Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid

Journal of Nutritional Biochemistry

Volumn 20, Issue 12, 2009, Pages 956-964

  Platt, Ilana D ^a   El Sohemy, Ahmed ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adipocyte; C EBP ; Conjugated linoleic acid; Mesenchymal stem cell; Osteoblast; Wnt10b

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CONJUGATED LINOLEIC ACID; FATTY ACID BINDING PROTEIN 4; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR RUNX2; WNT PROTEIN; WNT10B PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ADULT; ARTICLE; CALCIFICATION; CELL DIFFERENTIATION; CIS ISOMER; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MESENCHYMAL STEM CELL; NORMAL HUMAN; OSTEOBLAST; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ADIPOCYTES; CELL DIFFERENTIATION; FEMALE; HUMANS; LINOLEIC ACIDS, CONJUGATED; MESENCHYMAL STEM CELLS; OSTEOBLASTS; STEREOISOMERISM; YOUNG ADULT;

EID: 71649093576     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.08.008     Document Type: Article

References (73)

1. Rosen C.J., and Bouxsein M.L. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2 1 (2006) 35-43
2. Meunier P., et al. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 80 (1971) 147-154
3. Robey P.G., and Bianco P. Cellular mechanisms of age-related bone loss. In: Bilezikian J.P., Glowacki J., and Rosen C.J. (Eds). The aging skeleton (1999), Academic, San Diego, Calif 642
4. Chen J.L., et al. Osteoblast precursor cells are found in CD34+ cells from human bone marrow. Stem Cells 15 5 (1997) 368-377
5. Majors A.K., et al. Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res 15 4 (1997) 546-557
6. Neth P., et al. Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 24 8 (2006) 1892-1903
7. Brownbill R.A., Petrosian M., and Ilich J.Z. Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women. J Am Coll Nutr 24 (2005) 177-181
8. Watkins B.A., Shen C.L., McMurty J.P., Xu H., Bain S.D., Allen K.G., et al. Dietary lipids modulate bone prostaglandin E2 production, insulin-like growth factor-1 concentration and formation rate in chicks. J Nutr 127 (1997) 1084-1091
9. Kelly O., and Cashman K.D. The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomised rats. Prostaglandins Leukot Essent Fatty Acids 71 (2004) 295-301
10. Cook M.E., Jerome D.L., and Pariza M. Broilers fed conjugated linoleic acid had enhanced bone ash. Poult Sci 76 (1997) 162
11. Li Y., Seifert M.F., Ney D.M., Grahn M., Grant A.L., Allen K.G.D., and Watkins B.A. Dietary conjugated linoleic acids alter serum IGF-1 and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. J Bone Miner Res 14 (1999) 1153-1162
12. Kelly O., Cusack S., Jewell C., and Cashman K.D. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. Br J Nutr 90 (2003) 743-750
13. Platt I., Rao L.G., and El-Sohemy A. Isomer-specific effects of conjugated linoleic acid on mineralized bone nodule formation from human osteoblast-like cells. Exp Biol Med (Maywood) 232 2 (2007) 246-252
14. Hargrave K.M., et al. Influence of dietary conjugated linoleic acid and fat source on body fat and apoptosis in mice. Obes Res 12 9 (2004) 1435-1444
15. Evans M., et al. Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35 8 (2000) 899-910
16. Blankson H., et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130 12 (2000) 2943-2948
17. Gaullier J.M., et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135 4 (2005) 778-784
18. Brown J.M., et al. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J Biol Chem 279 25 (2004) 26735-26747
19. Ostrowska E., Suster D., Muralitharan M., Cross R.F., Leury B.J., Bauman D.E., and Dunshea F.R. Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy x-ray absorptiometry. Br J Nutr 89 (2003) 219-229
20. Kepler C.R., Hirons K.P., McNeill J.J., and Tove S.B. Intermediates and products of biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens. J Biol Chem 241 (1966) 1350-1354
21. Pariza M.W., Park Y., and Cook M.E. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40 4 (2001) 283-298
22. Pariza M.W., Park Y., and Cook M.E. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc Soc Exp Biol Med 223 1 (2000) 8-13
23. Weiler H., Austin S., Fitzpatrick-Wong S., Nitschmann E., Bankovic-Calic N., Mollard R., Aukema H., and Ogborn M. Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats. Am J Clin Nutr 79 (2004) 1186S-1189S
24. Burr L.L., Taylor C.G., and Weiler H.A. Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker rats. Exp Biol Med (Maywood) 231 10 (2006) 1602-1609
25. Watkins B.A., Li Y., Romsos D.R., and Seifert M.F. CLA and bone modeling in rats. In: Sebedio J.-L., Christie W.W., and Adolf R. (Eds). Advances in conjugated linoleic acid research (2003), AOCS Press, Champaign 218-250
26. Watkins B.A., Li Y., Lippman H.E., and Feng S. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism. Prostaglandins Leukot Essent Fatty Acids 68 (2003) 387-398
27. Doyle L., et al. Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men. Eur J Clin Nutr 2005 (2005) 432-440
28. Kreider R.B., et al. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 16 (2002) 325-334
29. Cusack S., Jewell C., and Cashman K.D. The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cells. Prostaglandins Leukot Essent Fatty Acids 72 (2005) 29-39
