian-Eastern North American floristic disjunction: molecular clock corroborates paleontological estimates. Mol. Phylogenet. Evol. 15 (2000) 462-472
    • (2000) Mol. Phylogenet. Evol. , vol.15 , pp. 462-472
    • Xiang, Q.Y.1
  • 24
    • 43549115911 scopus 로고    scopus 로고
    • Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants
    • Facchini P.J., and De Luca V. Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J. 54 (2008) 763-784
    • (2008) Plant J. , vol.54 , pp. 763-784
    • Facchini, P.J.1    De Luca, V.2
  • 25
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan M.A., and Wilson L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer 4 (2004) 253-265
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 26
    • 0025070774 scopus 로고
    • Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
    • Rinerhart K.L., et al. Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem. 55 (1990) 4512-4515
    • (1990) J. Org. Chem. , vol.55 , pp. 4512-4515
    • Rinerhart, K.L.1
  • 27
    • 0024995421 scopus 로고
    • Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
    • Wright A.E., et al. Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata. J. Org. Chem. 55 (1990) 4508-4512
    • (1990) J. Org. Chem. , vol.55 , pp. 4508-4512
    • Wright, A.E.1
  • 28
    • 38449101447 scopus 로고    scopus 로고
    • The evolution of human reproduction: a primatological perspective
    • Martin R.D. The evolution of human reproduction: a primatological perspective. Am. J. Phys. Anthropol. Suppl. 45 (2007) 59-84
    • (2007) Am. J. Phys. Anthropol. Suppl. , vol.45 , pp. 59-84
    • Martin, R.D.1
  • 29
    • 0034619822 scopus 로고    scopus 로고
    • Mitochondrial genome variation and the origin of modern humans
    • Ingman M., et al. Mitochondrial genome variation and the origin of modern humans. Nature 408 (2000) 708-713
    • (2000) Nature , vol.408 , pp. 708-713
    • Ingman, M.1
  • 30
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P.C. The clonal evolution of tumor cell populations. Science 194 (1976) 23-28
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 31
    • 24944468183 scopus 로고    scopus 로고
    • Evolutionary biology of cancer
    • Crespi B., and Summers K. Evolutionary biology of cancer. Trends Ecol. Evol. 20 (2005) 545-552
    • (2005) Trends Ecol. Evol. , vol.20 , pp. 545-552
    • Crespi, B.1    Summers, K.2
  • 32
    • 0141465053 scopus 로고    scopus 로고
    • Genomic instability-the engine of tumorigenesis?
    • Sieber O.M., et al. Genomic instability-the engine of tumorigenesis?. Nat Rev. Cancer 3 (2003) 701-708
    • (2003) Nat Rev. Cancer , vol.3 , pp. 701-708
    • Sieber, O.M.1
  • 33
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 (2004) 789-799
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 34
    • 1542619851 scopus 로고    scopus 로고
    • Dynamics of cancer progression
    • Michor F., et al. Dynamics of cancer progression. Nat. Rev. Cancer 4 (2004) 197-205
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 197-205
    • Michor, F.1
  • 35
    • 33845243362 scopus 로고    scopus 로고
    • Cancer as an evolutionary and ecological process
    • Merlo L.M.F., et al. Cancer as an evolutionary and ecological process. Nat. Rev. Cancer 6 (2006) 924-935
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 924-935
    • Merlo, L.M.F.1
  • 36
    • 45549102966 scopus 로고    scopus 로고
    • Cancers exhibit a mutator phenotype: clinical implications
    • Loeb L.A., et al. Cancers exhibit a mutator phenotype: clinical implications. Cancer Res. 68 (2008) 3551-3557
    • (2008) Cancer Res. , vol.68 , pp. 3551-3557
    • Loeb, L.A.1
  • 37
    • 43649107543 scopus 로고    scopus 로고
    • Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression
    • Hays L.E., et al. Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression. Br. J. Cancer 98 (2008) 1653-1661
    • (2008) Br. J. Cancer , vol.98 , pp. 1653-1661
    • Hays, L.E.1
  • 38
    • 44349143334 scopus 로고    scopus 로고
    • Heavy ion carcinogenesis and human space exploration
    • Durante M., and Cucinotta F.A. Heavy ion carcinogenesis and human space exploration. Nat. Rev. Cancer 8 (2008) 465-472
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 465-472
    • Durante, M.1    Cucinotta, F.A.2
  • 39
    • 33645396945 scopus 로고    scopus 로고
    • Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    • Maley C.C., et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat. Genet. 38 (2006) 468-473
    • (2006) Nat. Genet. , vol.38 , pp. 468-473
    • Maley, C.C.1
  • 40
    • 0033592960 scopus 로고    scopus 로고
    • The onset and extent of genomic instability in sporadic colorectal tumor progression
    • Stoler D.L., et al. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 15121-15126
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 15121-15126
    • Stoler, D.L.1
  • 41