30. Park Y., Albright K.J., Liu W., Storkson J.M., Cook M.E., and Pariza M.W. Effect of conjugated linoleic acid on body composition in mice. Lipids 32 (1997) 853-858
31. DeLany J.P., et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276 4 Pt 2 (1999) R1172-R1179
32. Evans M., et al. transcis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. J Nutr 132 3 (2002) 450-455
33. Evans M., et al. transcis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids 36 11 (2001) 1223-1232
34. Park Y., et al. Evidence that the transcis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34 3 (1999) 235-241
35. Brown J.M., et al. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res 44 7 (2003) 1287-1300
36. West D.B., et al. Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr 130 10 (2000) 2471-2477
37. Tsuboyama-Kasaoka N., et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49 9 (2000) 1534-1542
38. LaRosa P.C., et al. transcis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. Physiol Genomics 27 3 (2006) 282-294
39. Granlund L., et al. transcis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 44 8 (2003) 1441-1452
40. Kang K., et al. transcis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem Biophys Res Commun 303 3 (2003) 795-799
41. Rosen E.D., and Spiegelman B.M. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 276 41 (2001) 37731-37734
42. Kubota N., et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 4 4 (1999) 597-609
43. Rosen E.D., et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4 4 (1999) 611-617
44. Nuttall M.E., and Gimble J.M. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4 3 (2004) 290-294
45. Rosen E.D., et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 16 1 (2002) 22-26
46. Bernlohr D.A., et al. Intracellular lipid-binding proteins and their genes. Annu Rev Nutr 17 (1997) 277-303
47. Reese-Wagoner A., Thompson J., and Banaszak L. Structural properties of the adipocyte lipid binding protein. Biochim Biophys Acta 1441 2-3 (1999) 106-116
48. Bernlohr D.A., and Simpson M.A. Adipose tissue and lipid metabolism. In: Vance D.E., and Vance J. (Eds). Biochemistry of Lipids (1996), Elsevier, Amsterdam 257-281
49. Ducy P., et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 5 (1997) 747-754
50. Jeon M.J., et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. J Biol Chem 278 26 (2003) 23270-23277
51. Kang S., et al. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem 282 19 (2007) 14515-14524
52. Reya T., et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13 1 (2000) 15-24
53. Bennett C.N., et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 102 9 (2005) 3324-3329
54. Ross S.E., et al. Inhibition of adipogenesis by Wnt signaling. Science 289 5481 (2000) 950-953
55. Rawadi G., et al. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 18 10 (2003) 1842-1853
56. McBeath R., et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6 4 (2004) 483-495
57. MacDougald O.A., and Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 64 (1995) 345-373
58. Mosley E.E., et al. cis-9, trans-11 conjugated linoleic acid is synthesized from vaccenic acid in lactating women. J Nutr 136 9 (2006) 2297-2301
59. Ohta A., et al. Rapid analysis of fatty acids in plasma lipids. Lipids 25 11 (1990) 742-747
60. Evans M., Brown J., and McIntosh M. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J Nutr Biochem 13 9 (2002) 508
61. Bennett C.N., et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem 277 34 (2002) 30998-31004
62. Longo K.A., et al. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277 41 (2002) 38239-38244
63. Moldes M., et al. Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem J 376 Pt 3 (2003) 607-613
64. Moon H.S., et al. Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: attenuation of lipid accumulation and reduction of apoptosis. Arch Biochem Biophys 456 1 (2006) 19-29
65. Brandebourg T.D., and Hu C.Y. Isomer-specific regulation of differentiating pig preadipocytes by conjugated linoleic acids. J Anim Sci 83 9 (2005) 2096-2105
66. Aubin J.E., et al. Osteoblast and chondroblast differentiation. Bone 17 2 Suppl (1995) 77S-83S
67. Ahn I.S., et al. Isomer-specific effect of conjugated linoleic acid on inflammatory adipokines associated with fat accumulation in 3T3-L1 adipocytes. J Med Food 9 3 (2006) 307-312
68. Ding S.T., McNeel R.L., and Mersmann H.J. Modulation of adipocyte determination and differentiation-dependent factor 1 by selected polyunsaturated fatty acids. In Vitro Cell Dev Biol Anim 38 6 (2002) 352-357
69. Amri E.Z., et al. Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression. J Lipid Res 32 9 (1991) 1449-1456
70. Distel R.J., Robinson G.S., and Spiegelman B.M. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J Biol Chem 267 9 (1992) 5937-5941
71. Granlund L., Pedersen J.I., and Nebb H.I. Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment. Biochim Biophys Acta 1687 1-3 (2005) 11-22
72. Christy R.J., et al. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A 88 6 (1991) 2593-2597
73. Park Y., et al. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34 3 (1999) 243-248