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood L.D., et al. The genomic landscapes of human breast and colorectal cancers. Science 318 (2007) 1108-1113
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 42
    • 33947101019 scopus 로고    scopus 로고
    • Patterns of somatic mutation in human cancer genomes
    • Greenman C., et al. Patterns of somatic mutation in human cancer genomes. Nature 446 (2007) 153-158
    • (2007) Nature , vol.446 , pp. 153-158
    • Greenman, C.1
  • 43
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
    • Cancer Genome Atlas Research Network1
  • 44
    • 44349191457 scopus 로고    scopus 로고
    • Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
    • Campbell P.J., et al. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat. Genet. 40 (2008) 722-729
    • (2008) Nat. Genet. , vol.40 , pp. 722-729
    • Campbell, P.J.1
  • 45
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • Knudson A.G. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer 1 (2001) 157-162
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 157-162
    • Knudson, A.G.1
  • 46
    • 85015066476 scopus 로고    scopus 로고
    • DNA damage and repair
    • Friedberg E.C. DNA damage and repair. Nature 421 (2003) 436-440
    • (2003) Nature , vol.421 , pp. 436-440
    • Friedberg, E.C.1
  • 47
    • 45749137235 scopus 로고    scopus 로고
    • Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
    • McMurray H.R., et al. Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature 453 (2008) 1112-1116
    • (2008) Nature , vol.453 , pp. 1112-1116
    • McMurray, H.R.1
  • 48
    • 33645526114 scopus 로고    scopus 로고
    • Oncogene-induced senescence: putting the brakes on tumor development
    • Braig M., and Schmitt C.A. Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res. 66 (2006) 2881-2884
    • (2006) Cancer Res. , vol.66 , pp. 2881-2884
    • Braig, M.1    Schmitt, C.A.2
  • 50
    • 34347222211 scopus 로고    scopus 로고
    • The neoselectionist theory of genome evolution
    • Bernardi G. The neoselectionist theory of genome evolution. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 8385-8390
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 8385-8390
    • Bernardi, G.1
  • 51
    • 34447564992 scopus 로고    scopus 로고
    • Mutation rate variation in multicellular eukaryotes: causes and consequences
    • Baer C.F., et al. Mutation rate variation in multicellular eukaryotes: causes and consequences. Nat. Rev. Genet. 8 (2007) 619-631
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 619-631
    • Baer, C.F.1
  • 52
    • 34547616501 scopus 로고    scopus 로고
    • The new mutation theory of phenotypic evolution
    • Nei M. The new mutation theory of phenotypic evolution. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 12235-12242
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 12235-12242
    • Nei, M.1
  • 53
    • 27944474033 scopus 로고    scopus 로고
    • Selectionism and neutralism in molecular evolution
    • Nei M. Selectionism and neutralism in molecular evolution. Mol. Biol. Evol. 22 (2005) 2318-2342
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 2318-2342
    • Nei, M.1
  • 54
    • 0014421064 scopus 로고
    • Evolution rate at the molecular level
    • Kimura M. Evolution rate at the molecular level. Nature 217 (1968) 624-626
    • (1968) Nature , vol.217 , pp. 624-626
    • Kimura, M.1
  • 55
    • 0015722319 scopus 로고
    • Slightly deleterious mutant substitutions in evolution
    • Ohta T. Slightly deleterious mutant substitutions in evolution. Nature 246 (1973) 96-98
    • (1973) Nature , vol.246 , pp. 96-98
    • Ohta, T.1
  • 56
    • 39449085063 scopus 로고    scopus 로고
    • DNA-damage repair; the good, the bad, and the ugly
    • Hakem R. DNA-damage repair; the good, the bad, and the ugly. EMBO J. 27 (2008) 589-605
    • (2008) EMBO J. , vol.27 , pp. 589-605
    • Hakem, R.1
  • 57
    • 33845627082 scopus 로고    scopus 로고
    • Cellular responses to DNA damage: one signal, multiple choices
    • Su T.T. Cellular responses to DNA damage: one signal, multiple choices. Annu. Rev. Genet. 40 (2006) 187-208
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 187-208
    • Su, T.T.1
  • 58
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: cellular senescence as a DNA-damage response
    • d'Adda F.F. Living on a break: cellular senescence as a DNA-damage response. Nat. Rev. Cancer 8 (2008) 512-522
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 512-522
    • d'Adda, F.F.1
  • 59
  • 61
    • 33644846857 scopus 로고    scopus 로고
    • Small molecules: the missing link in the central dogma
    • Schreiber S.L. Small molecules: the missing link in the central dogma. Nat. Chem. Biol. 1 (2005) 64-66
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 64-66
    • Schreiber, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.